ENSG00000120526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239690 ENSG00000120526 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDCD1 protein_coding protein_coding 13.00454 2.616165 20.91512 0.2122501 0.9599648 2.994207 1.30297180 0.3679685 2.2677900 0.1855776 0.2893239 2.5912967 0.09188333 0.13403333 0.108100000 -0.02593333 1.00000000 0.03754966 FALSE TRUE
ENST00000427660 ENSG00000120526 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDCD1 protein_coding protein_coding 13.00454 2.616165 20.91512 0.2122501 0.9599648 2.994207 4.49650826 1.2800216 5.5257733 0.3024735 0.3138361 2.1013897 0.39387500 0.47763333 0.264933333 -0.21270000 0.03754966 0.03754966 FALSE TRUE
ENST00000519607 ENSG00000120526 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDCD1 protein_coding nonsense_mediated_decay 13.00454 2.616165 20.91512 0.2122501 0.9599648 2.994207 0.09354223 0.1868439 0.1087757 0.1868439 0.1087757 -0.7288126 0.02575833 0.06156667 0.004766667 -0.05680000 0.70696800 0.03754966 FALSE TRUE
MSTRG.32001.1 ENSG00000120526 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDCD1 protein_coding   13.00454 2.616165 20.91512 0.2122501 0.9599648 2.994207 6.79493898 0.6657996 12.1962931 0.3399645 0.4997713 4.1748858 0.44572500 0.27766667 0.583733333 0.30606667 0.51510391 0.03754966 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120526 E001 0.5891098 0.0181695690 7.060181e-01 0.8042585085 8 109140166 109140208 43 - 0.186 0.000 -10.997
ENSG00000120526 E002 0.6234634 0.0174954682 6.973586e-03 0.0211542445 8 109210457 109210535 79 - 0.054 0.528 4.149
ENSG00000120526 E003 0.1482932 0.0411597534 6.200748e-02   8 109240919 109240941 23 - 0.000 0.253 13.849
ENSG00000120526 E004 0.8147197 0.0152863327 2.045007e-02 0.0524377337 8 109240942 109241020 79 - 0.103 0.528 3.150
ENSG00000120526 E005 55.8924829 0.0111784244 9.277074e-02 0.1794516713 8 109241021 109242674 1654 - 1.610 1.737 0.433
ENSG00000120526 E006 81.1537532 0.0004406294 1.417184e-05 0.0000908898 8 109242675 109243150 476 - 1.755 1.960 0.691
ENSG00000120526 E007 74.9287816 0.0004300572 1.540633e-02 0.0414138510 8 109243151 109243301 151 - 1.738 1.864 0.422
ENSG00000120526 E008 2.9163012 0.0051405071 8.774542e-01 0.9252737897 8 109244350 109245321 972 - 0.497 0.528 0.152
ENSG00000120526 E009 82.8580909 0.0003553084 9.693082e-03 0.0280055707 8 109245322 109245441 120 - 1.778 1.904 0.426
ENSG00000120526 E010 60.5733125 0.0004155003 8.636175e-01 0.9160474442 8 109245442 109245481 40 - 1.666 1.679 0.044
ENSG00000120526 E011 0.1515154 0.0431918632 1.000000e+00   8 109251259 109252177 919 - 0.055 0.000 -8.995
ENSG00000120526 E012 0.0000000       8 109253879 109253946 68 -      
ENSG00000120526 E013 81.1624422 0.0003975373 8.248216e-01 0.8896395540 8 109271005 109271130 126 - 1.789 1.803 0.047
ENSG00000120526 E014 0.7834997 0.1791402063 7.135018e-01 0.8099928800 8 109271131 109271930 800 - 0.187 0.254 0.565
ENSG00000120526 E015 60.1943818 0.0004026583 4.377157e-01 0.5796205109 8 109275352 109275414 63 - 1.658 1.707 0.164
ENSG00000120526 E016 75.6884078 0.0005590385 7.082204e-01 0.8059264139 8 109275415 109275496 82 - 1.768 1.751 -0.056
ENSG00000120526 E017 124.5493051 0.0004420169 1.147338e-01 0.2124438626 8 109280968 109281172 205 - 1.989 1.925 -0.214
ENSG00000120526 E018 89.6238285 0.0005338311 4.854252e-01 0.6233027257 8 109289751 109289933 183 - 1.841 1.809 -0.109
ENSG00000120526 E019 0.1451727 0.0427998415 1.000000e+00   8 109289934 109293343 3410 - 0.054 0.000 -8.994
ENSG00000120526 E020 91.3197156 0.0005449137 3.998255e-01 0.5435453902 8 109293344 109293524 181 - 1.848 1.809 -0.134
ENSG00000120526 E021 98.0083417 0.0003014198 4.345373e-04 0.0019074744 8 109296384 109296569 186 - 1.898 1.720 -0.601
ENSG00000120526 E022 0.0000000       8 109296570 109296731 162 -      
ENSG00000120526 E023 0.1451727 0.0427998415 1.000000e+00   8 109313797 109313888 92 - 0.054 0.000 -8.994
ENSG00000120526 E024 72.3238715 0.0003720743 5.158574e-04 0.0022187632 8 109322309 109322463 155 - 1.773 1.564 -0.710
ENSG00000120526 E025 0.0000000       8 109329805 109329934 130 -      
ENSG00000120526 E026 56.5733005 0.0004230030 1.248627e-03 0.0048056522 8 109333893 109334121 229 - 1.668 1.446 -0.760