ENSG00000120509

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239666 ENSG00000120509 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD11 protein_coding protein_coding 65.68344 105.4835 44.99385 10.55075 1.16596 -1.229033 57.547709 94.880312 37.201669 10.0635198 0.36335296 -1.3505057 0.86825833 0.8982333 0.82756667 -0.07066667 0.005406313 1.724768e-05 FALSE  
ENST00000374454 ENSG00000120509 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD11 protein_coding protein_coding 65.68344 105.4835 44.99385 10.55075 1.16596 -1.229033 3.250126 4.989889 3.734867 0.0820252 0.05236704 -0.4169814 0.05050833 0.0482000 0.08316667 0.03496667 0.001527621 1.724768e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120509 E001 1.435150 0.1408242542 2.471708e-01 3.825946e-01 X 70223517 70223535 19 - 0.498 0.258 -1.406
ENSG00000120509 E002 2.863769 0.0094532380 7.952157e-02 1.587791e-01 X 70223536 70223670 135 - 0.724 0.443 -1.276
ENSG00000120509 E003 2.039033 0.1230797619 1.791670e-01 3.001049e-01 X 70280763 70280910 148 - 0.627 0.342 -1.435
ENSG00000120509 E004 3.454980 0.0054995877 4.280439e-02 9.618955e-02 X 70281118 70282209 1092 - 0.805 0.501 -1.310
ENSG00000120509 E005 2.058629 0.1400357315 9.296749e-03 2.702492e-02 X 70282210 70282212 3 - 0.766 0.253 -2.610
ENSG00000120509 E006 4.272708 0.0038685984 1.794394e-02 4.701639e-02 X 70282213 70282275 63 - 0.902 0.575 -1.343
ENSG00000120509 E007 31.949375 0.0006129068 9.348297e-22 7.234505e-20 X 70284164 70286594 2431 - 1.813 1.234 -1.986
ENSG00000120509 E008 33.115859 0.0008268025 9.170843e-02 1.778035e-01 X 70286595 70286604 10 - 1.373 1.501 0.443
ENSG00000120509 E009 54.136750 0.0004395174 2.805374e-01 4.203933e-01 X 70286605 70286611 7 - 1.627 1.694 0.226
ENSG00000120509 E010 329.266171 0.0001911916 1.578724e-10 2.692515e-09 X 70286612 70286768 157 - 2.327 2.486 0.530
ENSG00000120509 E011 500.959306 0.0028122126 1.466254e-04 7.325739e-04 X 70286769 70286891 123 - 2.539 2.655 0.386
ENSG00000120509 E012 486.943114 0.0011322910 2.839088e-02 6.879899e-02 X 70286892 70286985 94 - 2.577 2.632 0.181
ENSG00000120509 E013 661.248214 0.0001400026 3.560968e-02 8.282665e-02 X 70286986 70287116 131 - 2.725 2.764 0.129
ENSG00000120509 E014 479.804439 0.0001758254 2.912415e-02 7.024345e-02 X 70287276 70287336 61 - 2.579 2.626 0.156
ENSG00000120509 E015 519.082955 0.0002031530 1.739268e-01 2.932895e-01 X 70287732 70287830 99 - 2.627 2.657 0.101
ENSG00000120509 E016 413.113870 0.0001572274 7.178673e-01 8.131326e-01 X 70288117 70288173 57 - 2.553 2.551 -0.004
ENSG00000120509 E017 567.109860 0.0001398806 2.199497e-04 1.049354e-03 X 70288430 70288511 82 - 2.729 2.674 -0.184
ENSG00000120509 E018 314.977790 0.0001509565 3.473579e-06 2.564533e-05 X 70288512 70288513 2 - 2.504 2.409 -0.319
ENSG00000120509 E019 527.426110 0.0001885734 4.356823e-06 3.143134e-05 X 70289255 70289354 100 - 2.711 2.637 -0.246
ENSG00000120509 E020 5.568864 0.0145957395 3.169452e-01 4.597645e-01 X 70289355 70289521 167 - 0.872 0.740 -0.521
ENSG00000120509 E021 34.265443 0.0007177534 4.663203e-02 1.031779e-01 X 70289522 70289593 72 - 1.575 1.453 -0.418
ENSG00000120509 E022 5.180501 0.1032904602 1.431505e-01 2.523136e-01 X 70289594 70289854 261 - 0.930 0.642 -1.152
ENSG00000120509 E023 2.742379 0.1132395974 2.797294e-01 4.194944e-01 X 70289855 70289859 5 - 0.317 0.573 1.353
ENSG00000120509 E024 331.821293 0.0012529297 3.667424e-03 1.220308e-02 X 70289860 70289945 86 - 2.510 2.436 -0.248
ENSG00000120509 E025 5.072675 0.0033716722 6.765534e-01 7.815020e-01 X 70290404 70290514 111 - 0.766 0.711 -0.226