ENSG00000120334

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345664 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding protein_coding 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 0.7326326 1.2179029 0.7890775 0.22796750 0.49162423 -0.6197892 0.11261667 0.32356667 0.05843333 -0.265133333 1.592395e-01 4.832342e-06 FALSE TRUE
ENST00000356198 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding protein_coding 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 1.0754917 0.5201042 1.7345038 0.07221660 0.36030384 1.7184688 0.14452500 0.13963333 0.11913333 -0.020500000 8.048857e-01 4.832342e-06 FALSE TRUE
ENST00000367710 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding protein_coding 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 1.7021756 0.0000000 2.3314666 0.00000000 1.22537078 7.8712686 0.16617083 0.00000000 0.15423333 0.154233333 3.213436e-01 4.832342e-06 FALSE TRUE
ENST00000460816 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding processed_transcript 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 0.3819676 0.0000000 0.8005083 0.00000000 0.02215921 6.3407551 0.03418333 0.00000000 0.05603333 0.056033333 4.832342e-06 4.832342e-06 FALSE TRUE
ENST00000495275 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding processed_transcript 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 0.8385795 0.3695554 1.4936521 0.07830338 0.15021201 1.9860883 0.12783750 0.10513333 0.10326667 -0.001866667 9.494290e-01 4.832342e-06 FALSE FALSE
ENST00000682279 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding protein_coding 8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 2.9313847 1.3799437 5.2114489 0.41289576 0.51349929 1.9094238 0.32245833 0.35493333 0.36566667 0.010733333 1.000000e+00 4.832342e-06 FALSE TRUE
MSTRG.2614.6 ENSG00000120334 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPL protein_coding   8.720963 3.736987 14.39858 0.5609974 0.6917792 1.943126 0.5844099 0.1298359 1.7686531 0.12983593 0.48917508 3.6689781 0.04953750 0.04243333 0.12573333 0.083300000 2.764887e-01 4.832342e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120334 E001 41.1691916 0.0005886149 4.516421e-03 1.459061e-02 1 173799550 173799849 300 - 1.538 1.690 0.518
ENSG00000120334 E002 94.2202695 0.0003141686 6.529475e-06 4.527946e-05 1 173799850 173800327 478 - 1.892 2.048 0.523
ENSG00000120334 E003 46.7822016 0.0023265172 1.226037e-01 2.236647e-01 1 173800328 173800411 84 - 1.622 1.703 0.278
ENSG00000120334 E004 56.0611599 0.0009103477 6.842401e-03 2.081629e-02 1 173800412 173800519 108 - 1.681 1.807 0.426
ENSG00000120334 E005 130.6324338 0.0003414951 3.046962e-01 4.467266e-01 1 173802963 173803445 483 - 2.073 2.096 0.077
ENSG00000120334 E006 39.4097120 0.0006496467 5.993498e-01 7.207652e-01 1 173803446 173803505 60 - 1.561 1.583 0.075
ENSG00000120334 E007 4.1372935 0.0037833773 7.836043e-01 8.611425e-01 1 173806439 173806458 20 - 0.693 0.642 -0.215
ENSG00000120334 E008 7.1257291 0.0023759649 3.855554e-01 5.297460e-01 1 173806459 173806576 118 - 0.910 0.784 -0.486
ENSG00000120334 E009 39.9219419 0.0028052686 6.012443e-01 7.223738e-01 1 173807267 173807310 44 - 1.568 1.589 0.072
ENSG00000120334 E010 56.2034578 0.0006350548 2.979457e-01 4.393251e-01 1 173807311 173807518 208 - 1.739 1.675 -0.216
ENSG00000120334 E011 0.1515154 0.0438175103 1.000000e+00   1 173811120 173811131 12 - 0.075 0.001 -7.237
ENSG00000120334 E012 61.7328954 0.0004715697 1.045340e-01 1.974127e-01 1 173811132 173811306 175 - 1.785 1.695 -0.304
ENSG00000120334 E013 47.8973771 0.0409220704 4.423566e-01 5.839777e-01 1 173821809 173823925 2117 - 1.679 1.552 -0.431
ENSG00000120334 E014 59.5895087 0.0005906870 3.992930e-02 9.090693e-02 1 173823926 173824019 94 - 1.774 1.659 -0.390
ENSG00000120334 E015 3.9395651 0.0272489874 2.368923e-01 3.705784e-01 1 173824020 173824137 118 - 0.602 0.784 0.762
ENSG00000120334 E016 21.7761406 0.0053806000 1.924658e-04 9.316314e-04 1 173824138 173824211 74 - 1.395 1.002 -1.395
ENSG00000120334 E017 63.7722236 0.0084411326 2.884215e-03 9.922926e-03 1 173824212 173824561 350 - 1.822 1.611 -0.715
ENSG00000120334 E018 26.8997866 0.0083522560 4.282626e-03 1.393464e-02 1 173824562 173824883 322 - 1.469 1.195 -0.958