ENSG00000120265

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367378 ENSG00000120265 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMT1 protein_coding protein_coding 120.2009 75.55925 170.8027 16.52912 3.822173 1.176544 22.01811 16.21550 24.82810 4.554150 0.6992028 0.6142918 0.2022542 0.2092333 0.1454333 -0.0638 0.01351783 0.01351783 FALSE  
ENST00000367384 ENSG00000120265 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMT1 protein_coding protein_coding 120.2009 75.55925 170.8027 16.52912 3.822173 1.176544 18.34939 10.02935 27.83385 2.473577 0.3439467 1.4716926 0.1456542 0.1315000 0.1631000 0.0316 0.30311837 0.01351783 FALSE  
ENST00000464889 ENSG00000120265 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMT1 protein_coding protein_coding 120.2009 75.55925 170.8027 16.52912 3.822173 1.176544 77.44091 47.42846 115.03867 9.343245 3.2565858 1.2781152 0.6303292 0.6342000 0.6734000 0.0392 0.58632694 0.01351783 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120265 E001 0.4460135 3.606830e-02 2.534805e-01 3.900098e-01 6 149749443 149749443 1 + 0.234 0.000 -10.591
ENSG00000120265 E002 1.8153862 3.467938e-01 9.062040e-01 9.443733e-01 6 149749444 149749694 251 + 0.464 0.379 -0.453
ENSG00000120265 E003 6.3871510 7.495986e-03 3.612819e-01 5.056798e-01 6 149749695 149749726 32 + 0.897 0.771 -0.490
ENSG00000120265 E004 26.5181517 6.902479e-03 1.812236e-01 3.027643e-01 6 149749727 149749740 14 + 1.474 1.358 -0.400
ENSG00000120265 E005 321.3724066 3.538617e-03 5.507833e-02 1.181359e-01 6 149749741 149749815 75 + 2.532 2.447 -0.283
ENSG00000120265 E006 843.5989443 3.367878e-04 4.956066e-04 2.143274e-03 6 149749816 149749956 141 + 2.943 2.889 -0.180
ENSG00000120265 E007 1.4132927 1.057895e-02 5.661554e-01 6.931711e-01 6 149750044 149750265 222 + 0.340 0.444 0.582
ENSG00000120265 E008 0.5514428 2.176816e-02 2.333908e-02 5.845708e-02 6 149765691 149765753 63 + 0.000 0.369 13.036
ENSG00000120265 E009 938.7844116 1.280262e-04 3.674810e-03 1.222465e-02 6 149771162 149771266 105 + 2.984 2.948 -0.120
ENSG00000120265 E010 0.1472490 4.608043e-02 1.000000e+00   6 149772014 149772047 34 + 0.093 0.000 -10.733
ENSG00000120265 E011 2.4325083 6.965728e-03 7.539877e-01 8.397356e-01 6 149772048 149772247 200 + 0.558 0.509 -0.233
ENSG00000120265 E012 1.1898584 2.000658e-01 8.451636e-01 9.036782e-01 6 149772555 149772684 130 + 0.341 0.282 -0.381
ENSG00000120265 E013 608.6670396 2.615170e-04 3.025228e-02 7.246249e-02 6 149773138 149773169 32 + 2.795 2.759 -0.122
ENSG00000120265 E014 899.4356258 1.208762e-04 4.122724e-03 1.348570e-02 6 149789954 149790058 105 + 2.965 2.929 -0.120
ENSG00000120265 E015 1216.6890852 2.280142e-04 8.335005e-02 1.648131e-01 6 149793549 149793669 121 + 3.090 3.070 -0.068
ENSG00000120265 E016 1138.9344966 9.547921e-05 4.624998e-01 6.023511e-01 6 149796415 149796500 86 + 3.051 3.060 0.030
ENSG00000120265 E017 1512.7724881 6.745651e-05 7.351640e-07 6.286658e-06 6 149802200 149802369 170 + 3.159 3.205 0.154
ENSG00000120265 E018 443.8434124 1.705597e-04 7.585209e-05 4.083881e-04 6 149802370 149802416 47 + 2.617 2.688 0.235
ENSG00000120265 E019 124.0796042 4.676323e-03 8.832444e-09 1.099685e-07 6 149802417 149802424 8 + 1.968 2.243 0.921
ENSG00000120265 E020 114.6844300 3.894800e-03 1.343928e-09 1.944575e-08 6 149802425 149802530 106 + 1.933 2.213 0.940
ENSG00000120265 E021 5.6690502 1.341412e-02 2.677754e-01 4.061167e-01 6 149810040 149810123 84 + 0.760 0.909 0.580
ENSG00000120265 E022 1800.8197573 1.053325e-04 9.911263e-01 9.985689e-01 6 149810616 149811420 805 + 3.253 3.252 -0.001