ENSG00000120159

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333916 ENSG00000120159 HEK293_OSMI2_2hA HEK293_TMG_2hB CAAP1 protein_coding protein_coding 11.873 4.551503 19.12898 0.6559804 0.7070785 2.068932 6.2040632 3.9621479 9.706407 0.7845959 0.5870874 1.290504 0.6296333 0.8570 0.50776667 -0.34923333 2.427989e-03 5.682502e-05 FALSE TRUE
ENST00000517946 ENSG00000120159 HEK293_OSMI2_2hA HEK293_TMG_2hB CAAP1 protein_coding processed_transcript 11.873 4.551503 19.12898 0.6559804 0.7070785 2.068932 0.5973229 0.0000000 1.630810 0.0000000 0.6089135 7.358264 0.0337000 0.0000 0.08323333 0.08323333 5.682502e-05 5.682502e-05 FALSE TRUE
ENST00000625311 ENSG00000120159 HEK293_OSMI2_2hA HEK293_TMG_2hB CAAP1 protein_coding protein_coding 11.873 4.551503 19.12898 0.6559804 0.7070785 2.068932 4.3586832 0.5423603 6.314143 0.1560132 0.5712686 3.517188 0.2932042 0.1334 0.33086667 0.19746667 8.804182e-02 5.682502e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120159 E001 1.178128 0.0110623745 8.590665e-03 2.526548e-02 9 26840685 26840710 26 - 0.133 0.596 3.034
ENSG00000120159 E002 165.858484 0.0026708356 7.647067e-19 4.286136e-17 9 26840711 26841735 1025 - 2.067 2.379 1.043
ENSG00000120159 E003 190.062774 0.0006191958 5.655654e-07 4.953063e-06 9 26841736 26842265 530 - 2.188 2.336 0.493
ENSG00000120159 E004 102.187613 0.0002916233 2.013236e-02 5.176109e-02 9 26842266 26842393 128 - 1.986 1.906 -0.269
ENSG00000120159 E005 177.213306 0.0002002249 1.026938e-02 2.943005e-02 9 26842394 26842647 254 - 2.218 2.155 -0.210
ENSG00000120159 E006 64.230088 0.0020529089 4.442277e-04 1.944492e-03 9 26861066 26861088 23 - 1.807 1.620 -0.634
ENSG00000120159 E007 75.160563 0.0004349310 6.112874e-03 1.890503e-02 9 26861089 26861139 51 - 1.861 1.742 -0.401
ENSG00000120159 E008 1.913433 0.0077354209 1.293830e-01 2.333179e-01 9 26866634 26866780 147 - 0.499 0.201 -1.873
ENSG00000120159 E009 2.287425 0.0117778990 8.219255e-02 1.629649e-01 9 26869926 26869977 52 - 0.546 0.201 -2.093
ENSG00000120159 E010 88.337302 0.0004504370 6.923231e-03 2.102304e-02 9 26884810 26884885 76 - 1.925 1.818 -0.361
ENSG00000120159 E011 0.894217 0.0138931037 1.521143e-01 2.645599e-01 9 26884886 26884902 17 - 0.318 0.000 -10.393
ENSG00000120159 E012 68.960218 0.0004224142 1.950278e-01 3.200187e-01 9 26886104 26886188 85 - 1.807 1.756 -0.173
ENSG00000120159 E013 93.036879 0.0004493065 2.673954e-05 1.609700e-04 9 26887313 26887513 201 - 1.963 1.790 -0.581
ENSG00000120159 E014 11.873747 0.0122065614 6.503165e-01 7.613664e-01 9 26892259 26892412 154 - 1.071 1.019 -0.189
ENSG00000120159 E015 88.148562 0.0234304944 1.302227e-01 2.344729e-01 9 26892413 26892803 391 - 1.931 1.795 -0.460