ENSG00000120158

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381750 ENSG00000120158 HEK293_OSMI2_2hA HEK293_TMG_2hB RCL1 protein_coding protein_coding 16.80322 19.67032 15.16521 2.401611 0.6972 -0.375037 9.972214 13.490288 7.474730 1.6517943 0.8929728 -0.8509680 0.5825458 0.6864000 0.4911000 -0.1953 0.008486938 0.008486938 FALSE TRUE
MSTRG.32333.1 ENSG00000120158 HEK293_OSMI2_2hA HEK293_TMG_2hB RCL1 protein_coding   16.80322 19.67032 15.16521 2.401611 0.6972 -0.375037 5.580485 4.625839 6.604518 0.6078069 0.7202462 0.5128055 0.3426500 0.2347667 0.4381667 0.2034 0.010858999 0.008486938 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120158 E001 9.7821136 0.0049545352 0.017645260 0.046371677 9 4792931 4792943 13 + 1.162 0.913 -0.912
ENSG00000120158 E002 14.9460532 0.0013575959 0.054065661 0.116366476 9 4792944 4792955 12 + 1.286 1.122 -0.580
ENSG00000120158 E003 46.1580544 0.0162990739 0.129971578 0.234130999 9 4792956 4792975 20 + 1.734 1.603 -0.447
ENSG00000120158 E004 47.5804342 0.0170043516 0.083067844 0.164356325 9 4792976 4792979 4 + 1.759 1.608 -0.513
ENSG00000120158 E005 87.7767668 0.0103705627 0.004920048 0.015707324 9 4792980 4793086 107 + 2.036 1.857 -0.603
ENSG00000120158 E006 141.9263679 0.0035831778 0.014917944 0.040302318 9 4793087 4793227 141 + 2.200 2.099 -0.337
ENSG00000120158 E007 105.3800942 0.0003097414 0.011142048 0.031507239 9 4823548 4823619 72 + 2.064 1.981 -0.280
ENSG00000120158 E008 179.9925086 0.0002346181 0.009306929 0.027048547 9 4826858 4827033 176 + 2.286 2.222 -0.212
ENSG00000120158 E009 0.1472490 0.0451695378 0.337901506   9 4827034 4827337 304 + 0.145 0.000 -11.546
ENSG00000120158 E010 132.3723852 0.0002616948 0.443692032 0.585275692 9 4833154 4833228 75 + 2.127 2.108 -0.064
ENSG00000120158 E011 171.2798903 0.0002514650 0.324959284 0.468384320 9 4834141 4834265 125 + 2.206 2.237 0.104
ENSG00000120158 E012 0.6235652 0.0204542053 0.162107617 0.277872999 9 4836726 4836764 39 + 0.341 0.103 -2.164
ENSG00000120158 E013 1.2523272 0.0101985541 0.203123891 0.330140801 9 4839518 4839693 176 + 0.476 0.255 -1.317
ENSG00000120158 E014 0.6997360 0.0166947382 0.088485514 0.172806993 9 4839769 4839776 8 + 0.000 0.315 12.112
ENSG00000120158 E015 1.5864763 0.0107595061 0.530672634 0.663229640 9 4839777 4839859 83 + 0.341 0.456 0.640
ENSG00000120158 E016 0.8147328 0.1379449926 0.995474237 1.000000000 9 4841202 4841204 3 + 0.255 0.254 -0.003
ENSG00000120158 E017 1.1113191 0.0362496007 0.560347734 0.688347073 9 4841205 4841231 27 + 0.254 0.366 0.734
ENSG00000120158 E018 161.8511092 0.0031666420 0.043879418 0.098164025 9 4841232 4841357 126 + 2.147 2.228 0.272
ENSG00000120158 E019 169.8238716 0.0021688210 0.059747097 0.126189083 9 4844525 4844681 157 + 2.177 2.245 0.228
ENSG00000120158 E020 157.2754253 0.0119223818 0.260815553 0.398396472 9 4849447 4849550 104 + 2.143 2.206 0.210
ENSG00000120158 E021 257.1406176 0.0006618554 0.007792442 0.023255478 9 4860125 4860453 329 + 2.357 2.423 0.222
ENSG00000120158 E022 216.2027029 0.0034183660 0.051569340 0.111943635 9 4860454 4860901 448 + 2.276 2.346 0.233
ENSG00000120158 E023 46.2053884 0.0004941417 0.002286070 0.008108281 9 4860902 4861075 174 + 1.547 1.717 0.578
ENSG00000120158 E024 0.1817044 0.0414881942 0.684289929   9 4875830 4875887 58 + 0.000 0.103 10.113
ENSG00000120158 E025 22.0368351 0.0008635956 0.215764843 0.345318168 9 4884488 4885917 1430 + 1.403 1.316 -0.301