ENSG00000120071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432791 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 0.8305728 0.34237421 1.2247748 0.16834755 0.21152141 1.8090677 0.05940000 0.032933333 0.07603333 0.04310000 3.985318e-01 1.47514e-13 FALSE TRUE
ENST00000572904 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 5.9955091 6.99109670 5.3987499 0.29732509 0.45074842 -0.3722857 0.46318333 0.688033333 0.33476667 -0.35326667 7.180291e-05 1.47514e-13 FALSE TRUE
ENST00000574590 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 0.9469077 0.44257731 0.6707862 0.33233049 0.04811438 0.5890375 0.06420833 0.041633333 0.04113333 -0.00050000 7.805021e-01 1.47514e-13 FALSE TRUE
ENST00000575318 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 0.8868895 1.41851389 0.9362732 0.08271473 0.47970360 -0.5941864 0.07323333 0.139933333 0.06003333 -0.07990000 5.686636e-01 1.47514e-13 FALSE TRUE
ENST00000639531 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 1.0753278 0.03603775 2.2934294 0.02286100 0.37356080 5.6448223 0.06843750 0.003533333 0.13940000 0.13586667 1.475140e-13 1.47514e-13 FALSE TRUE
ENST00000648792 ENSG00000120071 HEK293_OSMI2_2hA HEK293_TMG_2hB KANSL1 protein_coding protein_coding 13.72139 10.18361 16.36058 0.3097918 0.8893261 0.6834396 0.8520835 0.00000000 1.3447807 0.00000000 0.72332067 7.0819155 0.05620000 0.000000000 0.07803333 0.07803333 2.280388e-01 1.47514e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120071 E001 0.1482932 0.0414249194 4.107764e-01   17 46029916 46029916 1 - 0.000 0.139 10.229
ENSG00000120071 E002 0.3697384 0.0274424043 1.545206e-01 2.677827e-01 17 46029917 46029917 1 - 0.000 0.245 13.720
ENSG00000120071 E003 3.3557764 0.0047551367 8.259665e-02 1.636103e-01 17 46029918 46029955 38 - 0.471 0.773 1.334
ENSG00000120071 E004 9.1051740 0.0146859235 1.349589e-02 3.706839e-02 17 46029956 46029984 29 - 0.819 1.163 1.280
ENSG00000120071 E005 472.8880486 0.0105602837 8.375533e-10 1.259002e-08 17 46029985 46031073 1089 - 2.482 2.822 1.132
ENSG00000120071 E006 252.6674174 0.0036681950 6.766644e-07 5.827706e-06 17 46031074 46031653 580 - 2.280 2.508 0.758
ENSG00000120071 E007 56.3703113 0.0007231610 2.475559e-02 6.137452e-02 17 46031654 46031703 50 - 1.670 1.829 0.536
ENSG00000120071 E008 7.3189453 0.0022627675 5.610590e-03 1.758008e-02 17 46031704 46032046 343 - 1.032 0.744 -1.103
ENSG00000120071 E009 64.1353758 0.0052058916 9.290961e-02 1.796819e-01 17 46032047 46032116 70 - 1.733 1.878 0.489
ENSG00000120071 E010 53.9429272 0.0006301434 1.056002e-02 3.011239e-02 17 46032117 46032164 48 - 1.644 1.819 0.593
ENSG00000120071 E011 33.7045780 0.0088222590 1.859186e-01 3.086467e-01 17 46032165 46032167 3 - 1.457 1.606 0.508
ENSG00000120071 E012 34.9315448 0.0044824776 7.907673e-02 1.580358e-01 17 46032168 46032185 18 - 1.461 1.629 0.572
ENSG00000120071 E013 33.9799752 0.0006207601 1.898681e-01 3.135920e-01 17 46032186 46032219 34 - 1.474 1.603 0.442
ENSG00000120071 E014 34.6980153 0.0060300190 4.687061e-02 1.035981e-01 17 46032220 46032256 37 - 1.449 1.636 0.642
ENSG00000120071 E015 25.7657342 0.0056957030 5.748762e-02 1.223219e-01 17 46032257 46032267 11 - 1.319 1.513 0.672
ENSG00000120071 E016 29.8780319 0.0006727931 6.966755e-02 1.428126e-01 17 46032268 46032294 27 - 1.398 1.564 0.570
ENSG00000120071 E017 21.2434830 0.0008841940 1.196352e-01 2.194475e-01 17 46032295 46032299 5 - 1.256 1.422 0.577
ENSG00000120071 E018 8.3356453 0.0051711975 2.531456e-03 8.857430e-03 17 46032300 46032566 267 - 1.085 0.773 -1.180
ENSG00000120071 E019 2.9946751 0.0053036053 2.268105e-01 3.585824e-01 17 46033045 46033079 35 - 0.666 0.515 -0.674
ENSG00000120071 E020 24.3286207 0.0007984330 1.596369e-02 4.264825e-02 17 46033080 46033098 19 - 1.282 1.501 0.759
ENSG00000120071 E021 50.3418949 0.0004623977 7.721688e-02 1.550297e-01 17 46033099 46033192 94 - 1.635 1.774 0.471
ENSG00000120071 E022 47.3193731 0.0007606783 1.933679e-01 3.180083e-01 17 46033403 46033460 58 - 1.618 1.737 0.402
ENSG00000120071 E023 1.9521544 0.0069780420 2.296663e-02 5.767750e-02 17 46033461 46033469 9 - 0.610 0.245 -2.018
ENSG00000120071 E024 2.7595003 0.0060076357 4.413551e-02 9.863560e-02 17 46033470 46033512 43 - 0.691 0.401 -1.366
ENSG00000120071 E025 35.0229552 0.0040668179 1.789249e-01 2.997938e-01 17 46034161 46034168 8 - 1.478 1.617 0.475
ENSG00000120071 E026 79.3478973 0.0011951096 2.122112e-01 3.411352e-01 17 46034169 46034279 111 - 1.902 1.901 -0.002
ENSG00000120071 E027 42.0149021 0.0005383987 1.012673e-02 2.907492e-02 17 46034280 46034282 3 - 1.670 1.582 -0.301
ENSG00000120071 E028 36.9467779 0.0011492988 1.338449e-02 3.681100e-02 17 46034283 46034285 3 - 1.621 1.527 -0.322
ENSG00000120071 E029 0.6685028 0.0163770215 8.551653e-01 9.104341e-01 17 46034286 46034368 83 - 0.193 0.245 0.442
ENSG00000120071 E030 1.6305733 0.0091320969 3.267441e-01 4.701938e-01 17 46034369 46034431 63 - 0.471 0.330 -0.780
ENSG00000120071 E031 0.9609246 0.0130222646 5.528656e-01 6.820997e-01 17 46034432 46034460 29 - 0.326 0.245 -0.558
ENSG00000120071 E032 5.3314078 0.0030903106 1.048424e-04 5.443602e-04 17 46034461 46034763 303 - 0.972 0.462 -2.144
ENSG00000120071 E033 10.1996700 0.0048595717 9.475125e-04 3.779735e-03 17 46034764 46035924 1161 - 1.167 0.850 -1.172
ENSG00000120071 E034 7.8122130 0.0826864933 4.707519e-02 1.039585e-01 17 46037325 46038537 1213 - 1.056 0.751 -1.158
ENSG00000120071 E035 75.0430908 0.0003270045 1.685509e-03 6.236926e-03 17 46038538 46038635 98 - 1.912 1.836 -0.257
ENSG00000120071 E036 55.8076319 0.0004141062 6.160099e-02 1.293183e-01 17 46038636 46038686 51 - 1.769 1.733 -0.122
ENSG00000120071 E037 1.1071545 0.0114849203 8.941872e-01 9.363573e-01 17 46038687 46039026 340 - 0.326 0.330 0.026
ENSG00000120071 E038 81.6113888 0.0003489752 5.872483e-01 7.105694e-01 17 46039027 46039215 189 - 1.903 1.934 0.104
ENSG00000120071 E039 3.5773034 0.0186507476 7.779102e-03 2.322526e-02 17 46039216 46039701 486 - 0.800 0.401 -1.803
ENSG00000120071 E040 104.9440506 0.0003530801 6.137775e-01 7.324111e-01 17 46039702 46039869 168 - 2.009 2.044 0.116
ENSG00000120071 E041 44.0302941 0.0005569619 8.488429e-01 9.061700e-01 17 46039870 46039884 15 - 1.627 1.688 0.209
ENSG00000120071 E042 3.8146657 0.0080896152 5.578610e-01 6.861866e-01 17 46039885 46046121 6237 - 0.691 0.645 -0.194
ENSG00000120071 E043 0.6997360 0.0166511822 2.380746e-02 5.941813e-02 17 46049399 46050532 1134 - 0.000 0.401 14.806
ENSG00000120071 E044 76.8500891 0.0022151943 1.730506e-01 2.921553e-01 17 46050533 46050649 117 - 1.896 1.886 -0.033
ENSG00000120071 E045 59.8265929 0.0010830141 4.940117e-02 1.080967e-01 17 46050650 46050704 55 - 1.801 1.760 -0.139
ENSG00000120071 E046 107.1271402 0.0003232105 1.765122e-06 1.389343e-05 17 46066537 46066732 196 - 2.082 1.969 -0.378
ENSG00000120071 E047 84.5440815 0.0032087030 1.696669e-04 8.335812e-04 17 46067549 46067667 119 - 1.984 1.860 -0.418
ENSG00000120071 E048 65.5178049 0.0004068720 1.205437e-05 7.859797e-05 17 46082441 46082542 102 - 1.883 1.742 -0.475
ENSG00000120071 E049 0.2966881 0.0271298025 2.555715e-01   17 46088428 46088680 253 - 0.193 0.000 -13.934
ENSG00000120071 E050 0.0000000       17 46092870 46094507 1638 -      
ENSG00000120071 E051 1.9049354 0.0401568662 7.702767e-01 8.516419e-01 17 46094508 46094559 52 - 0.427 0.515 0.439
ENSG00000120071 E052 90.3113978 0.0008349827 6.112733e-03 1.890491e-02 17 46094560 46094701 142 - 1.983 1.929 -0.184
ENSG00000120071 E053 0.0000000       17 46119967 46120049 83 -      
ENSG00000120071 E054 0.0000000       17 46121324 46121338 15 -      
ENSG00000120071 E055 0.0000000       17 46148125 46148239 115 -      
ENSG00000120071 E056 0.3289534 0.0295970145 8.917521e-01   17 46152904 46152966 63 - 0.107 0.140 0.442
ENSG00000120071 E057 0.1451727 0.0430241080 5.786631e-01   17 46156774 46156895 122 - 0.107 0.000 -12.784
ENSG00000120071 E058 0.1515154 0.0429039130 5.784338e-01   17 46169531 46169605 75 - 0.107 0.000 -12.786
ENSG00000120071 E059 1.3434502 0.2996848557 4.012220e-01 5.449236e-01 17 46170277 46170854 578 - 0.429 0.252 -1.097
ENSG00000120071 E060 366.4236758 0.0004999080 2.755833e-33 5.953070e-31 17 46170855 46172116 1262 - 2.642 2.453 -0.631
ENSG00000120071 E061 39.3648118 0.0005787488 1.001323e-12 2.458178e-11 17 46172117 46172232 116 - 1.740 1.369 -1.268
ENSG00000120071 E062 1.3577340 0.0117703791 2.812169e-02 6.825492e-02 17 46192419 46192822 404 - 0.510 0.140 -2.558
ENSG00000120071 E063 11.4172121 0.0661823410 5.341355e-03 1.686085e-02 17 46192823 46193429 607 - 1.228 0.837 -1.438
ENSG00000120071 E064 0.3666179 0.0292953657 8.912509e-01 9.345334e-01 17 46193750 46193901 152 - 0.107 0.140 0.445
ENSG00000120071 E065 0.6256415 0.0175418820 4.071342e-01 5.507423e-01 17 46221186 46223670 2485 - 0.264 0.140 -1.143
ENSG00000120071 E066 24.0729009 0.0151106398 8.779289e-04 3.536938e-03 17 46223671 46223804 134 - 1.505 1.246 -0.901
ENSG00000120071 E067 4.9362098 0.0035803550 2.692369e-04 1.254547e-03 17 46224561 46224902 342 - 0.945 0.462 -2.044
ENSG00000120071 E068 4.7808398 0.0453085187 8.619703e-01 9.150226e-01 17 46225341 46225389 49 - 0.760 0.771 0.044