ENSG00000120008

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263461 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding protein_coding 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 9.9560231 2.7617910 18.6240640 0.05364312 0.45925917 2.7490520 0.39565417 0.29013333 0.565566667 0.27543333 5.096682e-16 5.096682e-16 FALSE TRUE
ENST00000497136 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding nonsense_mediated_decay 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 3.0501356 1.3194099 3.6991451 0.11893789 0.07403961 1.4803007 0.15459167 0.13783333 0.112566667 -0.02526667 4.617897e-01 5.096682e-16 TRUE TRUE
ENST00000603658 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding retained_intron 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 2.1111423 0.7746025 3.4809709 0.26020639 0.29120540 2.1535945 0.10425417 0.08346667 0.105600000 0.02213333 6.878528e-01 5.096682e-16 FALSE FALSE
ENST00000604714 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding processed_transcript 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 0.9506425 0.6598719 0.9437974 0.12196088 0.12204837 0.5097975 0.05680000 0.06870000 0.028900000 -0.03980000 2.354022e-02 5.096682e-16 FALSE FALSE
ENST00000605202 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding processed_transcript 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 0.8113678 0.0000000 1.9153153 0.00000000 0.32226571 7.5889509 0.02536250 0.00000000 0.058600000 0.05860000 6.433359e-09 5.096682e-16   FALSE
ENST00000605543 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding nonsense_mediated_decay 21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 0.7368468 1.9218233 0.0000000 0.56048981 0.00000000 -7.5938193 0.07068750 0.19993333 0.000000000 -0.19993333 2.384932e-14 5.096682e-16 FALSE TRUE
MSTRG.4740.18 ENSG00000120008 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR11 protein_coding   21.35278 9.563793 32.93294 0.4167664 0.8487234 1.782807 0.7173015 1.1612362 0.3232679 0.58078070 0.12039982 -1.8132779 0.05237083 0.11700000 0.009733333 -0.10726667 4.214744e-01 5.096682e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120008 E001 0.2924217 0.0273379285 8.198928e-01   10 120851305 120851312 8 + 0.131 0.000 -10.302
ENSG00000120008 E002 0.4375944 0.0267185100 4.871097e-01 6.248068e-01 10 120851313 120851316 4 + 0.184 0.000 -10.867
ENSG00000120008 E003 2.1317679 0.0081587883 5.425003e-01 6.732505e-01 10 120851317 120851361 45 + 0.412 0.533 0.606
ENSG00000120008 E004 14.5303075 0.0303568723 6.826279e-01 7.860430e-01 10 120851362 120851391 30 + 1.141 1.101 -0.144
ENSG00000120008 E005 20.6701846 0.0284053210 8.583092e-02 1.687180e-01 10 120851392 120851403 12 + 1.320 1.122 -0.699
ENSG00000120008 E006 41.3714720 0.0005226179 7.219723e-05 3.908443e-04 10 120851404 120851486 83 + 1.625 1.367 -0.887
ENSG00000120008 E007 34.8207003 0.0024759651 1.725027e-04 8.459700e-04 10 120851487 120851506 20 + 1.559 1.280 -0.965
ENSG00000120008 E008 6.5148254 0.0028714792 1.751511e-02 4.607311e-02 10 120851507 120851527 21 + 0.896 0.532 -1.512
ENSG00000120008 E009 2.9507565 0.0052294513 8.128996e-01 8.813728e-01 10 120851528 120851591 64 + 0.561 0.532 -0.133
ENSG00000120008 E010 5.4817904 0.0029292606 3.279642e-01 4.714287e-01 10 120851781 120852523 743 + 0.798 0.664 -0.549
ENSG00000120008 E011 63.7027833 0.0005387364 2.678311e-07 2.503568e-06 10 120852524 120852603 80 + 1.811 1.533 -0.945
ENSG00000120008 E012 45.2575998 0.0027325711 9.224504e-05 4.855262e-04 10 120852604 120852615 12 + 1.662 1.400 -0.897
ENSG00000120008 E013 48.5134781 0.0024006084 4.640863e-05 2.635247e-04 10 120852616 120852635 20 + 1.692 1.430 -0.897
ENSG00000120008 E014 0.5848434 0.0247253270 3.221734e-01 4.654773e-01 10 120856082 120856130 49 + 0.231 0.000 -11.282
ENSG00000120008 E015 67.2543961 0.0023456320 1.099093e-06 9.043990e-06 10 120858643 120858703 61 + 1.836 1.562 -0.931
ENSG00000120008 E016 81.6696670 0.0054205848 1.665989e-06 1.318090e-05 10 120858704 120858796 93 + 1.920 1.635 -0.962
ENSG00000120008 E017 114.5649405 0.0030549708 8.327478e-06 5.634744e-05 10 120860109 120860282 174 + 2.051 1.847 -0.686
ENSG00000120008 E018 1.4842573 0.0426343547 2.934569e-01 4.345155e-01 10 120860283 120860310 28 + 0.412 0.204 -1.401
ENSG00000120008 E019 1.7253960 0.0084059191 7.652395e-01 8.480641e-01 10 120862450 120862734 285 + 0.382 0.448 0.359
ENSG00000120008 E020 104.7286942 0.0084848556 8.401370e-02 1.658260e-01 10 120862735 120862921 187 + 1.990 1.897 -0.313
ENSG00000120008 E021 83.2912673 0.0004411230 4.283886e-03 1.393754e-02 10 120865047 120865212 166 + 1.898 1.782 -0.391
ENSG00000120008 E022 95.5221223 0.0003208774 1.629359e-07 1.589317e-06 10 120865630 120865744 115 + 1.977 1.756 -0.745
ENSG00000120008 E023 57.7248650 0.0114854242 1.752333e-02 4.609153e-02 10 120866569 120866574 6 + 1.752 1.583 -0.574
ENSG00000120008 E024 132.4033735 0.0023441731 4.790458e-08 5.190379e-07 10 120866575 120866764 190 + 2.120 1.889 -0.775
ENSG00000120008 E025 35.2448472 0.0105593677 4.109878e-02 9.306655e-02 10 120867066 120867068 3 + 1.543 1.378 -0.570
ENSG00000120008 E026 80.8880785 0.0009592236 2.497365e-03 8.755477e-03 10 120867069 120867169 101 + 1.888 1.756 -0.445
ENSG00000120008 E027 0.0000000       10 120868663 120868761 99 +      
ENSG00000120008 E028 85.4188322 0.0040569016 2.245252e-01 3.558573e-01 10 120871170 120871234 65 + 1.891 1.841 -0.171
ENSG00000120008 E029 100.5650432 0.0087997748 4.588605e-01 5.991023e-01 10 120871235 120871346 112 + 1.958 1.927 -0.104
ENSG00000120008 E030 93.2847493 0.0180978668 1.941839e-02 5.024113e-02 10 120873839 120873923 85 + 1.957 1.784 -0.583
ENSG00000120008 E031 124.1689679 0.0005092721 7.749145e-05 4.161972e-04 10 120878353 120878459 107 + 2.073 1.934 -0.466
ENSG00000120008 E032 9.4031026 0.0018962194 3.885468e-04 1.730480e-03 10 120879005 120880562 1558 + 1.050 0.532 -2.084
ENSG00000120008 E033 87.1959674 0.0046234855 1.820358e-03 6.664633e-03 10 120880826 120880901 76 + 1.927 1.765 -0.547
ENSG00000120008 E034 106.1774103 0.0076930326 4.436529e-02 9.904981e-02 10 120883780 120883888 109 + 2.001 1.900 -0.340
ENSG00000120008 E035 0.2966881 0.0270331423 8.205341e-01   10 120885010 120885125 116 + 0.131 0.000 -10.283
ENSG00000120008 E036 81.0372370 0.0004382049 7.274789e-01 8.201736e-01 10 120885814 120885867 54 + 1.852 1.885 0.114
ENSG00000120008 E037 99.0255545 0.0003048803 8.980267e-01 9.389040e-01 10 120885868 120885938 71 + 1.944 1.957 0.044
ENSG00000120008 E038 133.4875109 0.0003106959 1.023583e-01 1.941200e-01 10 120886689 120886836 148 + 2.086 2.046 -0.136
ENSG00000120008 E039 97.8665211 0.0003153506 3.529962e-01 4.972419e-01 10 120889078 120889184 107 + 1.948 1.927 -0.068
ENSG00000120008 E040 2.1369792 0.0068845641 6.580031e-01 7.672436e-01 10 120889185 120889894 710 + 0.441 0.532 0.451
ENSG00000120008 E041 135.6394292 0.0035487124 6.986539e-01 7.985633e-01 10 120889895 120890009 115 + 2.080 2.083 0.008
ENSG00000120008 E042 154.8679731 0.0002768451 2.694678e-01 4.079811e-01 10 120890716 120890887 172 + 2.124 2.178 0.180
ENSG00000120008 E043 0.8062886 0.0245998476 8.793164e-01 9.264783e-01 10 120899838 120900028 191 + 0.231 0.205 -0.223
ENSG00000120008 E044 122.3963457 0.0003479431 8.878083e-01 9.322851e-01 10 120900029 120900137 109 + 2.033 2.046 0.043
ENSG00000120008 E045 78.9043730 0.0070762322 5.505802e-01 6.801944e-01 10 120901036 120901098 63 + 1.834 1.888 0.182
ENSG00000120008 E046 75.3207103 0.0003704745 2.184967e-02 5.536782e-02 10 120902257 120902322 66 + 1.794 1.915 0.407
ENSG00000120008 E047 145.6270742 0.0002317002 1.116709e-02 3.156767e-02 10 120903055 120903232 178 + 2.083 2.184 0.337
ENSG00000120008 E048 0.4762024 0.2869748391 6.722203e-01 7.782654e-01 10 120904041 120904046 6 + 0.131 0.205 0.780
ENSG00000120008 E049 69.2250705 0.0004180033 1.738204e-01 2.931570e-01 10 120904047 120904064 18 + 1.771 1.854 0.277
ENSG00000120008 E050 106.8252648 0.0009627505 2.301016e-01 3.625903e-01 10 120904065 120904142 78 + 1.960 2.026 0.221
ENSG00000120008 E051 0.1451727 0.0434388323 1.000000e+00   10 120904143 120904150 8 + 0.070 0.000 -9.283
ENSG00000120008 E052 58.6104557 0.0018636150 6.714151e-02 1.386047e-01 10 120904646 120904649 4 + 1.688 1.803 0.391
ENSG00000120008 E053 151.2729157 0.0003324008 7.244733e-04 2.986927e-03 10 120904650 120904811 162 + 2.090 2.217 0.422
ENSG00000120008 E054 59.3823280 0.0042692907 1.580425e-01 2.725250e-01 10 120905319 120905320 2 + 1.699 1.799 0.338
ENSG00000120008 E055 122.5708695 0.0004668986 6.465436e-04 2.703701e-03 10 120905321 120905416 96 + 1.997 2.136 0.469
ENSG00000120008 E056 17.5646639 0.0026810422 7.702933e-01 8.516422e-01 10 120905417 120905656 240 + 1.217 1.205 -0.041
ENSG00000120008 E057 139.1719253 0.0035323175 9.802111e-04 3.892130e-03 10 120905876 120906021 146 + 2.046 2.206 0.536
ENSG00000120008 E058 70.2764682 0.0004257251 4.674347e-05 2.652512e-04 10 120906022 120906775 754 + 1.734 1.937 0.685
ENSG00000120008 E059 115.5760775 0.0015467586 1.895243e-07 1.824338e-06 10 120906776 120906855 80 + 1.942 2.164 0.745
ENSG00000120008 E060 26.1444889 0.0145361506 5.471249e-03 1.721180e-02 10 120907295 120908555 1261 + 1.290 1.557 0.923
ENSG00000120008 E061 418.7022491 0.0038784007 2.358042e-23 2.164360e-21 10 120908556 120909524 969 + 2.449 2.792 1.142