ENSG00000119979

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361432 ENSG00000119979 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND10 protein_coding protein_coding 17.80249 19.75364 23.41369 1.907973 1.272421 0.2451196 1.823907 0.9981726 2.917105 0.0481870 0.35075726 1.5377317 0.09873333 0.0518000 0.12376667 0.07196667 3.752112e-04 6.982796e-64 FALSE TRUE
ENST00000472379 ENSG00000119979 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND10 protein_coding protein_coding 17.80249 19.75364 23.41369 1.907973 1.272421 0.2451196 1.438083 2.2521277 1.304515 0.2502477 0.07499188 -0.7831493 0.09536250 0.1142667 0.05636667 -0.05790000 2.729438e-03 6.982796e-64   FALSE
ENST00000487888 ENSG00000119979 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND10 protein_coding processed_transcript 17.80249 19.75364 23.41369 1.907973 1.272421 0.2451196 6.605212 2.0189028 14.239065 1.3153122 0.51547523 2.8120956 0.33487917 0.0914000 0.60956667 0.51816667 9.624299e-02 6.982796e-64 FALSE FALSE
ENST00000497903 ENSG00000119979 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND10 protein_coding processed_transcript 17.80249 19.75364 23.41369 1.907973 1.272421 0.2451196 3.296466 10.5306568 0.000000 1.5824721 0.00000000 -10.0417491 0.19185000 0.5278000 0.00000000 -0.52780000 6.982796e-64 6.982796e-64   FALSE
MSTRG.4716.8 ENSG00000119979 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND10 protein_coding   17.80249 19.75364 23.41369 1.907973 1.272421 0.2451196 2.649682 2.3258271 2.497263 1.2407802 0.33663841 0.1021797 0.15569167 0.1319000 0.10570000 -0.02620000 9.407345e-01 6.982796e-64 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119979 E001 0.1515154 0.0438009577 6.626155e-01   10 119104059 119104061 3 + 0.102 0.001 -7.547
ENSG00000119979 E002 1.5070699 0.2718313624 8.459551e-01 9.042336e-01 10 119104062 119104084 23 + 0.367 0.420 0.296
ENSG00000119979 E003 1.6887742 0.3530916818 7.160713e-01 8.118151e-01 10 119104085 119104085 1 + 0.367 0.484 0.624
ENSG00000119979 E004 1.6887742 0.3530916818 7.160713e-01 8.118151e-01 10 119104086 119104086 1 + 0.367 0.484 0.624
ENSG00000119979 E005 1.6887742 0.3530916818 7.160713e-01 8.118151e-01 10 119104087 119104087 1 + 0.367 0.484 0.624
ENSG00000119979 E006 2.4240864 0.1954867343 6.075300e-01 7.274837e-01 10 119104088 119104090 3 + 0.456 0.591 0.641
ENSG00000119979 E007 2.7196286 0.1200177412 5.290502e-01 6.619006e-01 10 119104091 119104091 1 + 0.495 0.629 0.616
ENSG00000119979 E008 2.7196286 0.1200177412 5.290502e-01 6.619006e-01 10 119104092 119104092 1 + 0.495 0.629 0.616
ENSG00000119979 E009 4.2060759 0.0132545639 4.950403e-01 6.319158e-01 10 119104093 119104093 1 + 0.741 0.662 -0.328
ENSG00000119979 E010 15.2475136 0.0012515861 2.749251e-05 1.650152e-04 10 119104094 119104094 1 + 0.990 1.383 1.401
ENSG00000119979 E011 20.8562654 0.0015923579 3.159814e-07 2.910147e-06 10 119104095 119104103 9 + 1.094 1.518 1.483
ENSG00000119979 E012 24.8508579 0.0102586803 7.520051e-07 6.415902e-06 10 119104104 119104112 9 + 1.155 1.599 1.546
ENSG00000119979 E013 28.9658570 0.0164485544 7.313620e-07 6.256404e-06 10 119104113 119104116 4 + 1.201 1.672 1.628
ENSG00000119979 E014 167.3006594 0.0053535547 2.194272e-22 1.823238e-20 10 119104117 119104197 81 + 1.971 2.409 1.464
ENSG00000119979 E015 184.8266558 0.0002348082 1.280174e-138 1.212625e-134 10 119104764 119105006 243 + 1.802 2.523 2.415
ENSG00000119979 E016 7.0428892 0.0024176937 5.206392e-01 6.545894e-01 10 119105007 119105022 16 + 0.852 0.953 0.386
ENSG00000119979 E017 9.4457162 0.0019258193 7.533936e-04 3.091763e-03 10 119105023 119105310 288 + 0.800 1.186 1.436
ENSG00000119979 E018 15.5958535 0.0029401324 1.640418e-01 2.804095e-01 10 119105311 119105495 185 + 1.138 1.287 0.528
ENSG00000119979 E019 5.1849939 0.0646828961 5.160579e-01 6.506521e-01 10 119105496 119105643 148 + 0.721 0.848 0.505
ENSG00000119979 E020 20.4621994 0.0046992458 3.612073e-06 2.656224e-05 10 119107948 119107967 20 + 1.460 1.085 -1.320
ENSG00000119979 E021 101.8723797 0.0003092990 1.035740e-23 9.950199e-22 10 119107968 119108164 197 + 2.131 1.790 -1.145
ENSG00000119979 E022 0.8847512 0.2042392462 9.566721e-01 9.768291e-01 10 119110193 119110314 122 + 0.254 0.260 0.042
ENSG00000119979 E023 70.4385137 0.0004133002 3.347229e-16 1.348336e-14 10 119111849 119111928 80 + 1.970 1.636 -1.128
ENSG00000119979 E024 0.0000000       10 119114105 119114611 507 +      
ENSG00000119979 E025 95.2237473 0.0003241238 4.212727e-20 2.707220e-18 10 119117519 119117667 149 + 2.095 1.776 -1.074
ENSG00000119979 E026 47.2429786 0.0007557261 2.835499e-06 2.134025e-05 10 119120341 119120381 41 + 1.764 1.543 -0.751
ENSG00000119979 E027 61.4508907 0.0029750979 6.019769e-09 7.746414e-08 10 119120382 119120452 71 + 1.893 1.613 -0.949
ENSG00000119979 E028 69.9277913 0.0017174222 1.662128e-08 1.966926e-07 10 119123469 119123569 101 + 1.938 1.703 -0.794
ENSG00000119979 E029 1.0402304 0.4438690630 4.967040e-01 6.333253e-01 10 119129475 119129514 40 + 0.185 0.455 1.798
ENSG00000119979 E030 69.9302595 0.0004533335 1.305233e-09 1.893937e-08 10 119129515 119129622 108 + 1.938 1.703 -0.794
ENSG00000119979 E031 68.2484571 0.0003974237 2.836589e-09 3.868293e-08 10 119132515 119132609 95 + 1.928 1.696 -0.781
ENSG00000119979 E032 2.2205500 0.1951826408 4.317643e-01 5.742802e-01 10 119132610 119133015 406 + 0.415 0.614 0.961
ENSG00000119979 E033 8.2162305 0.0690652542 1.734455e-02 4.569996e-02 10 119133016 119134128 1113 + 0.741 1.145 1.524
ENSG00000119979 E034 2.2530071 0.0095597631 2.357221e-01 3.692297e-01 10 119134446 119135180 735 + 0.593 0.414 -0.874
ENSG00000119979 E035 38.3895619 0.0005994901 6.301987e-06 4.385924e-05 10 119136471 119136516 46 + 1.684 1.449 -0.801
ENSG00000119979 E036 74.6683042 0.0019188266 5.080936e-04 2.190289e-03 10 119136517 119136920 404 + 1.932 1.805 -0.425
ENSG00000119979 E037 75.4247884 0.0014503996 1.762096e-05 1.106476e-04 10 119136921 119137056 136 + 1.948 1.789 -0.533
ENSG00000119979 E038 95.2186650 0.0183562585 8.335222e-02 1.648157e-01 10 119137057 119140280 3224 + 2.020 1.930 -0.301