ENSG00000119977

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371217 ENSG00000119977 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN3 protein_coding protein_coding 50.77232 53.96976 44.09859 3.644433 0.6205532 -0.2913589 31.632058 37.6441379 23.066413 2.4613800 1.8153616 -0.7063894 0.61740417 0.6981333333 0.52326667 -0.17486667 1.288960e-02 9.167805e-39 FALSE TRUE
MSTRG.4418.16 ENSG00000119977 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN3 protein_coding   50.77232 53.96976 44.09859 3.644433 0.6205532 -0.2913589 4.353183 0.3879122 4.387955 0.2329845 2.3586865 3.4663110 0.08900000 0.0079000000 0.09883333 0.09093333 5.468369e-01 9.167805e-39 FALSE TRUE
MSTRG.4418.17 ENSG00000119977 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN3 protein_coding   50.77232 53.96976 44.09859 3.644433 0.6205532 -0.2913589 1.673039 0.0266479 3.394705 0.0266479 0.1489066 6.5376556 0.03529167 0.0004333333 0.07700000 0.07656667 9.167805e-39 9.167805e-39 FALSE TRUE
MSTRG.4418.4 ENSG00000119977 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN3 protein_coding   50.77232 53.96976 44.09859 3.644433 0.6205532 -0.2913589 6.447152 9.0636229 6.844119 0.1872152 0.3852730 -0.4047075 0.12743750 0.1699666667 0.15520000 -0.01476667 8.069613e-01 9.167805e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119977 E001 46.2994002 0.0045779618 1.675888e-13 4.621426e-12 10 95659823 95663400 3578 - 1.887 1.449 -1.488
ENSG00000119977 E002 3.4071730 0.0049267947 4.630515e-01 6.028914e-01 10 95663401 95663411 11 - 0.697 0.594 -0.443
ENSG00000119977 E003 3.5618090 0.0325342643 6.079073e-01 7.277945e-01 10 95663412 95663413 2 - 0.697 0.621 -0.326
ENSG00000119977 E004 11.5886491 0.0602589969 8.681769e-01 9.192213e-01 10 95663414 95663416 3 - 1.071 1.096 0.091
ENSG00000119977 E005 25.9295892 0.0375637207 2.555701e-01 3.924726e-01 10 95663417 95663434 18 - 1.321 1.463 0.492
ENSG00000119977 E006 26.3189205 0.0208889788 1.227046e-01 2.238207e-01 10 95663435 95663446 12 - 1.312 1.477 0.572
ENSG00000119977 E007 29.4681298 0.0248074004 3.128680e-01 4.553889e-01 10 95663447 95663450 4 - 1.396 1.509 0.386
ENSG00000119977 E008 116.9241747 0.0131275499 7.779887e-05 4.176707e-04 10 95663451 95663519 69 - 1.859 2.136 0.930
ENSG00000119977 E009 336.5111758 0.0063714152 2.651892e-08 3.017738e-07 10 95663520 95663695 176 - 2.334 2.585 0.838
ENSG00000119977 E010 234.1282107 0.0009035971 3.651664e-19 2.118177e-17 10 95663696 95663747 52 - 2.166 2.435 0.898
ENSG00000119977 E011 304.6381717 0.0033644250 1.009402e-10 1.779860e-09 10 95663748 95663854 107 - 2.302 2.539 0.790
ENSG00000119977 E012 930.6674938 0.0010268572 4.859396e-06 3.470680e-05 10 95663855 95664300 446 - 2.893 2.982 0.296
ENSG00000119977 E013 2.0521819 0.0073650438 2.914675e-01 4.323404e-01 10 95669047 95669157 111 - 0.341 0.531 1.005
ENSG00000119977 E014 0.2934659 0.0287573021 7.572293e-01   10 95675343 95675385 43 - 0.145 0.102 -0.582
ENSG00000119977 E015 8.4654641 0.0151569154 4.176617e-01 5.609895e-01 10 95678273 95678526 254 - 0.890 1.001 0.413
ENSG00000119977 E016 441.9401656 0.0001397441 4.499729e-01 5.911529e-01 10 95680472 95680609 138 - 2.617 2.638 0.071
ENSG00000119977 E017 1.3149733 0.2715212797 4.647549e-03 1.495227e-02 10 95680610 95680763 154 - 0.659 0.000 -13.328
ENSG00000119977 E018 491.3082166 0.0001426979 3.552197e-02 8.265613e-02 10 95682651 95682804 154 - 2.648 2.692 0.145
ENSG00000119977 E019 6.7398367 0.1526165975 1.941505e-01 3.189824e-01 10 95682805 95683100 296 - 1.007 0.797 -0.801
ENSG00000119977 E020 402.3992447 0.0001423293 8.677220e-01 9.189143e-01 10 95683101 95683180 80 - 2.588 2.593 0.018
ENSG00000119977 E021 244.4937108 0.0002102642 8.478306e-02 1.670593e-01 10 95683181 95683195 15 - 2.397 2.366 -0.106
ENSG00000119977 E022 4.9231635 0.0799109551 6.106159e-01 7.299257e-01 10 95683196 95683260 65 - 0.697 0.809 0.453
ENSG00000119977 E023 15.1781534 0.0013233327 7.433750e-01 8.320198e-01 10 95683261 95683521 261 - 1.207 1.187 -0.074
ENSG00000119977 E024 435.1358154 0.0001860345 5.068302e-01 6.424738e-01 10 95683522 95683629 108 - 2.612 2.632 0.067
ENSG00000119977 E025 280.1583237 0.0003531627 5.133921e-01 6.482166e-01 10 95684499 95684519 21 - 2.439 2.432 -0.023
ENSG00000119977 E026 272.1564366 0.0002108470 6.434477e-01 7.560010e-01 10 95684520 95684532 13 - 2.424 2.422 -0.007
ENSG00000119977 E027 408.9923574 0.0001443305 5.086247e-01 6.440100e-01 10 95684533 95684624 92 - 2.584 2.604 0.067
ENSG00000119977 E028 15.8342215 0.0118155070 2.548047e-05 1.541837e-04 10 95684625 95685555 931 - 1.423 1.014 -1.448
ENSG00000119977 E029 297.4029894 0.0001687721 8.493386e-01 9.064795e-01 10 95685556 95685630 75 - 2.456 2.460 0.014
ENSG00000119977 E030 166.2008959 0.0003290722 2.341238e-01 3.672940e-01 10 95685631 95685636 6 - 2.225 2.198 -0.087
ENSG00000119977 E031 11.9150310 0.0173195348 9.376779e-05 4.926515e-04 10 95685637 95686494 858 - 1.320 0.885 -1.575
ENSG00000119977 E032 274.2302700 0.0006863939 6.640813e-01 7.719669e-01 10 95686495 95686530 36 - 2.412 2.430 0.059
ENSG00000119977 E033 258.9746179 0.0001781587 5.833052e-01 7.074384e-01 10 95687044 95687081 38 - 2.401 2.397 -0.015
ENSG00000119977 E034 324.3110234 0.0001507085 6.408429e-01 7.540086e-01 10 95687082 95687159 78 - 2.498 2.497 -0.004
ENSG00000119977 E035 389.7244055 0.0002229001 7.617076e-04 3.120947e-03 10 95687247 95687355 109 - 2.612 2.556 -0.186
ENSG00000119977 E036 412.9155931 0.0006147682 3.877298e-06 2.829626e-05 10 95687592 95687719 128 - 2.655 2.566 -0.296
ENSG00000119977 E037 2.0681703 0.0068358859 8.906045e-07 7.476508e-06 10 95692864 95692919 56 - 0.818 0.000 -13.973
ENSG00000119977 E038 374.8021996 0.0039946971 2.111169e-04 1.011391e-03 10 95692920 95693038 119 - 2.633 2.507 -0.421
ENSG00000119977 E039 373.7657213 0.0009530900 1.640002e-13 4.527078e-12 10 95693353 95693476 124 - 2.655 2.491 -0.546
ENSG00000119977 E040 3.5286275 0.1981400514 2.146943e-01 3.440786e-01 10 95693477 95693643 167 - 0.820 0.496 -1.395
ENSG00000119977 E041 447.7541890 0.0009288788 4.021491e-18 2.056300e-16 10 95693644 95694143 500 - 2.743 2.560 -0.607