ENSG00000119965

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000470158 ENSG00000119965 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88 protein_coding processed_transcript 8.18585 2.781122 12.4447 0.3721495 0.1075449 2.157773 2.536693 0.000000 3.952495 0.0000000 0.4372511 8.630265 0.23372917 0.0000 0.3176333 0.3176333 1.084996e-14 1.084996e-14 FALSE FALSE
ENST00000481909 ENSG00000119965 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88 protein_coding protein_coding 8.18585 2.781122 12.4447 0.3721495 0.1075449 2.157773 4.268815 2.698020 6.217274 0.4026544 0.2668363 1.201362 0.63585417 0.9678 0.4998667 -0.4679333 2.071589e-03 1.084996e-14 FALSE TRUE
MSTRG.4763.3 ENSG00000119965 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88 protein_coding   8.18585 2.781122 12.4447 0.3721495 0.1075449 2.157773 1.049644 0.083102 1.876240 0.0831020 0.4435435 4.340557 0.08560417 0.0322 0.1504333 0.1182333 1.472443e-01 1.084996e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119965 E001 0.0000000       10 122930901 122930902 2 -      
ENSG00000119965 E002 141.7066706 0.0002474276 2.052053e-20 1.378758e-18 10 122930903 122932258 1356 - 2.031 2.283 0.841
ENSG00000119965 E003 38.8112923 0.0005326121 3.267198e-02 7.714830e-02 10 122932259 122932408 150 - 1.528 1.648 0.411
ENSG00000119965 E004 55.8254060 0.0005170783 3.435210e-01 4.875602e-01 10 122932409 122932602 194 - 1.708 1.752 0.148
ENSG00000119965 E005 32.4626227 0.0061308433 5.770323e-01 7.023711e-01 10 122932603 122932661 59 - 1.505 1.458 -0.161
ENSG00000119965 E006 0.7385489 0.0608988596 1.904011e-01 3.142614e-01 10 122933374 122933459 86 - 0.295 0.001 -9.416
ENSG00000119965 E007 63.3344556 0.0013308465 8.885765e-02 1.733695e-01 10 122937705 122937850 146 - 1.800 1.712 -0.298
ENSG00000119965 E008 102.3129045 0.0003814160 4.858393e-04 2.106052e-03 10 122937851 122938159 309 - 2.019 1.884 -0.453
ENSG00000119965 E009 56.2993350 0.0036656733 5.708673e-02 1.216170e-01 10 122948649 122948755 107 - 1.758 1.646 -0.378
ENSG00000119965 E010 46.6746621 0.0004528389 1.578219e-01 2.722263e-01 10 122948756 122948855 100 - 1.668 1.586 -0.280
ENSG00000119965 E011 35.6772276 0.0006479302 7.983173e-03 2.373565e-02 10 122951954 122952026 73 - 1.577 1.397 -0.621
ENSG00000119965 E012 59.0790676 0.0004642054 1.878020e-02 4.885348e-02 10 122952829 122953028 200 - 1.777 1.654 -0.416
ENSG00000119965 E013 21.0410601 0.0615533820 5.582657e-01 6.865445e-01 10 122953029 122953032 4 - 1.330 1.235 -0.334
ENSG00000119965 E014 38.3682223 0.0024824660 1.289952e-01 2.327715e-01 10 122954015 122954311 297 - 1.588 1.483 -0.362