ENSG00000119953

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369592 ENSG00000119953 HEK293_OSMI2_2hA HEK293_TMG_2hB SMNDC1 protein_coding protein_coding 31.41378 20.47096 42.95656 1.499389 0.5521836 1.068931 13.314871 7.695316 19.714939 0.3927346 0.7473199 1.3560947 0.4153042 0.37960000 0.4586667 0.07906667 0.24709763 0.01758105 FALSE TRUE
ENST00000369603 ENSG00000119953 HEK293_OSMI2_2hA HEK293_TMG_2hB SMNDC1 protein_coding protein_coding 31.41378 20.47096 42.95656 1.499389 0.5521836 1.068931 11.953689 10.989891 14.587938 1.6919385 0.8082249 0.4082754 0.4047250 0.53283333 0.3392333 -0.19360000 0.01758105 0.01758105 FALSE TRUE
ENST00000460483 ENSG00000119953 HEK293_OSMI2_2hA HEK293_TMG_2hB SMNDC1 protein_coding processed_transcript 31.41378 20.47096 42.95656 1.499389 0.5521836 1.068931 4.841495 1.442775 6.850934 0.5824004 0.6129375 2.2395942 0.1429083 0.07166667 0.1599333 0.08826667 0.14684682 0.01758105 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119953 E001 1034.6739704 0.0032833631 4.035782e-06 2.932408e-05 10 110290730 110294061 3332 - 2.952 3.081 0.430
ENSG00000119953 E002 391.7382708 0.0002076612 2.272806e-03 8.067758e-03 10 110294062 110294287 226 - 2.556 2.642 0.286
ENSG00000119953 E003 157.7282702 0.0014277131 6.789979e-01 7.833036e-01 10 110295228 110295229 2 - 2.183 2.225 0.140
ENSG00000119953 E004 391.4052246 0.0002754164 9.227776e-02 1.786842e-01 10 110295230 110295381 152 - 2.594 2.595 0.001
ENSG00000119953 E005 155.6314906 0.0003127713 8.465634e-02 1.668458e-01 10 110297567 110297569 3 - 2.206 2.188 -0.058
ENSG00000119953 E006 408.6634635 0.0009708270 2.230594e-03 7.938000e-03 10 110297570 110297728 159 - 2.628 2.591 -0.124
ENSG00000119953 E007 10.8619056 0.0035014028 1.801281e-03 6.603209e-03 10 110297729 110297745 17 - 1.178 0.868 -1.140
ENSG00000119953 E008 209.3886310 0.0012127646 1.385493e-02 3.789632e-02 10 110298648 110298676 29 - 2.341 2.299 -0.139
ENSG00000119953 E009 263.8801639 0.0017518379 4.018333e-06 2.921410e-05 10 110298677 110298790 114 - 2.466 2.360 -0.352
ENSG00000119953 E010 0.4375944 0.0262040671 1.546106e-01 2.678848e-01 10 110298791 110298810 20 - 0.254 0.000 -10.461
ENSG00000119953 E011 7.6709673 0.0292411837 2.432322e-02 6.048146e-02 10 110300547 110300736 190 - 1.045 0.760 -1.087
ENSG00000119953 E012 170.8551416 0.0002682786 2.380591e-05 1.451174e-04 10 110303468 110303587 120 - 2.270 2.184 -0.285
ENSG00000119953 E013 1.9626498 0.0086286098 4.270191e-02 9.600025e-02 10 110303588 110304131 544 - 0.593 0.255 -1.874
ENSG00000119953 E014 1.8091717 0.0097494484 6.640169e-02 1.373964e-01 10 110304393 110304747 355 - 0.563 0.255 -1.736
ENSG00000119953 E015 85.5131219 0.0004267415 1.072711e-03 4.210195e-03 10 110304748 110304938 191 - 1.975 1.878 -0.326