ENSG00000119950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239007 ENSG00000119950 HEK293_OSMI2_2hA HEK293_TMG_2hB MXI1 protein_coding protein_coding 13.61221 8.130156 20.05399 0.6351554 0.8006064 1.30148 1.6114589 0.9292118 3.102971 0.1360072 0.4643379 1.7287699 0.12516667 0.1178667 0.1557000 0.03783333 6.565979e-01 5.724143e-27 FALSE TRUE
ENST00000332674 ENSG00000119950 HEK293_OSMI2_2hA HEK293_TMG_2hB MXI1 protein_coding protein_coding 13.61221 8.130156 20.05399 0.6351554 0.8006064 1.30148 3.4334201 2.3934860 3.631375 0.4119094 0.3443271 0.5993548 0.28062917 0.3057000 0.1810667 -0.12463333 3.369418e-01 5.724143e-27 FALSE TRUE
ENST00000650952 ENSG00000119950 HEK293_OSMI2_2hA HEK293_TMG_2hB MXI1 protein_coding protein_coding 13.61221 8.130156 20.05399 0.6351554 0.8006064 1.30148 4.6687718 1.5175927 6.965962 0.7673468 0.3128780 2.1911323 0.30428750 0.1986000 0.3484333 0.14983333 7.009941e-01 5.724143e-27 FALSE TRUE
ENST00000651495 ENSG00000119950 HEK293_OSMI2_2hA HEK293_TMG_2hB MXI1 protein_coding protein_coding 13.61221 8.130156 20.05399 0.6351554 0.8006064 1.30148 0.5165203 2.9183907 0.000000 1.6790625 0.0000000 -8.1939642 0.06437083 0.3303000 0.0000000 -0.33030000 9.776083e-02 5.724143e-27 FALSE TRUE
ENST00000651516 ENSG00000119950 HEK293_OSMI2_2hA HEK293_TMG_2hB MXI1 protein_coding protein_coding 13.61221 8.130156 20.05399 0.6351554 0.8006064 1.30148 2.0414050 0.0000000 4.434040 0.0000000 0.4853405 8.7957280 0.12089583 0.0000000 0.2199333 0.21993333 5.724143e-27 5.724143e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119950 E001 11.2185111 0.0231936611 8.012021e-01 8.733334e-01 10 110207605 110207683 79 + 1.045 1.118 0.265
ENSG00000119950 E002 39.1430923 0.0135265753 5.434470e-01 6.740766e-01 10 110207684 110208082 399 + 1.598 1.598 0.001
ENSG00000119950 E003 0.1817044 0.0436579801 3.212467e-01   10 110210231 110210315 85 + 0.000 0.155 11.804
ENSG00000119950 E004 3.7009362 0.0042094312 1.160648e-06 9.507144e-06 10 110225993 110226034 42 + 0.855 0.000 -16.244
ENSG00000119950 E005 4.7662485 0.0032680679 1.086236e-06 8.947913e-06 10 110226035 110226083 49 + 0.936 0.155 -4.149
ENSG00000119950 E006 9.2690140 0.0017782449 2.480824e-05 1.506168e-04 10 110226084 110226190 107 + 1.140 0.688 -1.726
ENSG00000119950 E007 8.1971315 0.0111526381 2.071361e-04 9.945590e-04 10 110226191 110226203 13 + 1.091 0.647 -1.720
ENSG00000119950 E008 16.7599875 0.0010961010 1.440772e-06 1.156665e-05 10 110226204 110226283 80 + 1.365 0.982 -1.366
ENSG00000119950 E009 0.2934659 0.0282348730 7.622099e-01   10 110226284 110226350 67 + 0.096 0.155 0.802
ENSG00000119950 E010 0.0000000       10 110226351 110226386 36 +      
ENSG00000119950 E011 0.0000000       10 110226590 110226626 37 +      
ENSG00000119950 E012 0.0000000       10 110226777 110226796 20 +      
ENSG00000119950 E013 0.0000000       10 110226805 110226810 6 +      
ENSG00000119950 E014 0.0000000       10 110226811 110226816 6 +      
ENSG00000119950 E015 0.0000000       10 110226817 110226818 2 +      
ENSG00000119950 E016 0.0000000       10 110226819 110226830 12 +      
ENSG00000119950 E017 0.0000000       10 110226831 110226834 4 +      
ENSG00000119950 E018 0.0000000       10 110226835 110226850 16 +      
ENSG00000119950 E019 0.0000000       10 110226851 110226852 2 +      
ENSG00000119950 E020 0.0000000       10 110226853 110226854 2 +      
ENSG00000119950 E021 0.0000000       10 110226855 110226874 20 +      
ENSG00000119950 E022 0.0000000       10 110226875 110226885 11 +      
ENSG00000119950 E023 0.0000000       10 110226995 110227014 20 +      
ENSG00000119950 E024 0.0000000       10 110227074 110227086 13 +      
ENSG00000119950 E025 0.0000000       10 110227087 110227100 14 +      
ENSG00000119950 E026 0.0000000       10 110227101 110227118 18 +      
ENSG00000119950 E027 0.0000000       10 110227125 110227136 12 +      
ENSG00000119950 E028 0.0000000       10 110227137 110227142 6 +      
ENSG00000119950 E029 0.0000000       10 110227143 110227162 20 +      
ENSG00000119950 E030 0.0000000       10 110227179 110227182 4 +      
ENSG00000119950 E031 0.0000000       10 110227183 110227202 20 +      
ENSG00000119950 E032 0.0000000       10 110227203 110227213 11 +      
ENSG00000119950 E033 0.0000000       10 110227306 110227317 12 +      
ENSG00000119950 E034 0.0000000       10 110227318 110227325 8 +      
ENSG00000119950 E035 0.0000000       10 110227326 110227337 12 +      
ENSG00000119950 E036 0.0000000       10 110227338 110227339 2 +      
ENSG00000119950 E037 0.1515154 0.0428864608 7.359419e-01   10 110227340 110227345 6 + 0.096 0.000 -11.701
ENSG00000119950 E038 0.1515154 0.0428864608 7.359419e-01   10 110227346 110227354 9 + 0.096 0.000 -11.701
ENSG00000119950 E039 0.1515154 0.0428864608 7.359419e-01   10 110227355 110227365 11 + 0.096 0.000 -11.701
ENSG00000119950 E040 0.1515154 0.0428864608 7.359419e-01   10 110227366 110227377 12 + 0.096 0.000 -11.701
ENSG00000119950 E041 0.2966881 0.0290785164 3.503575e-01   10 110227378 110227386 9 + 0.174 0.000 -12.791
ENSG00000119950 E042 0.0000000       10 110227387 110227398 12 +      
ENSG00000119950 E043 0.0000000       10 110227399 110227406 8 +      
ENSG00000119950 E044 0.0000000       10 110227413 110227431 19 +      
ENSG00000119950 E045 0.1515154 0.0428864608 7.359419e-01   10 110227478 110227501 24 + 0.096 0.000 -11.701
ENSG00000119950 E046 0.1515154 0.0428864608 7.359419e-01   10 110227510 110227540 31 + 0.096 0.000 -11.701
ENSG00000119950 E047 0.1515154 0.0428864608 7.359419e-01   10 110227541 110227542 2 + 0.096 0.000 -11.701
ENSG00000119950 E048 0.5975289 0.0315356621 9.491171e-02 1.827497e-01 10 110227543 110227642 100 + 0.298 0.000 -13.721
ENSG00000119950 E049 1.0371996 0.0228328999 1.697233e-02 4.487464e-02 10 110227643 110227678 36 + 0.435 0.000 -14.540
ENSG00000119950 E050 2.8722899 0.1579027191 8.595913e-01 9.134236e-01 10 110227679 110227785 107 + 0.539 0.613 0.335
ENSG00000119950 E051 3.7634089 0.1501806712 4.379288e-01 5.798118e-01 10 110227786 110227882 97 + 0.570 0.769 0.844
ENSG00000119950 E052 4.8128135 0.0655819712 5.856745e-01 7.093248e-01 10 110227883 110228188 306 + 0.693 0.824 0.526
ENSG00000119950 E053 33.8291631 0.0148458626 9.998282e-02 1.904686e-01 10 110228189 110228202 14 + 1.570 1.480 -0.307
ENSG00000119950 E054 76.1236516 0.0005325363 9.282299e-04 3.713449e-03 10 110228203 110228321 119 + 1.913 1.836 -0.259
ENSG00000119950 E055 42.0738319 0.0005690821 3.252017e-02 7.684348e-02 10 110244828 110244828 1 + 1.652 1.594 -0.196
ENSG00000119950 E056 57.1384106 0.0004610508 4.238595e-02 9.542240e-02 10 110244829 110244857 29 + 1.773 1.738 -0.119
ENSG00000119950 E057 0.7458221 0.0209872592 3.536003e-01 4.978598e-01 10 110244858 110244873 16 + 0.298 0.155 -1.198
ENSG00000119950 E058 0.5483223 0.0214931015 3.481425e-01 4.923598e-01 10 110245743 110245818 76 + 0.096 0.270 1.808
ENSG00000119950 E059 0.6653823 0.0170742681 5.491802e-01 6.789430e-01 10 110260999 110261145 147 + 0.240 0.156 -0.779
ENSG00000119950 E060 0.0000000       10 110270208 110270571 364 +      
ENSG00000119950 E061 103.7620029 0.0009149637 1.820796e-04 8.868830e-04 10 110279180 110279294 115 + 2.045 1.968 -0.259
ENSG00000119950 E062 0.0000000       10 110279490 110279683 194 +      
ENSG00000119950 E063 137.3708176 0.0002752340 3.393398e-07 3.105648e-06 10 110279914 110280085 172 + 2.173 2.081 -0.309
ENSG00000119950 E064 0.1472490 0.0432945709 7.360136e-01   10 110280086 110280147 62 + 0.096 0.000 -11.698
ENSG00000119950 E065 169.2710959 0.0030637426 7.225645e-04 2.979641e-03 10 110284824 110285146 323 + 2.249 2.185 -0.216
ENSG00000119950 E066 207.6168307 0.0003028538 1.253866e-04 6.384313e-04 10 110285147 110285641 495 + 2.246 2.396 0.500
ENSG00000119950 E067 316.7364087 0.0116739233 1.413091e-08 1.694770e-07 10 110285642 110287365 1724 + 2.340 2.655 1.050