ENSG00000119912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265986 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding protein_coding 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 2.1138494 0.8541665 3.954284 0.5113887 0.1091376 2.197679 0.15401250 0.15726667 0.16240000 0.005133333 8.224581e-01 1.026281e-08 FALSE TRUE
ENST00000371581 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding protein_coding 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 0.6180722 1.6362625 0.000000 0.9314458 0.0000000 -7.363051 0.11170000 0.24900000 0.00000000 -0.249000000 2.305075e-06 1.026281e-08 FALSE TRUE
ENST00000677079 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding protein_coding 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 1.0182364 0.0000000 2.025007 0.0000000 0.3647861 7.668890 0.04518750 0.00000000 0.08286667 0.082866667 1.026281e-08 1.026281e-08 FALSE TRUE
ENST00000677096 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding nonsense_mediated_decay 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 1.3481443 0.6480814 2.204771 0.5341144 0.3779231 1.750820 0.09250000 0.10170000 0.09076667 -0.010933333 7.658026e-01 1.026281e-08 FALSE TRUE
ENST00000679174 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding nonsense_mediated_decay 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 1.8974084 1.4642495 3.096569 0.2582349 0.8113381 1.075341 0.12102917 0.25186667 0.12773333 -0.124133333 3.417011e-01 1.026281e-08 FALSE TRUE
ENST00000679222 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding nonsense_mediated_decay 15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 1.0574929 0.2826352 1.393089 0.1481060 0.9676879 2.261431 0.05292083 0.05193333 0.05653333 0.004600000 9.987559e-01 1.026281e-08 FALSE TRUE
MSTRG.4394.28 ENSG00000119912 HEK293_OSMI2_2hA HEK293_TMG_2hB IDE protein_coding   15.02007 6.04555 24.36635 0.5617333 0.2848127 2.009152 4.0447685 0.4744857 6.761686 0.1533157 0.5609266 3.804989 0.20749167 0.08153333 0.27753333 0.196000000 1.134600e-02 1.026281e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119912 E001 16.3783571 0.0035060788 1.031100e-03 4.065661e-03 10 92451684 92451935 252 - 1.075 1.419 1.213
ENSG00000119912 E002 7.0178375 0.0076747386 2.700448e-03 9.375650e-03 10 92451936 92451936 1 - 0.715 1.134 1.589
ENSG00000119912 E003 29.3797898 0.0656568819 2.111329e-02 5.383885e-02 10 92451937 92452255 319 - 1.277 1.703 1.465
ENSG00000119912 E004 13.6281926 0.1114687021 3.170402e-02 7.527270e-02 10 92452256 92452258 3 - 0.924 1.433 1.821
ENSG00000119912 E005 14.7654463 0.1024559629 7.050662e-03 2.135591e-02 10 92452259 92452265 7 - 0.915 1.502 2.093
ENSG00000119912 E006 14.4761450 0.1206910775 7.209964e-03 2.177055e-02 10 92452266 92452269 4 - 0.888 1.508 2.216
ENSG00000119912 E007 14.6244382 0.1248016130 7.626757e-03 2.284013e-02 10 92452270 92452271 2 - 0.888 1.515 2.240
ENSG00000119912 E008 63.6605540 0.0341126174 2.308755e-05 1.410879e-04 10 92452272 92452375 104 - 1.560 2.072 1.727
ENSG00000119912 E009 50.6019060 0.0241987340 7.096692e-06 4.879671e-05 10 92452376 92452387 12 - 1.479 1.960 1.631
ENSG00000119912 E010 378.4450504 0.0202435227 9.237772e-06 6.189673e-05 10 92452388 92453514 1127 - 2.396 2.755 1.196
ENSG00000119912 E011 186.3104406 0.0001965481 6.003518e-02 1.266634e-01 10 92453515 92454112 598 - 2.178 2.285 0.357
ENSG00000119912 E012 45.7483768 0.0052907158 3.440501e-05 2.015687e-04 10 92454113 92454268 156 - 1.502 1.817 1.069
ENSG00000119912 E013 124.9088182 0.0002900991 6.315929e-04 2.649367e-03 10 92454269 92454539 271 - 1.987 2.158 0.574
ENSG00000119912 E014 2.7217950 0.0776377256 5.891715e-01 7.122520e-01 10 92454540 92455575 1036 - 0.478 0.622 0.666
ENSG00000119912 E015 86.9211100 0.0003003365 6.883581e-02 1.414397e-01 10 92455576 92455643 68 - 1.844 1.973 0.433
ENSG00000119912 E016 4.1822311 0.0037794549 7.296091e-01 8.217634e-01 10 92455644 92456358 715 - 0.639 0.734 0.401
ENSG00000119912 E017 92.4603859 0.0023972486 6.658516e-03 2.033623e-02 10 92456359 92456431 73 - 1.857 2.034 0.597
ENSG00000119912 E018 0.2955422 0.0292234658 3.787316e-01   10 92456432 92456833 402 - 0.067 0.212 1.914
ENSG00000119912 E019 93.8995540 0.0003129750 1.105548e-02 3.129654e-02 10 92461191 92461252 62 - 1.870 2.025 0.520
ENSG00000119912 E020 0.5159433 0.2745022837 6.607297e-01 7.693501e-01 10 92462484 92462604 121 - 0.125 0.216 0.944
ENSG00000119912 E021 184.2490195 0.0002619281 1.549305e-01 2.683212e-01 10 92463731 92464003 273 - 2.176 2.270 0.315
ENSG00000119912 E022 0.8952612 0.0148626241 7.124930e-01 8.092143e-01 10 92465027 92465104 78 - 0.264 0.213 -0.407
ENSG00000119912 E023 155.2902885 0.0002712952 2.567792e-02 6.327466e-02 10 92465676 92465843 168 - 2.131 2.108 -0.078
ENSG00000119912 E024 116.4997957 0.0002654484 3.805711e-02 8.745730e-02 10 92468879 92468990 112 - 2.010 1.982 -0.095
ENSG00000119912 E025 0.2955422 0.0292234658 3.787316e-01   10 92468991 92469462 472 - 0.067 0.212 1.914
ENSG00000119912 E026 0.1482932 0.0410663609 1.347186e-01   10 92469463 92469587 125 - 0.000 0.212 14.061
ENSG00000119912 E027 0.3299976 0.0258893114 2.841866e-02   10 92469588 92469833 246 - 0.000 0.355 15.132
ENSG00000119912 E028 0.4418608 0.0260240250 5.010531e-01 6.372365e-01 10 92469834 92470253 420 - 0.177 0.000 -12.501
ENSG00000119912 E029 105.6027825 0.0013981742 1.246909e-01 2.266930e-01 10 92470254 92470345 92 - 1.965 1.949 -0.055
ENSG00000119912 E030 0.0000000       10 92472979 92474471 1493 -      
ENSG00000119912 E031 2.5318090 0.1933137752 1.004774e-01 1.911845e-01 10 92474472 92474840 369 - 0.369 0.744 1.766
ENSG00000119912 E032 99.3159720 0.0102180143 9.249984e-01 9.567753e-01 10 92474841 92474961 121 - 1.920 1.971 0.174
ENSG00000119912 E033 58.8377669 0.0228540050 6.179676e-01 7.357081e-01 10 92475884 92475944 61 - 1.682 1.777 0.321
ENSG00000119912 E034 57.2367859 0.0260776339 7.528168e-01 8.389099e-01 10 92475945 92475994 50 - 1.690 1.712 0.077
ENSG00000119912 E035 0.1451727 0.0434910209 1.000000e+00   10 92475995 92476197 203 - 0.067 0.000 -10.944
ENSG00000119912 E036 1.7025940 0.0082305155 7.476020e-01 8.350685e-01 10 92478645 92478789 145 - 0.369 0.462 0.501
ENSG00000119912 E037 110.2774393 0.0118344097 1.205833e-01 2.208017e-01 10 92479277 92479421 145 - 1.990 1.936 -0.181
ENSG00000119912 E038 11.7065719 0.0028040451 1.483412e-02 4.011535e-02 10 92479422 92480556 1135 - 1.087 0.826 -0.979
ENSG00000119912 E039 4.3218563 0.3294101747 4.897585e-01 6.271471e-01 10 92480557 92480792 236 - 0.688 0.569 -0.518
ENSG00000119912 E040 5.1090176 0.0031766307 1.142965e-01 2.118058e-01 10 92480793 92480916 124 - 0.768 0.548 -0.941
ENSG00000119912 E041 0.1472490 0.0442260810 1.000000e+00   10 92482949 92482967 19 - 0.067 0.000 -10.944
ENSG00000119912 E042 0.4396707 0.0302818011 5.009658e-01 6.371700e-01 10 92482968 92483194 227 - 0.177 0.000 -12.505
ENSG00000119912 E043 0.4396707 0.0302818011 5.009658e-01 6.371700e-01 10 92483195 92483254 60 - 0.177 0.000 -12.505
ENSG00000119912 E044 89.5485009 0.0139944467 1.119328e-01 2.083981e-01 10 92483255 92483337 83 - 1.904 1.835 -0.231
ENSG00000119912 E045 107.9604015 0.0182979542 1.790499e-01 2.999448e-01 10 92487196 92487318 123 - 1.981 1.929 -0.175
ENSG00000119912 E046 105.2107336 0.0340955713 3.091177e-01 4.513816e-01 10 92490493 92490595 103 - 1.965 1.933 -0.109
ENSG00000119912 E047 0.0000000       10 92497672 92497761 90 -      
ENSG00000119912 E048 103.7142217 0.0093094628 2.047342e-02 5.248694e-02 10 92504794 92504897 104 - 1.972 1.876 -0.324
ENSG00000119912 E049 94.3701899 0.0004354797 2.676358e-06 2.025762e-05 10 92506442 92506522 81 - 1.946 1.781 -0.554
ENSG00000119912 E050 0.1472490 0.0442260810 1.000000e+00   10 92506523 92507574 1052 - 0.067 0.000 -10.944
ENSG00000119912 E051 84.3416786 0.0008375641 2.673868e-07 2.500154e-06 10 92507575 92507666 92 - 1.906 1.696 -0.708
ENSG00000119912 E052 0.1515154 0.0436160905 1.000000e+00   10 92507667 92508112 446 - 0.067 0.000 -10.944
ENSG00000119912 E053 97.3521607 0.0025203529 5.961515e-07 5.195708e-06 10 92508113 92508205 93 - 1.968 1.759 -0.706
ENSG00000119912 E054 0.0000000       10 92508206 92508516 311 -      
ENSG00000119912 E055 135.6405018 0.0002674355 1.723989e-10 2.921813e-09 10 92508728 92508890 163 - 2.109 1.913 -0.655
ENSG00000119912 E056 99.9030683 0.0002934306 1.491314e-04 7.433109e-04 10 92510050 92510132 83 - 1.961 1.849 -0.379
ENSG00000119912 E057 72.5199762 0.0004026190 2.671745e-06 2.022513e-05 10 92510133 92510162 30 - 1.840 1.643 -0.665
ENSG00000119912 E058 110.0945595 0.0065547857 4.896640e-06 3.493199e-05 10 92514920 92515042 123 - 2.024 1.800 -0.752
ENSG00000119912 E059 115.8673864 0.0002968158 4.658440e-15 1.610158e-13 10 92531748 92531917 170 - 2.055 1.763 -0.984
ENSG00000119912 E060 122.1670182 0.0218096051 4.107007e-05 2.361264e-04 10 92534578 92534785 208 - 2.080 1.777 -1.016
ENSG00000119912 E061 106.2306337 0.0035400491 7.198221e-11 1.300726e-09 10 92537366 92537550 185 - 2.021 1.713 -1.038
ENSG00000119912 E062 0.1472490 0.0442260810 1.000000e+00   10 92541298 92541353 56 - 0.067 0.000 -10.944
ENSG00000119912 E063 0.0000000       10 92554722 92554769 48 -      
ENSG00000119912 E064 0.2966881 0.0270642961 8.531763e-01   10 92554881 92554917 37 - 0.125 0.000 -11.923
ENSG00000119912 E065 1.5532566 0.0086889618 2.912814e-01 4.321387e-01 10 92555372 92556086 715 - 0.399 0.213 -1.253
ENSG00000119912 E066 0.0000000       10 92558794 92558922 129 -      
ENSG00000119912 E067 7.7607571 0.0948640034 1.488277e-01 2.600843e-01 10 92559034 92559215 182 - 0.923 0.689 -0.922
ENSG00000119912 E068 11.0722783 0.0170589254 7.216319e-01 8.159269e-01 10 92572913 92573197 285 - 1.023 1.021 -0.008
ENSG00000119912 E069 5.4834628 0.0129519286 8.075039e-02 1.607177e-01 10 92573689 92573921 233 - 0.803 0.548 -1.081
ENSG00000119912 E070 57.8429097 0.0127167515 4.919035e-06 3.506270e-05 10 92573922 92574096 175 - 1.765 1.421 -1.176