ENSG00000119906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238961 ENSG00000119906 HEK293_OSMI2_2hA HEK293_TMG_2hB SLF2 protein_coding protein_coding 11.02957 6.202473 16.36831 0.4193012 0.6233496 1.398547 8.1234175 3.564786 13.7283133 0.2320148 0.31172022 1.942276 0.68602500 0.5795333 0.83996667 0.26043333 3.954433e-04 3.783057e-18 FALSE TRUE
ENST00000370269 ENSG00000119906 HEK293_OSMI2_2hA HEK293_TMG_2hB SLF2 protein_coding protein_coding 11.02957 6.202473 16.36831 0.4193012 0.6233496 1.398547 0.5957203 0.000000 0.8809284 0.0000000 0.48342943 6.477238 0.03797917 0.0000000 0.05243333 0.05243333 3.132796e-01 3.783057e-18 FALSE TRUE
ENST00000609386 ENSG00000119906 HEK293_OSMI2_2hA HEK293_TMG_2hB SLF2 protein_coding protein_coding 11.02957 6.202473 16.36831 0.4193012 0.6233496 1.398547 1.6836269 2.459209 0.8283081 0.3912793 0.03316515 -1.558496 0.22531667 0.3928333 0.05063333 -0.34220000 3.783057e-18 3.783057e-18 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119906 E001 0.1472490 0.0441381484 1.000000e+00   10 100912170 100912962 793 + 0.060 0.000 -7.062
ENSG00000119906 E002 5.9065961 0.0029351772 6.678639e-01 7.750086e-01 10 100912963 100912978 16 + 0.723 0.872 0.590
ENSG00000119906 E003 21.5115508 0.0101770097 6.073258e-01 7.273282e-01 10 100912979 100912995 17 + 1.218 1.369 0.529
ENSG00000119906 E004 62.8569154 0.0008693928 8.301921e-05 4.423123e-04 10 100912996 100913250 255 + 1.630 1.929 1.010
ENSG00000119906 E005 33.0043560 0.0241032399 2.569090e-25 2.888466e-23 10 100913251 100913886 636 + 0.892 2.023 3.940
ENSG00000119906 E006 26.3298971 0.0008515423 5.531546e-03 1.736976e-02 10 100915999 100916042 44 + 1.370 1.224 -0.510
ENSG00000119906 E007 157.2461792 0.0006935543 5.045938e-11 9.371938e-10 10 100916570 100917300 731 + 2.128 1.978 -0.503
ENSG00000119906 E008 45.4195695 0.0243519160 3.215677e-01 4.648220e-01 10 100918384 100918441 58 + 1.565 1.576 0.040
ENSG00000119906 E009 23.5205428 0.0601411763 2.809052e-01 4.207648e-01 10 100923975 100923977 3 + 1.298 1.259 -0.139
ENSG00000119906 E010 234.7577141 0.0108938287 3.973915e-07 3.584471e-06 10 100923978 100924972 995 + 2.304 2.126 -0.596
ENSG00000119906 E011 0.0000000       10 100925405 100925481 77 +      
ENSG00000119906 E012 66.8560553 0.0042876061 1.938289e-06 1.512243e-05 10 100925949 100926019 71 + 1.768 1.551 -0.740
ENSG00000119906 E013 1.0758196 0.0219357117 1.986845e-01 3.245402e-01 10 100926020 100926760 741 + 0.202 0.498 1.860
ENSG00000119906 E014 79.7181130 0.0003574675 3.360664e-07 3.077325e-06 10 100929317 100929439 123 + 1.838 1.671 -0.564
ENSG00000119906 E015 70.8973717 0.0004827327 5.076986e-05 2.856685e-04 10 100929830 100929997 168 + 1.783 1.664 -0.403
ENSG00000119906 E016 64.0732898 0.0003667965 6.513532e-05 3.565972e-04 10 100930976 100931078 103 + 1.741 1.614 -0.430
ENSG00000119906 E017 52.5028189 0.0004697615 1.819119e-04 8.861059e-04 10 100937402 100937477 76 + 1.658 1.522 -0.463
ENSG00000119906 E018 72.0025222 0.0003984517 6.867955e-08 7.200009e-07 10 100938595 100938736 142 + 1.801 1.599 -0.684
ENSG00000119906 E019 3.6722268 0.0847715036 7.115794e-01 8.085129e-01 10 100943654 100944025 372 + 0.596 0.588 -0.036
ENSG00000119906 E020 62.5626485 0.0191919156 6.447644e-04 2.697332e-03 10 100944026 100944128 103 + 1.741 1.541 -0.678
ENSG00000119906 E021 79.4823868 0.0003191957 8.146373e-05 4.348933e-04 10 100945330 100945506 177 + 1.825 1.727 -0.332
ENSG00000119906 E022 69.7928706 0.0003742776 6.251947e-05 3.438163e-04 10 100947039 100947136 98 + 1.775 1.657 -0.397
ENSG00000119906 E023 63.9729752 0.0003582113 2.687620e-03 9.337104e-03 10 100947760 100947847 88 + 1.729 1.664 -0.220
ENSG00000119906 E024 92.4173038 0.0003371918 2.631391e-02 6.457789e-02 10 100950076 100950207 132 + 1.872 1.874 0.008
ENSG00000119906 E025 80.5863764 0.0003723399 6.843816e-01 7.873711e-01 10 100950676 100950753 78 + 1.795 1.878 0.282
ENSG00000119906 E026 86.6943499 0.0021212420 9.196058e-01 9.532113e-01 10 100956451 100956537 87 + 1.822 1.929 0.362
ENSG00000119906 E027 75.6647401 0.0003564533 9.516121e-01 9.737015e-01 10 100959428 100959496 69 + 1.766 1.866 0.337
ENSG00000119906 E028 0.4418608 0.0247173184 5.732353e-01 6.992049e-01 10 100959497 100959590 94 + 0.159 0.000 -8.639
ENSG00000119906 E029 771.0108593 0.0084304635 2.830230e-13 7.546497e-12 10 100961877 100965134 3258 + 2.700 3.035 1.115