ENSG00000119866

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358510 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.2404050 0.1522941 0.6456454 0.07948745 0.09442000 2.0143053 0.03940417 0.01916667 0.11436667 0.09520000 0.0066731308 0.0003244053 FALSE  
ENST00000489516 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.6870967 1.3069708 0.4824649 0.21319300 0.19299989 -1.4191307 0.09809583 0.15880000 0.09440000 -0.06440000 0.5261901953 0.0003244053 FALSE  
ENST00000642384 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.8419288 1.0512637 0.5841870 0.02564047 0.09793542 -0.8367942 0.12658333 0.12503333 0.10966667 -0.01536667 0.8153793167 0.0003244053 FALSE  
ENST00000642439 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.3323588 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.05071250 0.00000000 0.00000000 0.00000000   0.0003244053 FALSE  
ENST00000643222 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.5845566 0.5547720 1.3952006 0.55477200 0.10075365 1.3150357 0.09763333 0.05713333 0.25063333 0.19350000 0.1068167277 0.0003244053 FALSE  
ENST00000643459 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.8241956 0.8986948 0.6427003 0.45582650 0.32140488 -0.4773751 0.11944167 0.10630000 0.10590000 -0.00040000 1.0000000000 0.0003244053 FALSE  
ENST00000643716 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding protein_coding 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.2909320 0.1446473 0.4083249 0.02229758 0.02258430 1.4356418 0.04793333 0.01690000 0.07386667 0.05696667 0.0003244053 0.0003244053 FALSE  
ENST00000645405 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding processed_transcript 6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 0.4238456 1.1040396 0.5624877 0.61449769 0.49033401 -0.9604837 0.06510417 0.12146667 0.09143333 -0.03003333 0.8904947668 0.0003244053    
MSTRG.18440.6 ENSG00000119866 HEK293_OSMI2_2hA HEK293_TMG_2hB BCL11A protein_coding   6.743066 8.503957 5.591422 0.620025 0.5172846 -0.6040369 1.3777898 1.9989390 0.2361054 0.53115114 0.23610537 -3.0290857 0.18886250 0.24430000 0.04060000 -0.20370000 0.1103019669 0.0003244053 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119866 E001 0.0000000       2 60450520 60451145 626 -      
ENSG00000119866 E002 0.0000000       2 60451146 60451166 21 -      
ENSG00000119866 E003 0.0000000       2 60451167 60451780 614 -      
ENSG00000119866 E004 0.0000000       2 60451781 60451889 109 -      
ENSG00000119866 E005 1.2490919 0.1081077407 4.790797e-01 6.174879e-01 2 60451890 60452157 268 - 0.432 0.297 -0.793
ENSG00000119866 E006 0.7373013 0.1742529926 8.077060e-01 8.778166e-01 2 60452158 60452159 2 - 0.268 0.237 -0.232
ENSG00000119866 E007 20.9896538 0.0272045462 5.470577e-03 1.720997e-02 2 60452160 60452313 154 - 1.067 1.405 1.193
ENSG00000119866 E008 27.6021399 0.0362046244 3.966416e-03 1.304898e-02 2 60452314 60452421 108 - 1.167 1.518 1.225
ENSG00000119866 E009 29.3999371 0.0034979562 3.646595e-02 8.447098e-02 2 60452422 60452499 78 - 1.341 1.505 0.567
ENSG00000119866 E010 23.0686344 0.0008399596 4.488291e-01 5.900717e-01 2 60452500 60452519 20 - 1.305 1.373 0.235
ENSG00000119866 E011 49.9113274 0.0007461666 1.365680e-01 2.432828e-01 2 60452520 60452648 129 - 1.614 1.703 0.302
ENSG00000119866 E012 30.2287085 0.0007936919 3.732653e-02 8.608539e-02 2 60452649 60452666 18 - 1.357 1.509 0.524
ENSG00000119866 E013 1.3327513 0.0423094016 5.276260e-01 6.606598e-01 2 60452955 60453081 127 - 0.268 0.395 0.798
ENSG00000119866 E014 23.1962504 0.0114846542 1.277616e-05 8.280833e-05 2 60457194 60457678 485 - 1.016 1.461 1.574
ENSG00000119866 E015 54.7535542 0.0062767163 1.416101e-01 2.502365e-01 2 60457679 60459819 2141 - 1.652 1.754 0.343
ENSG00000119866 E016 8.9053415 0.0552198147 6.105635e-03 1.888665e-02 2 60459820 60460401 582 - 1.190 0.784 -1.511
ENSG00000119866 E017 3.6638313 0.0570027056 7.856177e-03 2.342008e-02 2 60460402 60460529 128 - 0.893 0.439 -1.961
ENSG00000119866 E018 6.4110092 0.0026527832 2.632021e-04 1.229693e-03 2 60460530 60460681 152 - 1.082 0.651 -1.674
ENSG00000119866 E019 65.6041976 0.0062348906 3.914446e-01 5.353557e-01 2 60460682 60461744 1063 - 1.813 1.778 -0.118
ENSG00000119866 E020 11.2717104 0.0015472050 6.602127e-01 7.689042e-01 2 60461745 60461903 159 - 1.082 1.048 -0.124
ENSG00000119866 E021 6.0203521 0.0028472762 1.250937e-01 2.272683e-01 2 60461904 60461908 5 - 0.938 0.757 -0.704
ENSG00000119866 E022 21.3344181 0.0016909194 6.583937e-03 2.014552e-02 2 60461909 60462281 373 - 1.439 1.246 -0.669
ENSG00000119866 E023 56.0750205 0.0013367385 4.403240e-01 5.820010e-01 2 60462282 60462424 143 - 1.696 1.745 0.167
ENSG00000119866 E024 17.3478531 0.0169723992 2.486987e-01 3.843881e-01 2 60468732 60468739 8 - 1.140 1.272 0.470
ENSG00000119866 E025 31.1705030 0.0444499703 1.444539e-01 2.540839e-01 2 60468740 60468833 94 - 1.340 1.531 0.658
ENSG00000119866 E026 0.0000000       2 60478164 60478239 76 -      
ENSG00000119866 E027 0.2965864 0.2049942756 4.644080e-01   2 60484003 60484465 463 - 0.000 0.172 11.354
ENSG00000119866 E028 0.0000000       2 60508606 60508824 219 -      
ENSG00000119866 E029 3.2846109 0.0446543981 6.710571e-02 1.385474e-01 2 60522081 60522883 803 - 0.358 0.713 1.701
ENSG00000119866 E030 0.1817044 0.0393347096 8.163310e-01   2 60524489 60527654 3166 - 0.000 0.096 10.844
ENSG00000119866 E031 0.0000000       2 60527655 60527794 140 -      
ENSG00000119866 E032 0.0000000       2 60527795 60528215 421 -      
ENSG00000119866 E033 0.0000000       2 60528449 60528535 87 -      
ENSG00000119866 E034 1.8779556 0.0077022429 3.469012e-02 8.105699e-02 2 60532860 60536138 3279 - 0.645 0.299 -1.781
ENSG00000119866 E035 2.4379192 0.0063106071 1.827359e-02 4.772766e-02 2 60536139 60538549 2411 - 0.722 0.351 -1.780
ENSG00000119866 E036 0.1472490 0.0429311236 2.823261e-01   2 60541783 60541840 58 - 0.154 0.000 -12.894
ENSG00000119866 E037 0.1472490 0.0429311236 2.823261e-01   2 60541841 60541843 3 - 0.154 0.000 -12.894
ENSG00000119866 E038 0.7738329 0.0405774421 4.538429e-01 5.945507e-01 2 60541844 60541920 77 - 0.154 0.298 1.210
ENSG00000119866 E039 0.4481018 0.0789897914 9.576847e-01 9.774694e-01 2 60541921 60541925 5 - 0.154 0.174 0.205
ENSG00000119866 E040 17.8693440 0.0011162945 1.075134e-09 1.584942e-08 2 60541926 60544229 2304 - 1.501 1.029 -1.665
ENSG00000119866 E041 1.1770738 0.0109047214 2.884660e-03 9.924278e-03 2 60544230 60544391 162 - 0.601 0.096 -3.589
ENSG00000119866 E042 9.1784551 0.0018984516 1.265899e-11 2.592376e-10 2 60544392 60545917 1526 - 1.323 0.600 -2.751
ENSG00000119866 E043 1.9563045 0.0074938461 1.243597e-01 2.262059e-01 2 60545918 60545970 53 - 0.601 0.351 -1.266
ENSG00000119866 E044 78.5143454 0.0010461309 6.150519e-01 7.333958e-01 2 60545971 60546300 330 - 1.874 1.864 -0.033
ENSG00000119866 E045 0.0000000       2 60546301 60546394 94 -      
ENSG00000119866 E046 0.0000000       2 60549775 60549913 139 -      
ENSG00000119866 E047 2.7010798 0.0165226549 2.783000e-01 4.179663e-01 2 60550868 60550925 58 - 0.645 0.476 -0.779
ENSG00000119866 E048 18.6884180 0.0010242384 6.126326e-02 1.287683e-01 2 60553216 60553393 178 - 1.357 1.221 -0.477
ENSG00000119866 E049 12.9450604 0.0013739750 8.884200e-02 1.733459e-01 2 60553394 60553658 265 - 1.214 1.067 -0.525
ENSG00000119866 E050 3.7140519 0.1135970859 2.077495e-01 3.357786e-01 2 60553878 60554467 590 - 0.786 0.549 -1.007
ENSG00000119866 E051 0.1817044 0.0393347096 8.163310e-01   2 60554840 60554887 48 - 0.000 0.096 10.844