ENSG00000119844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238856 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding protein_coding 6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 1.5395493 0.0000000 3.27614494 0.0000000 0.05375406 8.360252 0.18216250 0.00000000 0.37436667 0.37436667 8.596352e-25 8.596352e-25 FALSE TRUE
ENST00000409183 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding protein_coding 6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 0.4805569 0.6896241 0.29058816 0.1023584 0.29058816 -1.218792 0.12221250 0.22783333 0.03173333 -0.19610000 6.064073e-02 8.596352e-25 FALSE TRUE
ENST00000695960 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding nonsense_mediated_decay 6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 0.7566498 0.2056924 0.93339423 0.2056924 0.39241611 2.128885 0.11814583 0.05860000 0.10430000 0.04570000 5.198715e-01 8.596352e-25 TRUE TRUE
MSTRG.18522.10 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding   6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 2.2009991 0.8076166 3.40156160 0.4069661 0.19319052 2.060936 0.33214583 0.30153333 0.38896667 0.08743333 8.248031e-01 8.596352e-25 FALSE TRUE
MSTRG.18522.12 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding   6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 0.1259592 0.2606427 0.18545881 0.1630133 0.10449825 -0.469525 0.02703333 0.08463333 0.02176667 -0.06286667 6.810374e-01 8.596352e-25 FALSE TRUE
MSTRG.18522.15 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding   6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 0.2407434 0.5279420 0.00000000 0.5279420 0.00000000 -5.749379 0.06630833 0.15043333 0.00000000 -0.15043333 6.197159e-01 8.596352e-25 FALSE TRUE
MSTRG.18522.4 ENSG00000119844 HEK293_OSMI2_2hA HEK293_TMG_2hB AFTPH protein_coding   6.051112 3.017968 8.768654 0.3460809 0.221627 1.53565 0.2183339 0.4926509 0.02539486 0.3552072 0.02539486 -3.827945 0.06818750 0.16530000 0.00290000 -0.16240000 2.413031e-01 8.596352e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119844 E001 0.0000000       2 64524299 64524304 6 +      
ENSG00000119844 E002 0.0000000       2 64524305 64524327 23 +      
ENSG00000119844 E003 0.0000000       2 64524328 64524354 27 +      
ENSG00000119844 E004 0.0000000       2 64524355 64524374 20 +      
ENSG00000119844 E005 0.4439371 0.0215706438 5.823844e-01 7.067470e-01 2 64524375 64524399 25 + 0.166 0.000 -9.997
ENSG00000119844 E006 0.8878743 0.0131289495 2.017137e-01 3.283163e-01 2 64524400 64524411 12 + 0.286 0.000 -10.994
ENSG00000119844 E007 14.6457707 0.0236855348 3.290737e-01 4.725710e-01 2 64524412 64524526 115 + 1.128 1.052 -0.273
ENSG00000119844 E008 19.2207499 0.0146958820 4.404943e-02 9.847576e-02 2 64524527 64524612 86 + 1.257 1.077 -0.644
ENSG00000119844 E009 27.0014042 0.0007802568 1.564087e-07 1.530456e-06 2 64551443 64551568 126 + 1.433 0.963 -1.675
ENSG00000119844 E010 125.0009907 0.0201322434 1.572119e-04 7.793417e-04 2 64551569 64552511 943 + 2.055 1.829 -0.762
ENSG00000119844 E011 75.3583538 0.0003911109 1.600530e-04 7.920375e-04 2 64552512 64552875 364 + 1.823 1.688 -0.459
ENSG00000119844 E012 73.7534134 0.0003788841 2.420289e-03 8.522928e-03 2 64552876 64553152 277 + 1.808 1.711 -0.326
ENSG00000119844 E013 56.7437766 0.0043973020 8.045726e-01 8.756519e-01 2 64553153 64553409 257 + 1.668 1.707 0.132
ENSG00000119844 E014 49.6199892 0.0069201343 9.734645e-01 9.874225e-01 2 64567562 64567713 152 + 1.607 1.658 0.171
ENSG00000119844 E015 46.2558247 0.0005606636 9.175204e-01 9.518842e-01 2 64569092 64569218 127 + 1.580 1.629 0.169
ENSG00000119844 E016 1.4864473 0.0087211876 3.712855e-01 5.157191e-01 2 64569219 64569622 404 + 0.380 0.226 -1.038
ENSG00000119844 E017 26.5473452 0.0007259695 7.727800e-01 8.533331e-01 2 64569623 64569679 57 + 1.351 1.383 0.112
ENSG00000119844 E018 38.4315815 0.0006435760 1.554352e-01 2.689788e-01 2 64572946 64573068 123 + 1.523 1.481 -0.141
ENSG00000119844 E019 0.4375944 0.0272208238 5.841251e-01 7.081200e-01 2 64573069 64573405 337 + 0.166 0.000 -9.994
ENSG00000119844 E020 24.4237835 0.0008143450 4.199033e-01 5.631618e-01 2 64579486 64579546 61 + 1.330 1.317 -0.043
ENSG00000119844 E021 6.4100589 0.0028967171 1.391590e-01 2.469047e-01 2 64579547 64581099 1553 + 0.829 0.644 -0.754
ENSG00000119844 E022 1.2178718 0.0104569068 7.688376e-01 8.506037e-01 2 64581100 64581189 90 + 0.286 0.373 0.547
ENSG00000119844 E023 2.7837122 0.0069719251 4.792491e-01 6.176348e-01 2 64581190 64581273 84 + 0.480 0.644 0.753
ENSG00000119844 E024 46.5441858 0.0064364368 1.106159e-01 2.064396e-01 2 64585422 64585545 124 + 1.554 1.721 0.568
ENSG00000119844 E025 16.8945980 0.0061316150 2.205408e-01 3.510548e-01 2 64591885 64591887 3 + 1.128 1.303 0.617
ENSG00000119844 E026 166.1140020 0.0162265060 1.973907e-10 3.309591e-09 2 64591888 64593005 1118 + 2.013 2.422 1.368