ENSG00000119801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261353 ENSG00000119801 HEK293_OSMI2_2hA HEK293_TMG_2hB YPEL5 protein_coding protein_coding 9.059447 7.934726 12.70653 0.7612752 0.418915 0.6786355 6.3842793 6.4141676 8.421820 0.7114925 0.2732621 0.3923345 0.7039958 0.80623333 0.6644667 -0.14176667 0.0191046 0.0191046 FALSE FALSE
ENST00000379519 ENSG00000119801 HEK293_OSMI2_2hA HEK293_TMG_2hB YPEL5 protein_coding protein_coding 9.059447 7.934726 12.70653 0.7612752 0.418915 0.6786355 1.1691808 0.4833408 2.039461 0.2026037 0.3871217 2.0545882 0.1187875 0.05783333 0.1594000 0.10156667 0.1266965 0.0191046 FALSE FALSE
MSTRG.18156.1 ENSG00000119801 HEK293_OSMI2_2hA HEK293_TMG_2hB YPEL5 protein_coding   9.059447 7.934726 12.70653 0.7612752 0.418915 0.6786355 0.9741451 0.6409431 1.866324 0.3516039 0.5176834 1.5273059 0.1122000 0.08266667 0.1460000 0.06333333 0.6515956 0.0191046 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119801 E001 0.2934659 0.0283091630 7.821348e-01   2 30146880 30146940 61 + 0.098 0.151 0.712
ENSG00000119801 E002 1.3244365 0.0350790689 6.045192e-02 0.1273879817 2 30146941 30146962 22 + 0.482 0.151 -2.288
ENSG00000119801 E003 18.1390890 0.0231578437 5.742910e-01 0.7001381976 2 30146963 30147006 44 + 1.290 1.266 -0.086
ENSG00000119801 E004 49.4019053 0.0005025386 1.244780e-01 0.2263601777 2 30147007 30147062 56 + 1.710 1.682 -0.095
ENSG00000119801 E005 0.4470576 0.0229030425 8.146329e-01 0.8825693807 2 30147516 30147560 45 + 0.178 0.151 -0.288
ENSG00000119801 E006 0.4470576 0.0229030425 8.146329e-01 0.8825693807 2 30147561 30147951 391 + 0.178 0.151 -0.288
ENSG00000119801 E007 0.1472490 0.0430777363 7.088270e-01   2 30147952 30147956 5 + 0.098 0.000 -8.718
ENSG00000119801 E008 0.2924217 0.0290785164 3.350011e-01   2 30147957 30147965 9 + 0.178 0.000 -9.811
ENSG00000119801 E009 0.4772466 0.0221044365 3.687889e-01 0.5132032089 2 30147966 30148091 126 + 0.098 0.263 1.713
ENSG00000119801 E010 11.1103321 0.0015721700 7.819518e-03 0.0233274168 2 30148245 30148305 61 + 1.160 0.930 -0.843
ENSG00000119801 E011 15.7805498 0.0011467935 9.856313e-05 0.0005151316 2 30148306 30148463 158 + 1.329 1.025 -1.084
ENSG00000119801 E012 10.0618860 0.0029348258 1.300564e-02 0.0359249877 2 30148464 30148541 78 + 1.129 0.907 -0.815
ENSG00000119801 E013 0.5483223 0.0220494372 3.640231e-01 0.5084281509 2 30155815 30155849 35 + 0.098 0.264 1.718
ENSG00000119801 E014 1.7295487 0.0246595132 3.824115e-01 0.5266286253 2 30155850 30155910 61 + 0.482 0.352 -0.699
ENSG00000119801 E015 1.1395084 0.0117694300 5.183182e-01 0.6525810413 2 30156378 30156627 250 + 0.356 0.264 -0.606
ENSG00000119801 E016 116.2175135 0.0133507560 2.993648e-01 0.4408718701 2 30156628 30156792 165 + 2.072 2.051 -0.070
ENSG00000119801 E017 494.9971237 0.0053711152 7.399863e-04 0.0030427347 2 30158619 30160533 1915 + 2.650 2.743 0.310