ENSG00000119787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378954 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding protein_coding 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 12.107427 4.8789873 17.844769 0.58556030 0.3444036 1.868702 0.39206667 0.6598333 0.21090000 -0.44893333 5.001737e-29 1.360774e-29 FALSE TRUE
ENST00000405384 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding nonsense_mediated_decay 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 2.773601 0.0000000 5.511924 0.00000000 0.6842276 9.109027 0.03232500 0.0000000 0.06506667 0.06506667 2.042830e-10 1.360774e-29 FALSE TRUE
ENST00000406122 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding protein_coding 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 4.489666 1.1178653 7.071734 0.05918115 0.2975023 2.650508 0.11677917 0.1548333 0.08350000 -0.07133333 2.164993e-03 1.360774e-29 FALSE TRUE
ENST00000419554 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding protein_coding 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 3.235682 0.0000000 7.119483 0.00000000 0.3231458 9.477654 0.04317917 0.0000000 0.08443333 0.08443333 1.067789e-14 1.360774e-29 FALSE TRUE
ENST00000472097 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding retained_intron 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 10.216212 0.0000000 20.345445 0.00000000 1.7999024 10.991199 0.11760417 0.0000000 0.23940000 0.23940000 1.360774e-29 1.360774e-29 FALSE FALSE
ENST00000477642 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding retained_intron 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 6.602420 0.9424046 11.625689 0.21731353 0.1796670 3.610838 0.13798750 0.1309000 0.13770000 0.00680000 9.072260e-01 1.360774e-29 FALSE TRUE
ENST00000651368 ENSG00000119787 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL2 protein_coding protein_coding 47.32635 7.360201 84.66372 0.6231676 2.559944 3.522138 4.324311 0.0000000 8.758755 0.00000000 1.1059985 9.776228 0.05019583 0.0000000 0.10336667 0.10336667 1.476332e-13 1.360774e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119787 E001 68.7004282 0.0198482674 5.232186e-14 1.549026e-12 2 38293954 38294359 406 - 1.511 2.189 2.286
ENSG00000119787 E002 207.5931694 0.0076429994 1.129418e-19 6.928916e-18 2 38294360 38295153 794 - 2.058 2.550 1.643
ENSG00000119787 E003 224.2275565 0.0093347374 2.957383e-11 5.701305e-10 2 38295154 38295430 277 - 2.121 2.520 1.330
ENSG00000119787 E004 224.4162958 0.0002607579 6.865659e-22 5.394768e-20 2 38295431 38295608 178 - 2.143 2.462 1.064
ENSG00000119787 E005 230.3018184 0.0002293159 7.578412e-08 7.876816e-07 2 38295609 38295900 292 - 2.183 2.385 0.677
ENSG00000119787 E006 66.5340657 0.0003895992 8.740610e-01 9.230270e-01 2 38295901 38295902 2 - 1.682 1.715 0.114
ENSG00000119787 E007 68.3839218 0.0003904141 9.819159e-01 9.926945e-01 2 38295903 38295907 5 - 1.692 1.736 0.150
ENSG00000119787 E008 250.5900621 0.0006074446 7.305168e-01 8.224485e-01 2 38295908 38296113 206 - 2.249 2.303 0.181
ENSG00000119787 E009 61.1363619 0.0004211362 4.500045e-01 5.911821e-01 2 38296114 38296356 243 - 1.640 1.729 0.301
ENSG00000119787 E010 33.7241323 0.0046020125 3.862456e-01 5.304347e-01 2 38296357 38296407 51 - 1.410 1.377 -0.114
ENSG00000119787 E011 40.2158891 0.0006461566 3.349946e-01 4.787402e-01 2 38296408 38296482 75 - 1.482 1.449 -0.111
ENSG00000119787 E012 51.8088033 0.0008682102 1.134056e-01 2.104905e-01 2 38296483 38296590 108 - 1.592 1.522 -0.240
ENSG00000119787 E013 28.3981429 0.0031988625 1.900651e-01 3.138599e-01 2 38296686 38296700 15 - 1.342 1.255 -0.304
ENSG00000119787 E014 43.9051536 0.0005424993 1.288627e-04 6.538812e-04 2 38297931 38298143 213 - 1.543 1.255 -1.000
ENSG00000119787 E015 169.6173761 0.0002046083 1.044016e-01 1.971883e-01 2 38298144 38298217 74 - 2.091 2.072 -0.063
ENSG00000119787 E016 422.4665803 0.0018768527 8.295301e-02 1.641686e-01 2 38298218 38298575 358 - 2.484 2.472 -0.042
ENSG00000119787 E017 137.3940187 0.0002311922 3.272560e-01 4.706991e-01 2 38299256 38299327 72 - 1.999 2.001 0.008
ENSG00000119787 E018 121.2159714 0.0002685137 4.734823e-01 6.124233e-01 2 38300272 38300328 57 - 1.943 1.955 0.039
ENSG00000119787 E019 1.0351233 0.0120295985 3.286128e-01 4.721154e-01 2 38300329 38300433 105 - 0.273 0.000 -10.331
ENSG00000119787 E020 112.0592665 0.0011153586 1.542070e-01 2.673884e-01 2 38309379 38309430 52 - 1.916 1.888 -0.092
ENSG00000119787 E021 151.8811043 0.0002177866 6.438598e-05 3.529027e-04 2 38309431 38309506 76 - 2.058 1.929 -0.432
ENSG00000119787 E022 195.3943514 0.0005521231 1.025889e-05 6.802172e-05 2 38310309 38310447 139 - 2.166 2.036 -0.435
ENSG00000119787 E023 182.3418051 0.0002737476 1.597302e-04 7.906876e-04 2 38313151 38313243 93 - 2.134 2.030 -0.348
ENSG00000119787 E024 114.6097239 0.0002888867 5.524059e-05 3.078623e-04 2 38314608 38314608 1 - 1.941 1.781 -0.540
ENSG00000119787 E025 152.3243493 0.0005303918 2.464096e-04 1.160338e-03 2 38314609 38314654 46 - 2.059 1.942 -0.391
ENSG00000119787 E026 96.8892609 0.0002769822 3.057246e-03 1.043466e-02 2 38314655 38314664 10 - 1.864 1.749 -0.387
ENSG00000119787 E027 120.8257160 0.0002397762 1.548528e-04 7.685521e-04 2 38315284 38315334 51 - 1.962 1.822 -0.472
ENSG00000119787 E028 5.0339030 0.0441850566 8.036259e-01 8.750289e-01 2 38318326 38318534 209 - 0.665 0.643 -0.091
ENSG00000119787 E029 168.0450675 0.0034782941 5.817657e-05 3.224982e-04 2 38318535 38318639 105 - 2.106 1.945 -0.540
ENSG00000119787 E030 0.7342825 0.0162723324 5.404046e-01 6.715559e-01 2 38318835 38318884 50 - 0.211 0.000 -9.846
ENSG00000119787 E031 139.4487189 0.0032317566 2.507664e-06 1.909520e-05 2 38318885 38318936 52 - 2.031 1.811 -0.739
ENSG00000119787 E032 181.0303910 0.0008223190 6.889074e-09 8.752109e-08 2 38318937 38319019 83 - 2.142 1.934 -0.699
ENSG00000119787 E033 116.0433405 0.0011818884 2.180585e-05 1.339989e-04 2 38343268 38343293 26 - 1.947 1.763 -0.623
ENSG00000119787 E034 91.4661580 0.0004396618 1.473011e-05 9.416800e-05 2 38343294 38343296 3 - 1.848 1.638 -0.712
ENSG00000119787 E035 234.8400624 0.0001663234 1.083954e-09 1.597198e-08 2 38343297 38343512 216 - 2.251 2.078 -0.577
ENSG00000119787 E036 3.9355168 0.0065070230 8.429135e-01 9.021383e-01 2 38354067 38354177 111 - 0.573 0.643 0.306
ENSG00000119787 E037 1.3403442 0.0266565539 2.199700e-01 3.503791e-01 2 38358443 38358688 246 - 0.327 0.000 -10.695
ENSG00000119787 E038 0.0000000       2 38359517 38359604 88 -      
ENSG00000119787 E039 1.0361675 0.0117343753 1.000000e+00 1.000000e+00 2 38376116 38376594 479 - 0.243 0.267 0.180
ENSG00000119787 E040 92.0170851 0.0010653235 9.285673e-04 3.714485e-03 2 38377143 38377285 143 - 1.847 1.700 -0.495