ENSG00000119778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238789 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding protein_coding 3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 1.8403029 0.2609673 2.0948870 0.13932121 0.48899943 2.957552 0.47435417 0.27293333 0.49786667 0.22493333 0.59392093 0.01568097 FALSE TRUE
ENST00000381024 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding protein_coding 3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 0.3311592 0.5237641 0.1797954 0.12547928 0.17979544 -1.491757 0.19931250 0.50733333 0.03820000 -0.46913333 0.01568097 0.01568097 FALSE TRUE
ENST00000478885 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding retained_intron 3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 0.2285751 0.1035948 0.3548670 0.03645099 0.03220698 1.683474 0.06902917 0.09926667 0.08486667 -0.01440000 0.88488114 0.01568097   FALSE
ENST00000486610 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding retained_intron 3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 0.2321360 0.0000000 0.2051733 0.00000000 0.04928391 4.427427 0.06850000 0.00000000 0.04866667 0.04866667 0.08456024 0.01568097   FALSE
MSTRG.18035.2 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding   3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 0.2472707 0.0903159 0.8449391 0.09031590 0.52909399 3.091271 0.09532917 0.08106667 0.21630000 0.13523333 0.74918378 0.01568097 FALSE TRUE
MSTRG.18035.4 ENSG00000119778 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD2B protein_coding   3.258157 1.015181 4.173182 0.05406891 0.2670664 2.028722 0.1800717 0.0000000 0.3183476 0.00000000 0.08814977 5.037152 0.03522917 0.00000000 0.07436667 0.07436667 0.01745681 0.01568097 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119778 E001 0.1482932 0.0413173768 9.140960e-02   2 23748664 23748670 7 - 0.000 0.236 11.430
ENSG00000119778 E002 134.3312501 0.0122583909 6.493344e-08 6.839836e-07 2 23748671 23751302 2632 - 1.948 2.274 1.090
ENSG00000119778 E003 31.5885577 0.0024519229 4.654814e-01 6.051900e-01 2 23751303 23751802 500 - 1.392 1.488 0.331
ENSG00000119778 E004 15.9875240 0.0011754064 9.434125e-01 9.685087e-01 2 23751803 23751906 104 - 1.123 1.170 0.168
ENSG00000119778 E005 21.8023517 0.0009006728 2.388870e-02 5.957614e-02 2 23751907 23752087 181 - 1.205 1.433 0.795
ENSG00000119778 E006 8.7534444 0.0127652995 2.357070e-01 3.692151e-01 2 23754179 23754183 5 - 0.854 1.047 0.725
ENSG00000119778 E007 16.8635085 0.0181668400 7.749490e-01 8.549838e-01 2 23754184 23754307 124 - 1.142 1.211 0.243
ENSG00000119778 E008 14.2467284 0.0016469174 4.249925e-01 5.679328e-01 2 23754647 23754774 128 - 1.098 1.047 -0.185
ENSG00000119778 E009 0.8942170 0.0133745895 2.600922e-01 3.975659e-01 2 23754775 23755092 318 - 0.273 0.000 -13.518
ENSG00000119778 E010 24.1132727 0.0008032978 1.382661e-01 2.456817e-01 2 23757418 23757687 270 - 1.322 1.229 -0.328
ENSG00000119778 E011 32.9656950 0.0006922366 2.377038e-01 3.714859e-01 2 23757688 23758101 414 - 1.445 1.397 -0.168
ENSG00000119778 E012 15.8452999 0.0012005853 9.760522e-01 9.890412e-01 2 23762209 23762346 138 - 1.132 1.169 0.132
ENSG00000119778 E013 13.2819968 0.0014189121 2.394123e-01 3.734382e-01 2 23765506 23765628 123 - 1.027 1.190 0.589
ENSG00000119778 E014 14.7146084 0.0037360872 6.133876e-01 7.320658e-01 2 23782869 23783028 160 - 1.078 1.170 0.332
ENSG00000119778 E015 3.5158166 0.0045222606 1.606777e-01 2.760038e-01 2 23785755 23786026 272 - 0.523 0.783 1.117
ENSG00000119778 E016 7.1316219 0.0337785746 3.898910e-01 5.339374e-01 2 23786027 23786041 15 - 0.845 0.727 -0.468
ENSG00000119778 E017 18.1458628 0.0122218656 8.895343e-01 9.333801e-01 2 23786042 23786223 182 - 1.177 1.229 0.186
ENSG00000119778 E018 0.0000000       2 23788202 23788511 310 -      
ENSG00000119778 E019 14.5407579 0.0013848968 8.489708e-01 9.062759e-01 2 23788512 23788647 136 - 1.088 1.148 0.214
ENSG00000119778 E020 17.8977976 0.0022892384 3.630795e-01 5.075061e-01 2 23798138 23798323 186 - 1.155 1.282 0.447
ENSG00000119778 E021 0.0000000       2 23799825 23799993 169 -      
ENSG00000119778 E022 0.0000000       2 23806171 23806173 3 -      
ENSG00000119778 E023 0.0000000       2 23806174 23806228 55 -      
ENSG00000119778 E024 0.0000000       2 23808989 23809176 188 -      
ENSG00000119778 E025 20.3154184 0.0010265966 3.767955e-01 5.211087e-01 2 23810316 23810502 187 - 1.209 1.328 0.418
ENSG00000119778 E026 0.1515154 0.0429069018 1.000000e+00   2 23811192 23811470 279 - 0.059 0.000 -11.113
ENSG00000119778 E027 13.8098724 0.0278960898 4.276837e-01 5.705230e-01 2 23819747 23819882 136 - 1.093 1.018 -0.272
ENSG00000119778 E028 18.4778203 0.0193866194 7.234682e-01 8.172976e-01 2 23823258 23823510 253 - 1.197 1.191 -0.021
ENSG00000119778 E029 9.9519013 0.0039791324 5.173911e-01 6.517860e-01 2 23823511 23823569 59 - 0.963 0.916 -0.175
ENSG00000119778 E030 0.8962933 0.1111895151 2.930106e-01 4.340515e-01 2 23827798 23827860 63 - 0.274 0.000 -13.573
ENSG00000119778 E031 10.8869164 0.0016498672 5.126907e-01 6.475915e-01 2 23828849 23828939 91 - 0.996 0.953 -0.160
ENSG00000119778 E032 0.0000000       2 23832208 23832611 404 -      
ENSG00000119778 E033 13.0081638 0.0061720686 5.022038e-01 6.382689e-01 2 23833919 23834078 160 - 1.061 1.018 -0.157
ENSG00000119778 E034 0.1472490 0.0438502680 1.000000e+00   2 23856009 23856442 434 - 0.059 0.000 -11.113
ENSG00000119778 E035 9.2179334 0.0130622731 5.551099e-01 6.840018e-01 2 23857415 23857503 89 - 0.927 0.877 -0.188
ENSG00000119778 E036 13.8608783 0.0259903747 3.328113e-01 4.764972e-01 2 23863381 23863555 175 - 1.093 0.990 -0.375
ENSG00000119778 E037 13.8954864 0.0012760611 1.985084e-01 3.243309e-01 2 23864809 23864924 116 - 1.098 0.987 -0.407
ENSG00000119778 E038 16.3108446 0.0409989194 2.255887e-01 3.571097e-01 2 23867835 23867946 112 - 1.165 1.022 -0.515
ENSG00000119778 E039 9.6508622 0.0566494228 1.440938e-01 2.535800e-01 2 23869663 23869669 7 - 0.971 0.732 -0.927
ENSG00000119778 E040 15.9640511 0.0012699094 4.644387e-03 1.494336e-02 2 23869670 23869761 92 - 1.181 0.876 -1.119
ENSG00000119778 E041 16.7278901 0.0024346834 6.995537e-03 2.121200e-02 2 23875829 23875904 76 - 1.197 0.916 -1.025
ENSG00000119778 E042 20.3574565 0.0194979452 1.166413e-02 3.273293e-02 2 23880639 23880755 117 - 1.274 0.989 -1.023
ENSG00000119778 E043 0.1515154 0.0429069018 1.000000e+00   2 23883594 23883635 42 - 0.059 0.000 -11.113
ENSG00000119778 E044 17.7915571 0.0012184428 9.336122e-05 4.907876e-04 2 23884765 23884873 109 - 1.236 0.784 -1.675
ENSG00000119778 E045 12.7965902 0.0118617197 5.011780e-04 2.164323e-03 2 23885727 23885829 103 - 1.108 0.592 -2.024
ENSG00000119778 E046 14.3493553 0.0104531997 2.972865e-02 7.142591e-02 2 23887832 23887985 154 - 1.128 0.877 -0.926
ENSG00000119778 E047 9.6027038 0.0034023008 1.871942e-02 4.872012e-02 2 23888350 23888399 50 - 0.983 0.665 -1.250
ENSG00000119778 E048 13.1170724 0.0014519378 4.248649e-02 9.560444e-02 2 23895819 23895970 152 - 1.093 0.876 -0.804
ENSG00000119778 E049 12.5804165 0.0013862149 2.611733e-02 6.418193e-02 2 23926555 23927123 569 - 1.083 0.832 -0.937