ENSG00000119777

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238788 ENSG00000119777 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM214 protein_coding protein_coding 55.46912 61.86658 41.39869 2.969917 1.763422 -0.57946 36.478203 47.028962 23.536281 2.3303283 0.8558079 -0.998357 0.64984167 0.7601 0.57000000 -0.19010000 6.654788e-07 1.168616e-07 FALSE TRUE
ENST00000460904 ENSG00000119777 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM214 protein_coding retained_intron 55.46912 61.86658 41.39869 2.969917 1.763422 -0.57946 2.936990 1.415112 3.582013 0.3523129 0.1906086 1.333717 0.05515000 0.0229 0.08646667 0.06356667 1.687974e-05 1.168616e-07 FALSE TRUE
ENST00000475258 ENSG00000119777 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM214 protein_coding retained_intron 55.46912 61.86658 41.39869 2.969917 1.763422 -0.57946 2.937937 1.235142 2.712538 0.1091519 0.2082771 1.128642 0.05440417 0.0202 0.06553333 0.04533333 1.168616e-07 1.168616e-07 FALSE TRUE
ENST00000495312 ENSG00000119777 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM214 protein_coding retained_intron 55.46912 61.86658 41.39869 2.969917 1.763422 -0.57946 3.506385 1.230724 3.433714 0.4800857 0.3887721 1.472784 0.06555833 0.0194 0.08276667 0.06336667 2.329008e-03 1.168616e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119777 E001 0.9911135 0.0130921814 4.198156e-01 5.630641e-01 2 27032910 27032953 44 + 0.369 0.233 -0.915
ENSG00000119777 E002 2.1359325 0.0068201355 1.433923e-01 2.526294e-01 2 27032954 27032964 11 + 0.616 0.384 -1.137
ENSG00000119777 E003 4.4578212 0.0037541383 1.989825e-01 3.249402e-01 2 27032965 27032976 12 + 0.804 0.636 -0.691
ENSG00000119777 E004 134.6864445 0.0056462175 1.088607e-04 5.628485e-04 2 27032977 27033137 161 + 2.199 2.036 -0.547
ENSG00000119777 E005 140.0787466 0.0041720699 6.185719e-03 1.910319e-02 2 27033138 27033166 29 + 2.177 2.077 -0.333
ENSG00000119777 E006 328.4020984 0.0048810225 7.529556e-02 1.519977e-01 2 27034067 27034266 200 + 2.512 2.465 -0.157
ENSG00000119777 E007 3.4195590 0.0060877764 5.555725e-06 3.913716e-05 2 27034267 27034609 343 + 0.956 0.290 -3.084
ENSG00000119777 E008 331.2250599 0.0021401261 1.784720e-01 2.992361e-01 2 27035135 27035285 151 + 2.497 2.477 -0.067
ENSG00000119777 E009 27.8431396 0.0082251753 3.937340e-14 1.185690e-12 2 27035286 27035481 196 + 1.734 1.162 -1.977
ENSG00000119777 E010 20.7274512 0.0017912337 1.538624e-08 1.831643e-07 2 27035520 27035593 74 + 1.549 1.139 -1.429
ENSG00000119777 E011 319.8887827 0.0064942265 1.837278e-01 3.058853e-01 2 27035594 27035728 135 + 2.495 2.458 -0.123
ENSG00000119777 E012 20.3118259 0.0063059203 1.015367e-06 8.409840e-06 2 27035729 27035969 241 + 1.527 1.139 -1.353
ENSG00000119777 E013 305.0578974 0.0041427020 6.270009e-02 1.312002e-01 2 27035970 27036052 83 + 2.481 2.433 -0.162
ENSG00000119777 E014 183.2573473 0.0021401490 4.241483e-02 9.547267e-02 2 27036487 27036490 4 + 2.262 2.210 -0.174
ENSG00000119777 E015 238.8516762 0.0033539087 9.872182e-02 1.885357e-01 2 27036491 27036525 35 + 2.370 2.330 -0.134
ENSG00000119777 E016 264.2443015 0.0009431327 2.200355e-03 7.842910e-03 2 27036526 27036592 67 + 2.429 2.365 -0.211
ENSG00000119777 E017 299.1055691 0.0002453081 4.505136e-03 1.455713e-02 2 27036705 27036786 82 + 2.472 2.426 -0.152
ENSG00000119777 E018 372.9865643 0.0001414280 1.266758e-04 6.441991e-04 2 27037077 27037178 102 + 2.574 2.516 -0.190
ENSG00000119777 E019 384.9640938 0.0001363146 1.976391e-02 5.098678e-02 2 27037561 27037702 142 + 2.567 2.540 -0.091
ENSG00000119777 E020 13.1816032 0.0015330132 4.090577e-10 6.512711e-09 2 27037703 27037789 87 + 1.415 0.855 -2.021
ENSG00000119777 E021 12.7081279 0.0391885753 6.780299e-05 3.695467e-04 2 27037790 27037814 25 + 1.376 0.876 -1.804
ENSG00000119777 E022 18.7734214 0.0017638841 1.697837e-10 2.881138e-09 2 27037815 27037874 60 + 1.532 1.040 -1.731
ENSG00000119777 E023 13.2677885 0.0328472337 1.397632e-04 7.025503e-04 2 27037875 27037892 18 + 1.376 0.915 -1.656
ENSG00000119777 E024 23.0277988 0.0049864481 3.154347e-05 1.867092e-04 2 27038032 27038145 114 + 1.527 1.217 -1.076
ENSG00000119777 E025 260.9164022 0.0001788702 1.543893e-01 2.676104e-01 2 27038146 27038237 92 + 2.391 2.375 -0.054
ENSG00000119777 E026 182.3289645 0.0010865181 7.428781e-01 8.316945e-01 2 27038484 27038532 49 + 2.220 2.227 0.024
ENSG00000119777 E027 161.2188996 0.0002303980 9.281271e-01 9.587394e-01 2 27038702 27038709 8 + 2.161 2.176 0.049
ENSG00000119777 E028 310.1056437 0.0001992105 5.623451e-02 1.201175e-01 2 27038710 27038815 106 + 2.411 2.471 0.201
ENSG00000119777 E029 290.7196091 0.0001552806 2.769007e-04 1.285704e-03 2 27039047 27039164 118 + 2.354 2.455 0.339
ENSG00000119777 E030 15.1657714 0.0012069637 1.439319e-09 2.071209e-08 2 27039361 27039740 380 + 1.458 0.957 -1.782
ENSG00000119777 E031 277.1569515 0.0001625318 4.137661e-03 1.352813e-02 2 27039741 27039837 97 + 2.344 2.429 0.284
ENSG00000119777 E032 6.5834413 0.0091444270 1.395091e-04 7.014034e-04 2 27039838 27039919 82 + 1.116 0.658 -1.766
ENSG00000119777 E033 6.0245168 0.0034885498 2.380449e-01 3.718687e-01 2 27039920 27040029 110 + 0.911 0.776 -0.524
ENSG00000119777 E034 388.6237690 0.0010059373 2.702554e-05 1.625264e-04 2 27040030 27040198 169 + 2.463 2.585 0.406
ENSG00000119777 E035 3.9056248 0.2115250260 5.011684e-01 6.373293e-01 2 27040199 27040344 146 + 0.774 0.605 -0.709
ENSG00000119777 E036 397.1120897 0.0025563936 4.165271e-02 9.409932e-02 2 27040345 27040496 152 + 2.505 2.585 0.268
ENSG00000119777 E037 575.3246211 0.0005299883 2.938277e-02 7.074203e-02 2 27040711 27040954 244 + 2.682 2.741 0.196
ENSG00000119777 E038 722.9578007 0.0024006662 5.366903e-05 3.000749e-04 2 27040955 27041243 289 + 2.731 2.859 0.423
ENSG00000119777 E039 845.7095118 0.0076213601 1.283049e-05 8.312354e-05 2 27041244 27041694 451 + 2.740 2.945 0.682