ENSG00000119760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337768 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding protein_coding 26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 2.828776 1.734058 4.3492591 0.1269103 0.07528904 1.32163517 0.10647083 0.06066667 0.16130000 0.10063333 3.015800e-11 2.872047e-17 FALSE TRUE
ENST00000405491 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding protein_coding 26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 3.789841 3.862598 4.5448878 0.3888965 0.23787524 0.23411394 0.14227083 0.13520000 0.16853333 0.03333333 4.351098e-01 2.872047e-17 FALSE TRUE
ENST00000406540 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding protein_coding 26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 6.518827 4.303366 7.3940625 0.3173452 0.50105213 0.77950286 0.24919167 0.15016667 0.27396667 0.12380000 1.364542e-04 2.872047e-17 FALSE TRUE
MSTRG.18135.1 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding   26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 2.256105 3.090944 2.4802345 0.5388721 0.38744752 -0.31642579 0.08524167 0.10703333 0.09180000 -0.01523333 8.238460e-01 2.872047e-17 TRUE TRUE
MSTRG.18135.11 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding   26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 2.059848 3.547755 0.4387139 0.4497967 0.27787690 -2.98709920 0.07647917 0.12456667 0.01643333 -0.10813333 7.558445e-02 2.872047e-17 FALSE TRUE
MSTRG.18135.4 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding   26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 4.653649 5.442542 4.5969627 0.2337669 1.01533840 -0.24311313 0.17610000 0.19036667 0.17103333 -0.01933333 8.392927e-01 2.872047e-17 TRUE TRUE
MSTRG.18135.5 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding   26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 2.946162 3.035516 2.9582892 0.5901660 0.49591515 -0.03705509 0.11051250 0.10493333 0.10943333 0.00450000 9.788962e-01 2.872047e-17 TRUE TRUE
MSTRG.18135.8 ENSG00000119760 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT7L protein_coding   26.50675 28.69063 26.96328 1.036625 0.197708 -0.08955106 1.141560 3.554924 0.0000000 0.7744378 0.00000000 -8.47772765 0.04274167 0.12320000 0.00000000 -0.12320000 2.872047e-17 2.872047e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119760 E001 3.249417 0.0047771427 6.017935e-01 7.228642e-01 2 27642618 27642629 12 - 0.667 0.588 -0.345
ENSG00000119760 E002 4.985407 0.0032864234 4.153698e-01 5.587667e-01 2 27642630 27642684 55 - 0.822 0.712 -0.442
ENSG00000119760 E003 5.613021 0.0032399669 4.486985e-01 5.899777e-01 2 27642685 27642722 38 - 0.752 0.849 0.386
ENSG00000119760 E004 13.056268 0.0131086791 3.513665e-01 4.955838e-01 2 27642723 27642892 170 - 1.090 1.186 0.345
ENSG00000119760 E005 14.194402 0.0018669462 1.922922e-01 3.166406e-01 2 27646866 27646993 128 - 1.112 1.229 0.417
ENSG00000119760 E006 8.067988 0.0022268042 2.737724e-04 1.273051e-03 2 27650809 27650811 3 - 1.134 0.712 -1.603
ENSG00000119760 E007 170.745958 0.0002165171 2.891122e-38 8.934983e-36 2 27650812 27653034 2223 - 2.394 2.037 -1.192
ENSG00000119760 E008 13.715963 0.0123866930 6.556185e-04 2.736455e-03 2 27653035 27653051 17 - 1.328 0.968 -1.289
ENSG00000119760 E009 12.388495 0.0250364941 1.659234e-03 6.151649e-03 2 27653052 27653062 11 - 1.293 0.906 -1.401
ENSG00000119760 E010 10.700764 0.0758608006 2.550701e-02 6.292536e-02 2 27653063 27653063 1 - 1.230 0.853 -1.383
ENSG00000119760 E011 11.582306 0.0534149543 2.635062e-02 6.464705e-02 2 27653064 27653069 6 - 1.247 0.909 -1.228
ENSG00000119760 E012 237.787310 0.0038985795 2.228816e-02 5.627275e-02 2 27653070 27653433 364 - 2.330 2.411 0.270
ENSG00000119760 E013 414.979685 0.0001790953 5.932966e-14 1.741799e-12 2 27653434 27653747 314 - 2.540 2.670 0.432
ENSG00000119760 E014 357.905779 0.0002293936 1.036498e-11 2.152377e-10 2 27655365 27655602 238 - 2.475 2.604 0.429
ENSG00000119760 E015 190.205079 0.0003355219 2.212285e-04 1.054738e-03 2 27657345 27657389 45 - 2.222 2.318 0.321
ENSG00000119760 E016 414.954460 0.0001743615 2.389078e-04 1.128687e-03 2 27657390 27657669 280 - 2.580 2.642 0.208
ENSG00000119760 E017 317.057586 0.0001754597 9.214435e-01 9.544167e-01 2 27660984 27661155 172 - 2.503 2.500 -0.009
ENSG00000119760 E018 184.533368 0.0015962882 1.147559e-01 2.124723e-01 2 27661156 27661198 43 - 2.295 2.246 -0.163
ENSG00000119760 E019 302.027358 0.0013858278 3.122245e-02 7.433332e-02 2 27661199 27661388 190 - 2.510 2.456 -0.182
ENSG00000119760 E020 75.811511 0.0003273387 3.802565e-06 2.780871e-05 2 27661389 27661601 213 - 1.977 1.790 -0.631
ENSG00000119760 E021 104.244247 0.0003219460 2.233777e-07 2.121959e-06 2 27661602 27662178 577 - 2.109 1.928 -0.607
ENSG00000119760 E022 205.460126 0.0009962695 2.962110e-01 4.374175e-01 2 27662179 27662281 103 - 2.329 2.299 -0.100
ENSG00000119760 E023 13.638720 0.0016091647 4.942573e-01 6.312099e-01 2 27663324 27663328 5 - 1.134 1.195 0.219
ENSG00000119760 E024 242.849704 0.0011932017 1.341718e-01 2.399483e-01 2 27663329 27663514 186 - 2.407 2.364 -0.142
ENSG00000119760 E025 127.032087 0.0038493293 1.143013e-01 2.118127e-01 2 27663515 27663840 326 - 2.142 2.071 -0.238