ENSG00000119729

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238738 ENSG00000119729 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOQ protein_coding protein_coding 13.30918 7.185485 23.72216 0.2867866 1.30185 1.721679 8.4044599 3.2463050 17.280793 0.73869824 0.5657169 2.408696 0.56459583 0.44850000 0.73070000 0.282200000 0.03170261 0.03170261 FALSE TRUE
ENST00000473428 ENSG00000119729 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOQ protein_coding nonsense_mediated_decay 13.30918 7.185485 23.72216 0.2867866 1.30185 1.721679 2.0133002 2.8505100 1.353581 0.47038535 0.8324339 -1.068872 0.20737500 0.39960000 0.05516667 -0.344433333 0.12406227 0.03170261 FALSE FALSE
ENST00000489448 ENSG00000119729 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOQ protein_coding retained_intron 13.30918 7.185485 23.72216 0.2867866 1.30185 1.721679 0.5412370 0.1874130 0.735292 0.09878933 0.1229857 1.916588 0.05399167 0.02506667 0.03073333 0.005666667 0.82891964 0.03170261   FALSE
ENST00000494370 ENSG00000119729 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOQ protein_coding retained_intron 13.30918 7.185485 23.72216 0.2867866 1.30185 1.721679 0.8607949 0.1896599 1.330681 0.03939191 0.4405835 2.747350 0.06830833 0.02693333 0.05486667 0.027933333 0.38161605 0.03170261 FALSE FALSE
MSTRG.18328.3 ENSG00000119729 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOQ protein_coding   13.30918 7.185485 23.72216 0.2867866 1.30185 1.721679 0.8854230 0.4750130 1.970391 0.25648412 0.2976842 2.029690 0.06423750 0.06676667 0.08463333 0.017866667 0.79982144 0.03170261 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119729 E001 0.1451727 0.0434588454 1.000000e+00   2 46541806 46541960 155 + 0.065 0.000 -9.604
ENSG00000119729 E002 5.3779423 0.0123962614 4.039166e-01 5.476803e-01 2 46542490 46542735 246 + 0.752 0.696 -0.230
ENSG00000119729 E003 26.6862043 0.0017635342 7.407837e-02 1.500521e-01 2 46542736 46543031 296 + 1.376 1.319 -0.201
ENSG00000119729 E004 104.8370041 0.0078853842 4.289190e-02 9.634049e-02 2 46543032 46543148 117 + 1.951 1.926 -0.084
ENSG00000119729 E005 112.4224653 0.0051025594 1.911671e-03 6.952188e-03 2 46543149 46543188 40 + 1.990 1.921 -0.232
ENSG00000119729 E006 1.0447003 0.1132233000 6.082565e-01 7.280466e-01 2 46543400 46543753 354 + 0.293 0.219 -0.556
ENSG00000119729 E007 87.0867254 0.0013473923 1.657087e-04 8.167182e-04 2 46543754 46543766 13 + 1.884 1.791 -0.312
ENSG00000119729 E008 115.9089742 0.0003393935 8.211573e-05 4.379914e-04 2 46543767 46543812 46 + 2.003 1.939 -0.215
ENSG00000119729 E009 0.5546650 0.0215243246 1.110120e-01 2.070316e-01 2 46560524 46560689 166 + 0.065 0.366 3.043
ENSG00000119729 E010 0.1817044 0.0438841742 1.355944e-01   2 46572728 46572786 59 + 0.000 0.220 13.410
ENSG00000119729 E011 108.3416440 0.0003321065 3.452564e-03 1.158891e-02 2 46576087 46576127 41 + 1.967 1.942 -0.085
ENSG00000119729 E012 172.3558914 0.0015420446 3.623460e-03 1.207737e-02 2 46576128 46576251 124 + 2.165 2.153 -0.038
ENSG00000119729 E013 155.5812854 0.0010576833 9.465284e-04 3.776605e-03 2 46576561 46576656 96 + 2.124 2.097 -0.088
ENSG00000119729 E014 12.1266244 0.0390468052 4.012940e-01 5.449941e-01 2 46576657 46577125 469 + 1.059 1.010 -0.181
ENSG00000119729 E015 7.6690945 0.0022934802 2.138706e-01 3.430982e-01 2 46580284 46580556 273 + 0.889 0.798 -0.351
ENSG00000119729 E016 10.0807124 0.0016803734 3.605365e-01 5.048567e-01 2 46580557 46580724 168 + 0.978 0.951 -0.101
ENSG00000119729 E017 1248.2010820 0.0060129122 3.462848e-07 3.163401e-06 2 46580928 46584688 3761 + 2.972 3.152 0.600