ENSG00000119723

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334571 ENSG00000119723 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ6 protein_coding protein_coding 28.01638 35.49382 24.54787 1.343827 1.116358 -0.5317885 12.907308 20.257015 10.075213 1.2193642 0.7579065 -1.0068921 0.4511917 0.57006667 0.4145000 -0.15556667 7.337375e-02 7.037992e-06 FALSE  
ENST00000554320 ENSG00000119723 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ6 protein_coding protein_coding 28.01638 35.49382 24.54787 1.343827 1.116358 -0.5317885 4.462190 7.092432 3.852746 0.3335935 1.6438342 -0.8786864 0.1551167 0.19983333 0.1515000 -0.04833333 6.837756e-01 7.037992e-06 FALSE  
ENST00000556300 ENSG00000119723 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ6 protein_coding retained_intron 28.01638 35.49382 24.54787 1.343827 1.116358 -0.5317885 3.152365 2.334806 3.126143 0.1463437 0.1353398 0.4195231 0.1172292 0.06566667 0.1275667 0.06190000 7.037992e-06 7.037992e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119723 E001 0.3697384 0.0249153409 4.361119e-01 5.782459e-01 14 73949926 73949939 14 + 0.001 0.168 8.393
ENSG00000119723 E002 7.2415585 0.0032961429 1.779635e-02 4.670008e-02 14 73949940 73950180 241 + 1.054 0.775 -1.060
ENSG00000119723 E003 4.0586223 0.0121182789 5.682996e-01 6.949923e-01 14 73950219 73950251 33 + 0.740 0.656 -0.347
ENSG00000119723 E004 8.5925005 0.0571493404 8.336943e-01 8.958389e-01 14 73950252 73950284 33 + 0.979 0.933 -0.173
ENSG00000119723 E005 6.3772622 0.1868999712 9.313245e-01 9.607484e-01 14 73950285 73950288 4 + 0.862 0.817 -0.174
ENSG00000119723 E006 11.0595751 0.0331712073 6.674041e-01 7.746483e-01 14 73950289 73950298 10 + 1.087 1.022 -0.240
ENSG00000119723 E007 12.0495677 0.0188781350 9.503795e-01 9.729511e-01 14 73950299 73950300 2 + 1.087 1.075 -0.045
ENSG00000119723 E008 12.3461541 0.0134914429 9.522835e-01 9.741265e-01 14 73950301 73950301 1 + 1.087 1.091 0.013
ENSG00000119723 E009 16.4914177 0.0021373526 7.669663e-01 8.493220e-01 14 73950302 73950307 6 + 1.187 1.213 0.094
ENSG00000119723 E010 16.4559433 0.0016716811 7.682959e-01 8.502974e-01 14 73950308 73950309 2 + 1.187 1.213 0.094
ENSG00000119723 E011 156.2903362 0.0103432849 9.648754e-01 9.818752e-01 14 73950310 73950495 186 + 2.162 2.158 -0.013
ENSG00000119723 E012 1.0329558 0.0124709344 3.377961e-01 4.816829e-01 14 73950496 73950502 7 + 0.161 0.338 1.393
ENSG00000119723 E013 0.8908930 0.1605461319 4.456656e-01 5.872085e-01 14 73950503 73950523 21 + 0.371 0.228 -0.965
ENSG00000119723 E014 1.8454748 0.0096089603 9.587243e-02 1.841978e-01 14 73950524 73950597 74 + 0.617 0.338 -1.416
ENSG00000119723 E015 103.3673364 0.0057119536 7.514778e-01 8.379147e-01 14 73953435 73953437 3 + 1.971 1.985 0.048
ENSG00000119723 E016 249.5300991 0.0029330094 8.110497e-01 8.801564e-01 14 73953438 73953569 132 + 2.358 2.366 0.024
ENSG00000119723 E017 2.7614472 0.0353012505 6.416062e-02 1.336291e-01 14 73953570 73953812 243 + 0.739 0.424 -1.440
ENSG00000119723 E018 0.4481018 0.0770567197 1.000000e+00 1.000000e+00 14 73955330 73955450 121 + 0.161 0.167 0.058
ENSG00000119723 E019 192.4352670 0.0010804602 2.388054e-01 3.727555e-01 14 73955451 73955509 59 + 2.228 2.264 0.122
ENSG00000119723 E020 4.9060288 0.0032418540 2.009145e-04 9.676779e-04 14 73955510 73955804 295 + 1.018 0.526 -1.999
ENSG00000119723 E021 286.7569754 0.0002138438 8.081934e-01 8.781263e-01 14 73955805 73955928 124 + 2.422 2.428 0.020
ENSG00000119723 E022 10.4154227 0.0121751177 1.091378e-04 5.641273e-04 14 73955929 73956428 500 + 1.278 0.852 -1.556
ENSG00000119723 E023 9.0294798 0.1713575250 6.185315e-03 1.910287e-02 14 73956429 73956790 362 + 1.268 0.748 -1.932
ENSG00000119723 E024 287.7453308 0.0002000516 7.622728e-01 8.458898e-01 14 73958147 73958277 131 + 2.422 2.429 0.024
ENSG00000119723 E025 29.3340992 0.0007140982 5.769069e-08 6.132148e-07 14 73958278 73958491 214 + 1.658 1.313 -1.184
ENSG00000119723 E026 47.7843405 0.0013649251 2.251685e-11 4.428726e-10 14 73958492 73958906 415 + 1.868 1.519 -1.183
ENSG00000119723 E027 20.7146312 0.0009689346 1.846636e-04 8.978307e-04 14 73958907 73958970 64 + 1.480 1.200 -0.974
ENSG00000119723 E028 265.3426973 0.0001934728 7.445393e-01 8.328456e-01 14 73958971 73959078 108 + 2.386 2.394 0.027
ENSG00000119723 E029 9.4033608 0.0229118739 2.937649e-02 7.072871e-02 14 73959079 73959161 83 + 1.147 0.871 -1.018
ENSG00000119723 E030 235.8512169 0.0001875158 9.262850e-01 9.575897e-01 14 73959162 73959224 63 + 2.338 2.341 0.009
ENSG00000119723 E031 2.7355497 0.0056988030 1.230423e-01 2.242963e-01 14 73959225 73959414 190 + 0.703 0.460 -1.099
ENSG00000119723 E032 269.7361403 0.0016371420 2.216415e-01 3.523599e-01 14 73959415 73959498 84 + 2.373 2.408 0.118
ENSG00000119723 E033 162.4397236 0.0002381678 8.071776e-04 3.284096e-03 14 73959499 73959522 24 + 2.106 2.208 0.342
ENSG00000119723 E034 25.5931298 0.0211647033 2.869818e-09 3.909387e-08 14 73959523 73961172 1650 + 1.703 1.122 -2.016
ENSG00000119723 E035 348.4637374 0.0002476765 3.260652e-01 4.695033e-01 14 73961173 73961375 203 + 2.495 2.515 0.068
ENSG00000119723 E036 242.1162709 0.0002171319 4.739617e-01 6.128341e-01 14 73961455 73961570 116 + 2.339 2.357 0.060
ENSG00000119723 E037 265.7436287 0.0021564586 8.257494e-02 1.635727e-01 14 73961737 73961903 167 + 2.353 2.408 0.182
ENSG00000119723 E038 104.2364841 0.0049349895 2.177984e-01 3.477560e-01 14 73962970 73962975 6 + 1.945 2.006 0.206
ENSG00000119723 E039 137.4331154 0.0061541343 2.914505e-01 4.323219e-01 14 73962976 73963670 695 + 2.071 2.121 0.167