ENSG00000119720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354366 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding protein_coding 11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 0.7851939 0.7630634 1.014733 0.06622726 0.02003077 0.4065890 0.06728750 0.08260000 0.06756667 -0.01503333 0.686761592 0.004899942 FALSE TRUE
ENST00000553409 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding nonsense_mediated_decay 11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 3.6887616 3.2583433 4.697097 0.06798036 0.13086356 0.5262779 0.31322500 0.35493333 0.31250000 -0.04243333 0.724698142 0.004899942 FALSE TRUE
ENST00000555903 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding retained_intron 11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 1.3214003 1.0164627 1.635493 0.12118250 0.20561698 0.6808390 0.11338333 0.10833333 0.10943333 0.00110000 1.000000000 0.004899942 FALSE TRUE
ENST00000556189 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding nonsense_mediated_decay 11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 1.3674046 1.4271070 1.158734 0.46424571 0.10423267 -0.2982213 0.11627083 0.14586667 0.07740000 -0.06846667 0.381901885 0.004899942 FALSE TRUE
ENST00000557106 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding processed_transcript 11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 0.6451071 0.4141977 1.223584 0.15216447 0.26324273 1.5400472 0.05234583 0.04223333 0.08080000 0.03856667 0.389078162 0.004899942   FALSE
MSTRG.10050.5 ENSG00000119720 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDE2 protein_coding   11.80719 9.349997 15.02721 0.7709645 0.2769663 0.6839574 3.3576069 1.9762798 4.783501 0.15839755 0.26352993 1.2710110 0.28097083 0.21180000 0.31790000 0.10610000 0.004899942 0.004899942 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119720 E001 223.460188 0.0032377003 7.115771e-02 1.452590e-01 14 90267860 90278053 10194 - 2.320 2.381 0.203
ENSG00000119720 E002 3.147218 0.0917390723 1.937690e-01 3.185131e-01 14 90278054 90278057 4 - 0.475 0.715 1.077
ENSG00000119720 E003 3.591155 0.0510312572 4.389638e-01 5.807492e-01 14 90278058 90278059 2 - 0.583 0.713 0.555
ENSG00000119720 E004 3.921152 0.0218689819 2.275526e-01 3.594690e-01 14 90278060 90278060 1 - 0.583 0.770 0.788
ENSG00000119720 E005 115.757273 0.0009844064 1.297285e-11 2.652349e-10 14 90278061 90278461 401 - 1.941 2.181 0.804
ENSG00000119720 E006 6.176774 0.0211751860 6.242652e-01 7.406485e-01 14 90278462 90278557 96 - 0.823 0.889 0.255
ENSG00000119720 E007 20.250284 0.0009385673 2.530780e-01 3.895439e-01 14 90278558 90279061 504 - 1.281 1.371 0.312
ENSG00000119720 E008 64.548435 0.0054936859 4.984116e-03 1.588616e-02 14 90279062 90279133 72 - 1.734 1.891 0.529
ENSG00000119720 E009 22.612333 0.0041080336 2.237368e-04 1.065153e-03 14 90279134 90281595 2462 - 1.211 1.501 1.007
ENSG00000119720 E010 94.920258 0.0020525195 2.968350e-04 1.367072e-03 14 90286354 90286492 139 - 1.907 2.060 0.512
ENSG00000119720 E011 138.239188 0.0004666837 1.345112e-02 3.696793e-02 14 90288217 90288452 236 - 2.108 2.187 0.263
ENSG00000119720 E012 244.173857 0.0002464885 7.928565e-01 8.675459e-01 14 90288453 90289145 693 - 2.388 2.398 0.032
ENSG00000119720 E013 139.233968 0.0008628360 7.639700e-01 8.471627e-01 14 90290221 90290574 354 - 2.153 2.147 -0.020
ENSG00000119720 E014 47.093278 0.0172222450 9.186965e-01 9.526390e-01 14 90290575 90290607 33 - 1.688 1.678 -0.037
ENSG00000119720 E015 79.162695 0.0119364057 4.307812e-01 5.733912e-01 14 90292697 90292872 176 - 1.926 1.877 -0.166
ENSG00000119720 E016 62.985747 0.0066414451 2.015957e-01 3.281685e-01 14 90298260 90298380 121 - 1.838 1.766 -0.241
ENSG00000119720 E017 62.503569 0.0031446915 5.147896e-02 1.117782e-01 14 90301239 90301372 134 - 1.845 1.747 -0.332
ENSG00000119720 E018 1.857332 0.0088212664 5.285336e-02 1.142283e-01 14 90301774 90301803 30 - 0.583 0.243 -1.915
ENSG00000119720 E019 130.078039 0.0002705225 1.341480e-02 3.687971e-02 14 90302720 90303125 406 - 2.151 2.078 -0.243
ENSG00000119720 E020 45.785195 0.0004806543 2.841191e-01 4.243307e-01 14 90303935 90303953 19 - 1.696 1.644 -0.175
ENSG00000119720 E021 154.243173 0.0002108063 5.567906e-05 3.100324e-04 14 90303954 90304382 429 - 2.241 2.132 -0.367
ENSG00000119720 E022 0.000000       14 90304507 90304654 148 -      
ENSG00000119720 E023 59.634890 0.0004885721 9.555739e-05 5.011505e-04 14 90312394 90312475 82 - 1.862 1.686 -0.595
ENSG00000119720 E024 51.351957 0.0005392953 2.349527e-02 5.876516e-02 14 90312476 90312543 68 - 1.773 1.665 -0.363
ENSG00000119720 E025 31.894672 0.0006798020 5.384980e-01 6.699205e-01 14 90316578 90316586 9 - 1.540 1.506 -0.115
ENSG00000119720 E026 68.710550 0.0076669302 6.688546e-02 1.381945e-01 14 90316587 90316811 225 - 1.894 1.785 -0.367
ENSG00000119720 E027 4.189139 0.0081062785 1.597851e-01 2.748294e-01 14 90317704 90317820 117 - 0.804 0.602 -0.843
ENSG00000119720 E028 49.110483 0.0004947335 8.936363e-04 3.591894e-03 14 90318005 90318113 109 - 1.771 1.606 -0.560
ENSG00000119720 E029 35.779866 0.0005893255 1.782755e-02 4.676898e-02 14 90331841 90331990 150 - 1.626 1.491 -0.463