ENSG00000119715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000509242 ENSG00000119715 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRB protein_coding protein_coding 1.649287 2.749855 0.9798599 0.1919231 0.1200692 -1.479296 0.07906858 0.22477437 0.0000000 0.02427343 0.00000000 -4.5532030 0.04562083 0.08190000 0.0000000 -0.0819000 6.226625e-03 5.219666e-08 FALSE TRUE
ENST00000512784 ENSG00000119715 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRB protein_coding protein_coding 1.649287 2.749855 0.9798599 0.1919231 0.1200692 -1.479296 0.12146283 0.04697236 0.1413007 0.02362126 0.05459227 1.4090843 0.09509167 0.01806667 0.1358667 0.1178000 1.225934e-02 5.219666e-08 FALSE TRUE
ENST00000611036 ENSG00000119715 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRB protein_coding retained_intron 1.649287 2.749855 0.9798599 0.1919231 0.1200692 -1.479296 0.26188787 0.92362445 0.0000000 0.16810164 0.00000000 -6.5447704 0.11030000 0.33353333 0.0000000 -0.3335333 5.219666e-08 5.219666e-08 FALSE FALSE
ENST00000644823 ENSG00000119715 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRB protein_coding protein_coding 1.649287 2.749855 0.9798599 0.1919231 0.1200692 -1.479296 1.07963684 1.48682719 0.8105372 0.15485201 0.04134504 -0.8672671 0.68147083 0.54000000 0.8411333 0.3011333 9.155006e-03 5.219666e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119715 E001 1.3639750 0.0113289431 0.015612325 0.04187135 14 76310712 76310916 205 + 0.620 0.204 -2.398
ENSG00000119715 E002 0.0000000       14 76371347 76371380 34 +      
ENSG00000119715 E003 0.0000000       14 76371381 76371586 206 +      
ENSG00000119715 E004 11.0691075 0.0526117421 0.583168065 0.70735031 14 76376137 76376451 315 + 0.924 1.031 0.396
ENSG00000119715 E005 0.1817044 0.0393837858 1.000000000   14 76404396 76404459 64 + 0.000 0.079 9.038
ENSG00000119715 E006 0.1817044 0.0393837858 1.000000000   14 76407402 76407537 136 + 0.000 0.079 9.038
ENSG00000119715 E007 0.1817044 0.0393837858 1.000000000   14 76407538 76407542 5 + 0.000 0.079 9.038
ENSG00000119715 E008 2.8992817 0.0203292711 0.484014332 0.62203974 14 76407543 76407596 54 + 0.620 0.507 -0.518
ENSG00000119715 E009 15.3843134 0.0013183948 0.884448597 0.93014913 14 76439341 76439641 301 + 1.136 1.154 0.064
ENSG00000119715 E010 6.6255274 0.0560553663 0.440455356 0.58213301 14 76439642 76439750 109 + 0.923 0.801 -0.474
ENSG00000119715 E011 9.8422230 0.0263664596 0.177680137 0.29821608 14 76462545 76462661 117 + 1.100 0.933 -0.615
ENSG00000119715 E012 0.1482932 0.0426945348 1.000000000   14 76463211 76463427 217 + 0.000 0.079 9.026
ENSG00000119715 E013 10.3011108 0.0019236465 0.006230127 0.01921965 14 76482016 76482126 111 + 1.183 0.904 -1.021
ENSG00000119715 E014 13.7425332 0.0014269019 0.174076554 0.29347941 14 76482598 76482759 162 + 1.198 1.073 -0.449
ENSG00000119715 E015 16.6170302 0.0616765990 0.676349583 0.78134753 14 76491447 76491716 270 + 1.137 1.189 0.187
ENSG00000119715 E016 15.5283652 0.0019276098 0.494139271 0.63112293 14 76498214 76498452 239 + 1.101 1.171 0.253
ENSG00000119715 E017 18.2857484 0.0012031437 0.333918794 0.47768208 14 76498453 76498725 273 + 1.278 1.200 -0.274
ENSG00000119715 E018 13.4917639 0.0014143020 0.272963545 0.41193720 14 76498726 76498912 187 + 1.168 1.066 -0.368
ENSG00000119715 E019 35.0395617 0.0006364609 0.019191404 0.04975169 14 76498913 76499645 733 + 1.585 1.449 -0.468
ENSG00000119715 E020 20.9169922 0.0010171928 0.971496215 0.98618740 14 76499646 76499862 217 + 1.265 1.266 0.004
ENSG00000119715 E021 23.0755036 0.0010112702 0.047129022 0.10405515 14 76499863 76500066 204 + 1.168 1.340 0.606
ENSG00000119715 E022 34.0679381 0.0006617714 0.084466860 0.16654864 14 76500067 76500694 628 + 1.375 1.496 0.417
ENSG00000119715 E023 67.8124450 0.0040657916 0.006595907 0.02017558 14 76500695 76501837 1143 + 1.646 1.795 0.504