ENSG00000119711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350259 ENSG00000119711 HEK293_OSMI2_2hA HEK293_TMG_2hB ALDH6A1 protein_coding protein_coding 13.4329 7.645127 23.18104 0.8366877 0.852957 1.599069 4.7672844 1.5520245 10.165882 0.3577968 0.4788019 2.703665 0.30839583 0.1990000 0.4384000 0.23940000 2.337823e-06 2.337823e-06 FALSE TRUE
ENST00000553458 ENSG00000119711 HEK293_OSMI2_2hA HEK293_TMG_2hB ALDH6A1 protein_coding protein_coding 13.4329 7.645127 23.18104 0.8366877 0.852957 1.599069 5.0381563 3.8538098 7.677407 0.6495847 0.1959942 0.992473 0.41477917 0.4985000 0.3315667 -0.16693333 1.235031e-03 2.337823e-06 FALSE TRUE
ENST00000555126 ENSG00000119711 HEK293_OSMI2_2hA HEK293_TMG_2hB ALDH6A1 protein_coding protein_coding 13.4329 7.645127 23.18104 0.8366877 0.852957 1.599069 0.1881662 0.4459153 0.000000 0.2299796 0.0000000 -5.510694 0.02091667 0.0661000 0.0000000 -0.06610000 9.965750e-02 2.337823e-06 FALSE TRUE
MSTRG.9897.2 ENSG00000119711 HEK293_OSMI2_2hA HEK293_TMG_2hB ALDH6A1 protein_coding   13.4329 7.645127 23.18104 0.8366877 0.852957 1.599069 2.8350952 1.6455555 4.408549 0.2582717 0.2518180 1.416257 0.21037083 0.2151333 0.1899000 -0.02523333 7.610776e-01 2.337823e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119711 E001 467.3040422 0.0022402833 1.917646e-10 3.223534e-09 14 74056847 74060246 3400 - 2.586 2.754 0.560
ENSG00000119711 E002 57.1746897 0.0004449657 8.939393e-01 9.361806e-01 14 74060247 74060394 148 - 1.734 1.760 0.088
ENSG00000119711 E003 41.6957407 0.0004942328 3.695667e-01 5.139630e-01 14 74060395 74060414 20 - 1.588 1.658 0.239
ENSG00000119711 E004 207.3621181 0.0002512075 2.091292e-01 3.374894e-01 14 74060415 74060746 332 - 2.282 2.334 0.174
ENSG00000119711 E005 136.2741125 0.0015557278 3.615991e-01 5.059893e-01 14 74064822 74064920 99 - 2.100 2.152 0.173
ENSG00000119711 E006 161.3179094 0.0002392537 3.553709e-02 8.268319e-02 14 74065181 74065360 180 - 2.204 2.163 -0.139
ENSG00000119711 E007 165.4038177 0.0002763598 9.988324e-01 1.000000e+00 14 74066705 74066886 182 - 2.194 2.213 0.066
ENSG00000119711 E008 159.8737385 0.0011644295 5.433661e-01 6.739983e-01 14 74067380 74067569 190 - 2.187 2.184 -0.009
ENSG00000119711 E009 133.3287397 0.0034386971 3.301076e-01 4.737035e-01 14 74068860 74068981 122 - 2.116 2.088 -0.092
ENSG00000119711 E010 0.2965864 0.0456852998 6.140425e-02   14 74068982 74069258 277 - 0.000 0.300 12.597
ENSG00000119711 E011 0.4482035 0.0288930708 3.150571e-01 4.578143e-01 14 74070700 74071194 495 - 0.214 0.000 -10.987
ENSG00000119711 E012 141.5572898 0.0017760925 9.852151e-02 1.882366e-01 14 74071195 74071367 173 - 2.147 2.103 -0.149
ENSG00000119711 E013 95.2398122 0.0033496501 1.269186e-01 2.298586e-01 14 74071368 74071497 130 - 1.982 1.927 -0.182
ENSG00000119711 E014 1.5500475 0.0100371157 4.513533e-01 5.923133e-01 14 74071498 74071569 72 - 0.430 0.301 -0.760
ENSG00000119711 E015 0.8083650 0.1708281516 6.841667e-01 7.871956e-01 14 74071570 74071660 91 - 0.266 0.178 -0.741
ENSG00000119711 E016 1.1854928 0.0186621777 2.339374e-01 3.670624e-01 14 74071878 74071895 18 - 0.395 0.176 -1.569
ENSG00000119711 E017 68.1513252 0.0020570324 1.061468e-01 1.998409e-01 14 74071896 74071974 79 - 1.841 1.781 -0.205
ENSG00000119711 E018 0.8773789 0.3490704162 2.028582e-01 3.298023e-01 14 74071975 74072202 228 - 0.355 0.000 -11.982
ENSG00000119711 E019 47.1736936 0.0005116155 1.892005e-02 4.915721e-02 14 74072203 74072241 39 - 1.700 1.591 -0.371
ENSG00000119711 E020 85.5829971 0.0003227234 8.255739e-05 4.401241e-04 14 74072242 74072364 123 - 1.963 1.819 -0.484
ENSG00000119711 E021 74.0638046 0.0003640653 7.909165e-06 5.378204e-05 14 74072537 74072611 75 - 1.911 1.728 -0.617
ENSG00000119711 E022 55.6106843 0.0004315011 5.636020e-04 2.397770e-03 14 74074955 74075017 63 - 1.782 1.623 -0.538
ENSG00000119711 E023 41.2954867 0.0005196025 1.733143e-02 4.567301e-02 14 74084347 74084492 146 - 1.645 1.525 -0.411