ENSG00000119707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261973 ENSG00000119707 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM25 protein_coding protein_coding 46.0482 21.912 73.00539 2.517856 1.656595 1.735821 20.346027 12.7263000 30.861071 0.4573737 1.6381506 1.277309 0.4740750 0.59093333 0.42220000 -0.16873333 2.858459e-02 1.157529e-16 FALSE TRUE
ENST00000525321 ENSG00000119707 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM25 protein_coding protein_coding 46.0482 21.912 73.00539 2.517856 1.656595 1.735821 2.251211 0.0000000 4.123041 0.0000000 0.5799112 8.691060 0.0346750 0.00000000 0.05623333 0.05623333 1.157529e-16 1.157529e-16 FALSE TRUE
ENST00000531500 ENSG00000119707 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM25 protein_coding protein_coding 46.0482 21.912 73.00539 2.517856 1.656595 1.735821 6.861814 0.4601847 12.612080 0.4601847 1.2951748 4.746578 0.1091125 0.01716667 0.17360000 0.15643333 4.067330e-02 1.157529e-16 FALSE FALSE
ENST00000532483 ENSG00000119707 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM25 protein_coding processed_transcript 46.0482 21.912 73.00539 2.517856 1.656595 1.735821 14.158026 7.6897419 21.447079 1.6225701 1.4688107 1.478572 0.3225792 0.34356667 0.29343333 -0.05013333 6.268081e-01 1.157529e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119707 E001 0.0000000       14 73057585 73057632 48 +      
ENSG00000119707 E002 0.0000000       14 73057633 73057838 206 +      
ENSG00000119707 E003 0.0000000       14 73057839 73058140 302 +      
ENSG00000119707 E004 3.4466289 0.1055336659 1.954678e-01 3.205379e-01 14 73058141 73058531 391 + 0.691 0.417 -1.274
ENSG00000119707 E005 3.4466289 0.1055336659 1.954678e-01 3.205379e-01 14 73058532 73058532 1 + 0.691 0.417 -1.274
ENSG00000119707 E006 3.5938779 0.1031684723 1.651427e-01 2.818769e-01 14 73058533 73058533 1 + 0.707 0.417 -1.345
ENSG00000119707 E007 6.5646962 0.0033526053 8.002920e-03 2.378709e-02 14 73058534 73058541 8 + 0.937 0.568 -1.501
ENSG00000119707 E008 7.1495397 0.0071319515 3.862025e-03 1.275494e-02 14 73058542 73058543 2 + 0.974 0.568 -1.642
ENSG00000119707 E009 19.3940868 0.0016328214 1.148315e-03 4.465847e-03 14 73058544 73058546 3 + 1.346 1.072 -0.970
ENSG00000119707 E010 23.6033850 0.0016229467 5.455203e-03 1.716845e-02 14 73058547 73058548 2 + 1.410 1.208 -0.707
ENSG00000119707 E011 143.1491795 0.0024550467 2.545654e-07 2.390899e-06 14 73058549 73058667 119 + 2.172 1.987 -0.620
ENSG00000119707 E012 129.8103113 0.0015989196 1.247009e-09 1.814038e-08 14 73058668 73058705 38 + 2.139 1.919 -0.735
ENSG00000119707 E013 0.1451727 0.0427673635 1.000000e+00   14 73058706 73058811 106 + 0.078 0.000 -7.958
ENSG00000119707 E014 7.1114918 0.0934296059 7.240729e-01 8.177059e-01 14 73064972 73065093 122 + 0.849 0.970 0.458
ENSG00000119707 E015 1.2491050 0.0100213509 1.977933e-01 3.234744e-01 14 73069853 73069920 68 + 0.251 0.500 1.462
ENSG00000119707 E016 98.3027214 0.0012456960 2.937299e-05 1.751654e-04 14 73071627 73071636 10 + 2.004 1.852 -0.510
ENSG00000119707 E017 251.9657989 0.0039702550 4.978777e-06 3.544986e-05 14 73071637 73071747 111 + 2.408 2.260 -0.496
ENSG00000119707 E018 213.2079217 0.0056779281 6.289454e-05 3.456281e-04 14 73076319 73076368 50 + 2.336 2.186 -0.502
ENSG00000119707 E019 342.9400989 0.0111968701 4.821318e-03 1.543374e-02 14 73077369 73077536 168 + 2.534 2.418 -0.386
ENSG00000119707 E020 205.6063424 0.0051804411 1.532580e-03 5.741741e-03 14 73083494 73083551 58 + 2.310 2.203 -0.358
ENSG00000119707 E021 383.3156503 0.0006299603 5.109043e-09 6.654929e-08 14 73088001 73088161 161 + 2.578 2.473 -0.350
ENSG00000119707 E022 2.7583293 0.0388153064 2.998410e-01 4.414222e-01 14 73088370 73088474 105 + 0.595 0.419 -0.856
ENSG00000119707 E023 340.2951312 0.0005797949 6.297181e-12 1.354584e-10 14 73096915 73097035 121 + 2.535 2.397 -0.459
ENSG00000119707 E024 238.9890757 0.0002137082 1.258906e-06 1.023500e-05 14 73097036 73097100 65 + 2.371 2.275 -0.321
ENSG00000119707 E025 251.6916516 0.0004989102 5.614126e-04 2.390012e-03 14 73099380 73099433 54 + 2.384 2.324 -0.202
ENSG00000119707 E026 304.9241748 0.0027496035 1.213529e-05 7.907387e-05 14 73099667 73099750 84 + 2.483 2.364 -0.398
ENSG00000119707 E027 46.8164578 0.0028920742 3.797025e-17 1.718020e-15 14 73099751 73100300 550 + 1.758 1.128 -2.177
ENSG00000119707 E028 24.6691779 0.0255895201 6.137784e-06 4.283290e-05 14 73100301 73100362 62 + 1.478 0.935 -1.932
ENSG00000119707 E029 48.4387210 0.0222221191 2.935364e-11 5.662314e-10 14 73100363 73100713 351 + 1.779 1.074 -2.444
ENSG00000119707 E030 231.6157488 0.0029242618 3.084709e-41 1.150372e-38 14 73100714 73103191 2478 + 2.437 1.892 -1.823
ENSG00000119707 E031 656.1521153 0.0001345174 3.010353e-11 5.798112e-10 14 73103192 73103478 287 + 2.803 2.729 -0.245
ENSG00000119707 E032 192.6643172 0.0002008362 2.239093e-02 5.648855e-02 14 73105859 73105860 2 + 2.261 2.228 -0.111
ENSG00000119707 E033 628.0958570 0.0004499594 7.566476e-01 8.416985e-01 14 73105861 73106081 221 + 2.751 2.788 0.123
ENSG00000119707 E034 440.6732016 0.0015891525 8.401847e-02 1.658302e-01 14 73106196 73106279 84 + 2.586 2.661 0.251
ENSG00000119707 E035 258.1701598 0.0025717458 3.899950e-02 8.919666e-02 14 73106280 73106285 6 + 2.346 2.448 0.340
ENSG00000119707 E036 2.5173268 0.0059792684 4.232126e-01 5.663092e-01 14 73107302 73107825 524 + 0.471 0.627 0.725
ENSG00000119707 E037 396.0926838 0.0008790636 1.406868e-01 2.489603e-01 14 73107826 73107899 74 + 2.542 2.608 0.220
ENSG00000119707 E038 1.2952903 0.0101719766 8.473037e-01 9.051593e-01 14 73109131 73109341 211 + 0.338 0.318 -0.121
ENSG00000119707 E039 471.9291238 0.0013425207 5.624465e-01 6.900236e-01 14 73109342 73109492 151 + 2.624 2.669 0.150
ENSG00000119707 E040 678.5738442 0.0001048998 1.773355e-05 1.112735e-04 14 73110831 73111155 325 + 2.765 2.861 0.317
ENSG00000119707 E041 12.8798674 0.0013138399 3.102086e-02 7.395841e-02 14 73111156 73111308 153 + 1.162 0.959 -0.739
ENSG00000119707 E042 10.0817591 0.0016207970 1.404073e-02 3.831768e-02 14 73111309 73111382 74 + 1.078 0.806 -1.022
ENSG00000119707 E043 18.4480072 0.0025028513 1.043762e-02 2.983447e-02 14 73111383 73111527 145 + 1.305 1.092 -0.758
ENSG00000119707 E044 654.4674770 0.0015870341 7.951200e-08 8.234917e-07 14 73111528 73111802 275 + 2.727 2.883 0.521
ENSG00000119707 E045 304.0677241 0.0002527354 5.433764e-32 1.045087e-29 14 73112152 73112250 99 + 2.340 2.627 0.958
ENSG00000119707 E046 275.5430087 0.0016852357 2.314626e-19 1.378928e-17 14 73114286 73114333 48 + 2.295 2.588 0.979
ENSG00000119707 E047 1372.7671260 0.0054124185 9.280188e-12 1.944375e-10 14 73119713 73123899 4187 + 3.008 3.262 0.844