ENSG00000119689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334220 ENSG00000119689 HEK293_OSMI2_2hA HEK293_TMG_2hB DLST protein_coding protein_coding 85.71819 114.1183 74.62293 5.92126 0.8866005 -0.6127728 63.600712 94.674851 47.846369 6.4364249 1.5217750 -0.9844227 0.72582083 0.82820000 0.64086667 -0.18733333 4.163548e-08 7.366484e-20 FALSE TRUE
ENST00000555071 ENSG00000119689 HEK293_OSMI2_2hA HEK293_TMG_2hB DLST protein_coding retained_intron 85.71819 114.1183 74.62293 5.92126 0.8866005 -0.6127728 5.425658 2.130234 8.103682 0.1262792 0.6363351 1.9225879 0.07017917 0.01886667 0.10860000 0.08973333 7.366484e-20 7.366484e-20 FALSE TRUE
MSTRG.9918.4 ENSG00000119689 HEK293_OSMI2_2hA HEK293_TMG_2hB DLST protein_coding   85.71819 114.1183 74.62293 5.92126 0.8866005 -0.6127728 6.874997 9.083994 6.560693 1.4293477 0.9216207 -0.4688686 0.08284167 0.08083333 0.08823333 0.00740000 9.043213e-01 7.366484e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119689 E001 0.1451727 0.0432742160 2.654315e-01   14 74881891 74881902 12 + 0.155 0.000 -16.807
ENSG00000119689 E002 0.1451727 0.0432742160 2.654315e-01   14 74881903 74881905 3 + 0.155 0.000 -16.832
ENSG00000119689 E003 0.5838113 0.4114081620 2.594496e-01 3.968346e-01 14 74881906 74881906 1 + 0.358 0.094 -2.410
ENSG00000119689 E004 2.9849807 0.0162936393 4.156612e-01 5.590278e-01 14 74881907 74881913 7 + 0.647 0.540 -0.480
ENSG00000119689 E005 3.7912799 0.0091408179 8.808862e-01 9.276340e-01 14 74881914 74881914 1 + 0.647 0.649 0.008
ENSG00000119689 E006 3.9385289 0.0187108046 6.913258e-01 7.928229e-01 14 74881915 74881915 1 + 0.687 0.649 -0.160
ENSG00000119689 E007 8.8797505 0.0019310453 6.488076e-01 7.602577e-01 14 74881916 74881921 6 + 0.982 0.961 -0.080
ENSG00000119689 E008 9.2097481 0.0018180750 7.977008e-01 8.709300e-01 14 74881922 74881924 3 + 0.982 0.983 0.005
ENSG00000119689 E009 101.3280421 0.0021032027 8.031237e-03 2.385871e-02 14 74881925 74881940 16 + 2.033 1.953 -0.269
ENSG00000119689 E010 131.3198807 0.0036789985 5.932348e-03 1.843007e-02 14 74881941 74881953 13 + 2.149 2.061 -0.297
ENSG00000119689 E011 139.6451629 0.0029693316 3.671949e-04 1.647265e-03 14 74881954 74881955 2 + 2.191 2.078 -0.378
ENSG00000119689 E012 304.5414680 0.0075420481 2.321512e-02 5.819122e-02 14 74881956 74882016 61 + 2.505 2.429 -0.252
ENSG00000119689 E013 277.1698724 0.0041797313 4.384996e-02 9.810971e-02 14 74882591 74882624 34 + 2.445 2.399 -0.153
ENSG00000119689 E014 358.7622860 0.0025985746 2.445895e-03 8.600151e-03 14 74885586 74885634 49 + 2.568 2.505 -0.209
ENSG00000119689 E015 10.3667913 0.0016132388 4.259908e-15 1.480240e-13 14 74885635 74886024 390 + 1.392 0.597 -2.998
ENSG00000119689 E016 3.2554864 0.2006061173 3.093714e-03 1.054184e-02 14 74889069 74889094 26 + 0.960 0.237 -3.481
ENSG00000119689 E017 480.6982026 0.0015348458 1.626952e-03 6.046990e-03 14 74889095 74889147 53 + 2.684 2.637 -0.158
ENSG00000119689 E018 313.8316263 0.0006262800 9.995756e-04 3.956595e-03 14 74889275 74889276 2 + 2.499 2.452 -0.154
ENSG00000119689 E019 566.8304531 0.0001607244 1.135770e-03 4.423850e-03 14 74889277 74889349 73 + 2.739 2.719 -0.067
ENSG00000119689 E020 15.7648140 0.0010868741 6.248648e-16 2.424800e-14 14 74889350 74889733 384 + 1.522 0.855 -2.387
ENSG00000119689 E021 10.2946384 0.0097893884 2.630081e-04 1.228881e-03 14 74889878 74889896 19 + 1.239 0.870 -1.349
ENSG00000119689 E022 483.6992138 0.0003216320 4.432607e-01 5.848260e-01 14 74889897 74889952 56 + 2.645 2.663 0.062
ENSG00000119689 E023 355.1311502 0.0001589122 1.996924e-01 3.258466e-01 14 74891056 74891067 12 + 2.518 2.525 0.023
ENSG00000119689 E024 547.5145543 0.0001276409 5.259231e-02 1.137731e-01 14 74891068 74891167 100 + 2.710 2.711 0.004
ENSG00000119689 E025 19.3288933 0.0014219358 6.251777e-21 4.469360e-19 14 74891168 74891193 26 + 1.621 0.898 -2.564
ENSG00000119689 E026 33.9693044 0.0325955973 1.093270e-09 1.609549e-08 14 74891194 74891299 106 + 1.827 1.201 -2.155
ENSG00000119689 E027 107.8159710 0.0029042771 1.883606e-63 2.099079e-60 14 74891300 74892058 759 + 2.349 1.642 -2.374
ENSG00000119689 E028 550.9762710 0.0004795219 7.004437e-01 7.999142e-01 14 74892834 74892986 153 + 2.688 2.728 0.135
ENSG00000119689 E029 450.2172728 0.0001653088 3.884899e-02 8.890289e-02 14 74893348 74893424 77 + 2.630 2.625 -0.015
ENSG00000119689 E030 525.7595386 0.0003653533 5.673072e-02 1.210000e-01 14 74894312 74894409 98 + 2.694 2.692 -0.008
ENSG00000119689 E031 666.8271020 0.0007169120 1.431626e-01 2.523236e-01 14 74898369 74898499 131 + 2.793 2.798 0.015
ENSG00000119689 E032 565.7738115 0.0001389588 6.075338e-01 7.274837e-01 14 74899923 74899996 74 + 2.698 2.739 0.138
ENSG00000119689 E033 567.0882586 0.0001350782 2.841140e-02 6.884079e-02 14 74900289 74900372 84 + 2.679 2.748 0.230
ENSG00000119689 E034 843.0604855 0.0001051934 2.458905e-02 6.102952e-02 14 74901066 74901233 168 + 2.855 2.918 0.211
ENSG00000119689 E035 4008.4981672 0.0021271825 2.414228e-11 4.727267e-10 14 74902196 74903743 1548 + 3.471 3.615 0.480