ENSG00000119661

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553645 ENSG00000119661 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAL1 protein_coding protein_coding 5.439179 4.139614 8.364144 0.3380097 0.3027656 1.012964 1.8285085 0.8147275 3.3527259 0.1514340 0.1806844 2.0276417 0.31779167 0.20113333 0.40103333 0.19990000 0.01702826 0.01702826 FALSE TRUE
ENST00000555631 ENSG00000119661 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAL1 protein_coding protein_coding 5.439179 4.139614 8.364144 0.3380097 0.3027656 1.012964 2.8192496 2.8344450 4.2813933 0.3525862 0.2980229 0.5932989 0.52560000 0.68663333 0.51120000 -0.17543333 0.26112551 0.01702826 FALSE FALSE
MSTRG.9874.5 ENSG00000119661 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAL1 protein_coding   5.439179 4.139614 8.364144 0.3380097 0.3027656 1.012964 0.3711509 0.1340591 0.1659352 0.1340591 0.1014283 0.2883839 0.08029583 0.03503333 0.01936667 -0.01566667 0.90736676 0.01702826 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119661 E001 2.6873753 0.0058907200 3.062154e-02 7.318294e-02 14 73644875 73644985 111 + 0.440 0.682 1.116
ENSG00000119661 E002 2.6873753 0.0058907200 3.062154e-02 7.318294e-02 14 73644986 73644990 5 + 0.440 0.682 1.116
ENSG00000119661 E003 10.5512992 0.0019893857 2.392168e-04 1.129950e-03 14 73644991 73645008 18 + 0.931 1.175 0.891
ENSG00000119661 E004 11.7586757 0.0017643907 7.131095e-04 2.945588e-03 14 73645009 73645016 8 + 1.001 1.198 0.713
ENSG00000119661 E005 12.2036570 0.0016501106 8.239082e-04 3.344911e-03 14 73645017 73645017 1 + 1.022 1.210 0.675
ENSG00000119661 E006 16.3219328 0.0013331489 1.581669e-03 5.899172e-03 14 73645018 73645026 9 + 1.170 1.301 0.464
ENSG00000119661 E007 21.5181787 0.0013281151 2.493241e-03 8.744228e-03 14 73645027 73645042 16 + 1.302 1.392 0.313
ENSG00000119661 E008 1.3275450 0.0096765512 2.307510e-02 5.790385e-02 14 73651167 73651327 161 + 0.513 0.000 -17.197
ENSG00000119661 E009 7.7284325 0.0030396671 7.091038e-02 1.448509e-01 14 73653170 73653215 46 + 0.890 0.976 0.320
ENSG00000119661 E010 29.6140840 0.0008549862 4.950149e-05 2.792457e-04 14 73654847 73654885 39 + 1.420 1.542 0.417
ENSG00000119661 E011 25.5866778 0.0007881424 1.185650e-01 2.178894e-01 14 73658847 73658861 15 + 1.428 1.399 -0.101
ENSG00000119661 E012 44.1502426 0.0005498652 3.012565e-03 1.030276e-02 14 73658862 73658956 95 + 1.640 1.657 0.058
ENSG00000119661 E013 43.0185306 0.0005909896 9.395697e-02 1.813168e-01 14 73661987 73662042 56 + 1.654 1.605 -0.167
ENSG00000119661 E014 40.0673842 0.0005114908 1.620047e-02 4.316518e-02 14 73671542 73671597 56 + 1.611 1.605 -0.021
ENSG00000119661 E015 1.3327393 0.0775900414 2.830129e-01 4.230856e-01 14 73672945 73673091 147 + 0.302 0.430 0.755
ENSG00000119661 E016 54.6663714 0.0005382993 1.170509e-02 3.283084e-02 14 73687259 73687385 127 + 1.751 1.731 -0.070
ENSG00000119661 E017 48.9727561 0.0069016159 3.131356e-02 7.451090e-02 14 73689375 73689515 141 + 1.698 1.687 -0.036
ENSG00000119661 E018 0.2934659 0.0284728521 5.325763e-01   14 73689516 73689517 2 + 0.097 0.153 0.750
ENSG00000119661 E019 393.1821174 0.0217999656 3.423893e-07 3.130834e-06 14 73695902 73703732 7831 + 2.705 2.354 -1.168