ENSG00000119638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553823 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding protein_coding 46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 2.621627 2.0032111 4.323097 0.44699723 0.1536532 1.1058999 0.05823333 0.04583333 0.09333333 0.04750000 2.187666e-02 2.189623e-18 FALSE TRUE
ENST00000553945 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding nonsense_mediated_decay 46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 6.050682 3.8582932 6.108839 1.98717814 0.4902589 0.6615609 0.12804167 0.08906667 0.13203333 0.04296667 7.891155e-01 2.189623e-18 TRUE TRUE
ENST00000555405 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding retained_intron 46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 7.247141 13.9917656 1.993168 1.73343612 0.1324685 -2.8052534 0.15419583 0.32473333 0.04296667 -0.28176667 2.189623e-18 2.189623e-18 FALSE TRUE
ENST00000557026 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding retained_intron 46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 3.210897 1.7071920 3.207162 0.04426879 0.2523548 0.9057373 0.06891667 0.03973333 0.06920000 0.02946667 6.694239e-03 2.189623e-18 FALSE TRUE
ENST00000678749 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding protein_coding 46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 17.160403 14.2241694 18.811496 1.30435936 0.4067944 0.4030230 0.37115833 0.32783333 0.40596667 0.07813333 2.103168e-02 2.189623e-18 FALSE TRUE
MSTRG.9932.10 ENSG00000119638 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK9 protein_coding   46.46265 43.21627 46.35044 2.505624 0.4530111 0.1009861 2.007504 0.5798161 3.288949 0.30168255 0.7330477 2.4836693 0.04366667 0.01283333 0.07066667 0.05783333 5.156467e-03 2.189623e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119638 E001 8.6234198 0.0077036692 8.760860e-02 1.715081e-01 14 75079353 75081410 2058 - 1.067 0.907 -0.597
ENSG00000119638 E002 28.5833221 0.0007106423 1.232773e-01 2.246447e-01 14 75081411 75082118 708 - 1.401 1.536 0.464
ENSG00000119638 E003 6.1903160 0.0025961520 9.097006e-01 9.466171e-01 14 75082119 75082120 2 - 0.843 0.889 0.176
ENSG00000119638 E004 12.0002936 0.0016188368 2.775714e-01 4.171564e-01 14 75082121 75082128 8 - 1.043 1.181 0.494
ENSG00000119638 E005 63.5121130 0.0200620378 5.089852e-04 2.193202e-03 14 75082129 75082171 43 - 1.608 1.939 1.118
ENSG00000119638 E006 826.6676325 0.0020113428 2.599463e-27 3.458290e-25 14 75082172 75082789 618 - 2.740 3.033 0.974
ENSG00000119638 E007 1572.8074095 0.0015607431 5.735989e-19 3.250571e-17 14 75082790 75084086 1297 - 3.083 3.279 0.651
ENSG00000119638 E008 373.0482540 0.0005062887 3.961731e-05 2.285578e-04 14 75084087 75084329 243 - 2.507 2.627 0.401
ENSG00000119638 E009 455.4715116 0.0001459308 8.847370e-01 9.303181e-01 14 75084330 75084686 357 - 2.641 2.679 0.127
ENSG00000119638 E010 1.1071414 0.0111945186 6.958076e-01 7.963093e-01 14 75084859 75085095 237 - 0.353 0.303 -0.313
ENSG00000119638 E011 0.9631146 0.0151144038 4.093999e-01 5.530055e-01 14 75086429 75086647 219 - 0.353 0.224 -0.897
ENSG00000119638 E012 0.0000000       14 75086648 75086780 133 -      
ENSG00000119638 E013 5.8502785 0.0051364832 1.380790e-01 2.454023e-01 14 75086781 75086921 141 - 0.915 0.757 -0.615
ENSG00000119638 E014 2.9966511 0.0324134108 1.890703e-01 3.125747e-01 14 75086922 75087017 96 - 0.706 0.523 -0.805
ENSG00000119638 E015 290.8418718 0.0001683636 5.719944e-01 6.981802e-01 14 75087018 75087230 213 - 2.454 2.478 0.079
ENSG00000119638 E016 255.3180195 0.0019284537 4.078259e-01 5.514189e-01 14 75088480 75088641 162 - 2.406 2.414 0.028
ENSG00000119638 E017 234.2650345 0.0019478759 9.096159e-01 9.465491e-01 14 75091270 75091478 209 - 2.357 2.388 0.102
ENSG00000119638 E018 2.7044184 0.0058954373 2.610892e-02 6.416793e-02 14 75091479 75091685 207 - 0.706 0.371 -1.597
ENSG00000119638 E019 103.5514454 0.0003043126 8.585804e-02 1.687560e-01 14 75095372 75095431 60 - 1.967 2.063 0.322
ENSG00000119638 E020 0.5943067 0.0229843377 3.089240e-01 4.511968e-01 14 75096670 75097099 430 - 0.288 0.126 -1.484
ENSG00000119638 E021 231.8364182 0.0012319295 6.995983e-01 7.992747e-01 14 75097100 75097270 171 - 2.355 2.377 0.074
ENSG00000119638 E022 0.1482932 0.0411354124 4.891077e-01   14 75099027 75099317 291 - 0.000 0.126 9.199
ENSG00000119638 E023 294.1200831 0.0001823390 1.326053e-02 3.652575e-02 14 75100992 75101153 162 - 2.480 2.463 -0.055
ENSG00000119638 E024 258.2703759 0.0003554511 3.285286e-05 1.935706e-04 14 75101657 75101765 109 - 2.448 2.388 -0.201
ENSG00000119638 E025 7.5251305 0.0168035344 5.764694e-01 7.019024e-01 14 75103470 75103841 372 - 0.880 0.987 0.402
ENSG00000119638 E026 287.9810417 0.0001824412 3.202837e-04 1.461986e-03 14 75103842 75103997 156 - 2.486 2.446 -0.134
ENSG00000119638 E027 178.9674075 0.0017465423 2.471280e-03 8.677488e-03 14 75105950 75105996 47 - 2.289 2.222 -0.224
ENSG00000119638 E028 31.3715853 0.0033845944 3.380818e-03 1.138136e-02 14 75105997 75106190 194 - 1.591 1.430 -0.553
ENSG00000119638 E029 22.7784606 0.0008394663 1.642251e-01 2.806674e-01 14 75106191 75106395 205 - 1.412 1.347 -0.224
ENSG00000119638 E030 13.6199696 0.0015319134 8.751093e-01 9.237579e-01 14 75106396 75106465 70 - 1.152 1.171 0.068
ENSG00000119638 E031 19.1148197 0.0009637470 1.562939e-01 2.701906e-01 14 75106466 75106501 36 - 1.343 1.268 -0.263
ENSG00000119638 E032 298.4157043 0.0005787118 1.852268e-13 5.075305e-12 14 75106502 75106702 201 - 2.544 2.408 -0.451
ENSG00000119638 E033 254.1569998 0.0046169212 2.375445e-06 1.817899e-05 14 75107343 75107487 145 - 2.482 2.326 -0.523
ENSG00000119638 E034 9.9561084 0.0151475531 6.528441e-04 2.725836e-03 14 75107488 75107755 268 - 0.757 1.206 1.679
ENSG00000119638 E035 2.2418464 0.2039739654 8.242955e-02 1.633339e-01 14 75108270 75109684 1415 - 0.680 0.297 -1.948
ENSG00000119638 E036 321.0274073 0.0001375378 9.440234e-10 1.405883e-08 14 75109685 75109877 193 - 2.554 2.468 -0.286
ENSG00000119638 E037 208.2779062 0.0001897816 7.715283e-05 4.145900e-04 14 75110321 75110371 51 - 2.356 2.294 -0.206
ENSG00000119638 E038 209.2549591 0.0001810965 4.666259e-09 6.121096e-08 14 75113339 75113403 65 - 2.380 2.271 -0.362
ENSG00000119638 E039 0.7792333 0.0254599237 1.711562e-01 2.896851e-01 14 75113404 75113405 2 - 0.353 0.126 -1.897
ENSG00000119638 E040 265.9977933 0.0001687007 1.624044e-13 4.484988e-12 14 75114203 75114313 111 - 2.492 2.366 -0.420
ENSG00000119638 E041 1.8455766 0.0075368318 7.704979e-02 1.547640e-01 14 75116192 75116410 219 - 0.583 0.303 -1.483
ENSG00000119638 E042 152.9306343 0.0035263472 6.885501e-05 3.745370e-04 14 75117195 75117212 18 - 2.252 2.124 -0.429
ENSG00000119638 E043 230.5045689 0.0029794822 1.540996e-03 5.768936e-03 14 75117213 75117326 114 - 2.405 2.327 -0.261
ENSG00000119638 E044 129.5957050 0.0069360886 4.248818e-02 9.560636e-02 14 75118830 75118868 39 - 2.153 2.081 -0.241
ENSG00000119638 E045 154.0261235 0.0094970985 1.881551e-01 3.114162e-01 14 75118869 75118935 67 - 2.213 2.170 -0.142
ENSG00000119638 E046 103.0914541 0.0030277928 2.689087e-02 6.576467e-02 14 75120510 75120515 6 - 2.051 1.988 -0.211
ENSG00000119638 E047 147.3546588 0.0006142403 4.742946e-03 1.521423e-02 14 75120516 75120580 65 - 2.200 2.149 -0.173
ENSG00000119638 E048 1.5886544 0.0088055978 9.824280e-01 9.930639e-01 14 75120581 75120730 150 - 0.410 0.429 0.102
ENSG00000119638 E049 0.0000000       14 75120872 75121007 136 -      
ENSG00000119638 E050 124.2668630 0.0002260649 1.338338e-05 8.632619e-05 14 75121119 75121174 56 - 2.151 2.049 -0.343
ENSG00000119638 E051 174.9187724 0.0002289764 5.705834e-08 6.072430e-07 14 75124046 75124223 178 - 2.302 2.191 -0.372
ENSG00000119638 E052 18.3324637 0.0112428895 2.155503e-02 5.475671e-02 14 75126341 75126588 248 - 1.132 1.380 0.873
ENSG00000119638 E053 13.2809783 0.0168476290 7.991062e-02 1.594266e-01 14 75126589 75126702 114 - 1.018 1.238 0.791
ENSG00000119638 E054 172.2343904 0.0194826813 5.994834e-02 1.265182e-01 14 75126703 75126904 202 - 2.290 2.185 -0.351
ENSG00000119638 E055 111.1646185 0.0225631566 1.015484e-01 1.928354e-01 14 75126905 75127053 149 - 2.098 1.998 -0.337
ENSG00000119638 E056 3.1138235 0.0112438205 1.815062e-01 3.031296e-01 14 75127122 75127344 223 - 0.706 0.526 -0.793