ENSG00000119596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325680 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding protein_coding 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 4.185977 2.2271359 8.3803473 0.56942621 0.458508452 1.9070776 0.11477500 0.05693333 0.21796667 0.16103333 2.133345e-06 1.125807e-10 FALSE TRUE
ENST00000546901 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding processed_transcript 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 2.251161 2.4185785 1.8429075 0.34061579 0.009225769 -0.3903212 0.06413333 0.06403333 0.04786667 -0.01616667 4.786009e-01 1.125807e-10 FALSE FALSE
ENST00000547879 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding protein_coding 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 3.516995 4.9837238 2.3091834 0.36638175 0.474726966 -1.1064991 0.09770833 0.13180000 0.05946667 -0.07233333 7.533009e-03 1.125807e-10 FALSE TRUE
ENST00000549293 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding nonsense_mediated_decay 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 3.599271 8.6425310 0.4068112 0.10453320 0.146268459 -4.3756563 0.09897917 0.22886667 0.01050000 -0.21836667 1.125807e-10 1.125807e-10 TRUE TRUE
ENST00000550021 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding retained_intron 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 1.709163 0.5419872 2.1665005 0.21522481 0.270319781 1.9793036 0.05175000 0.01356667 0.05626667 0.04270000 1.818683e-02 1.125807e-10   FALSE
ENST00000552421 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding protein_coding 35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 4.896873 8.0093649 3.2133655 0.09553704 0.165910447 -1.3149202 0.13582083 0.21243333 0.08336667 -0.12906667 2.704321e-09 1.125807e-10 FALSE TRUE
MSTRG.9915.1 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding   35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 3.736567 4.4974936 2.8630371 0.21900582 0.234554192 -0.6497488 0.10608333 0.11856667 0.07410000 -0.04446667 3.861405e-03 1.125807e-10 TRUE TRUE
MSTRG.9915.5 ENSG00000119596 HEK293_OSMI2_2hA HEK293_TMG_2hB YLPM1 protein_coding   35.55077 38.11588 38.53797 2.655581 0.7757666 0.0158844 10.837575 6.3968448 16.5061672 1.69727037 0.503900999 1.3661930 0.30660417 0.16323333 0.42830000 0.26506667 2.615246e-04 1.125807e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119596 E001 12.1608942 0.0025919435 3.300101e-07 3.026842e-06 14 74763316 74763365 50 + 1.355 0.818 -1.957
ENSG00000119596 E002 157.8401778 0.0187234349 6.748491e-10 1.033450e-08 14 74763366 74763990 625 + 2.419 1.942 -1.596
ENSG00000119596 E003 224.3829566 0.0098242478 1.021501e-11 2.123330e-10 14 74763991 74764362 372 + 2.541 2.144 -1.327
ENSG00000119596 E004 0.8856842 0.0763943422 5.941264e-03 1.845383e-02 14 74771692 74771746 55 + 0.516 0.000 -12.013
ENSG00000119596 E005 212.2379057 0.0121922402 5.221624e-11 9.663193e-10 14 74778447 74778683 237 + 2.526 2.107 -1.400
ENSG00000119596 E006 179.5544485 0.0104345434 2.033610e-11 4.024037e-10 14 74780405 74780584 180 + 2.451 2.039 -1.377
ENSG00000119596 E007 90.4033555 0.0003175370 5.721224e-20 3.613612e-18 14 74781334 74781384 51 + 2.140 1.758 -1.284
ENSG00000119596 E008 607.8579832 0.0027348471 2.084230e-25 2.371478e-23 14 74781385 74782325 941 + 2.944 2.615 -1.096
ENSG00000119596 E009 1583.1195682 0.0030238097 3.606473e-13 9.480165e-12 14 74797580 74799697 2118 + 3.306 3.093 -0.709
ENSG00000119596 E010 290.0476688 0.0012416853 1.075154e-03 4.218561e-03 14 74802556 74802676 121 + 2.521 2.398 -0.413
ENSG00000119596 E011 419.6086889 0.0010167621 6.133400e-01 7.320320e-01 14 74809380 74809631 252 + 2.638 2.590 -0.159
ENSG00000119596 E012 339.2599044 0.0016871981 4.902931e-02 1.074307e-01 14 74809632 74809797 166 + 2.569 2.481 -0.296
ENSG00000119596 E013 300.6362628 0.0033960551 1.381600e-01 2.455231e-01 14 74809910 74810002 93 + 2.514 2.430 -0.281
ENSG00000119596 E014 473.0555803 0.0005026815 1.931274e-01 3.176983e-01 14 74810225 74810420 196 + 2.696 2.635 -0.205
ENSG00000119596 E015 404.2416158 0.0001787931 7.384511e-01 8.283291e-01 14 74811620 74811738 119 + 2.616 2.573 -0.145
ENSG00000119596 E016 442.6467167 0.0005775860 3.129315e-01 4.554454e-01 14 74812628 74812782 155 + 2.639 2.623 -0.052
ENSG00000119596 E017 268.5304020 0.0002461161 7.106114e-04 2.936806e-03 14 74816203 74816265 63 + 2.386 2.427 0.136
ENSG00000119596 E018 362.2939854 0.0001788247 5.177983e-08 5.567272e-07 14 74816571 74816690 120 + 2.497 2.567 0.236
ENSG00000119596 E019 456.6671747 0.0001664965 1.202262e-11 2.470335e-10 14 74816931 74817107 177 + 2.590 2.673 0.278
ENSG00000119596 E020 273.7903478 0.0002914212 1.220451e-08 1.481550e-07 14 74817194 74817237 44 + 2.360 2.455 0.319
ENSG00000119596 E021 246.4868839 0.0006148099 3.230817e-07 2.969189e-06 14 74817238 74817277 40 + 2.315 2.411 0.320
ENSG00000119596 E022 365.7013842 0.0009568984 6.738339e-10 1.032146e-08 14 74818231 74818308 78 + 2.474 2.587 0.377
ENSG00000119596 E023 251.1414496 0.0020944805 3.697446e-06 2.713423e-05 14 74818309 74818314 6 + 2.311 2.424 0.377
ENSG00000119596 E024 468.6763322 0.0024032165 2.804366e-09 3.829036e-08 14 74821057 74821137 81 + 2.566 2.704 0.458
ENSG00000119596 E025 67.7741345 0.0162084227 2.689014e-02 6.576435e-02 14 74821138 74822115 978 + 1.738 1.869 0.442
ENSG00000119596 E026 9.9603279 0.0051935901 1.065128e-06 8.787413e-06 14 74823978 74824255 278 + 1.284 0.715 -2.122
ENSG00000119596 E027 412.3062276 0.0030928068 8.439563e-08 8.691763e-07 14 74824256 74824307 52 + 2.510 2.649 0.462
ENSG00000119596 E028 38.8574334 0.0033362601 6.277711e-01 7.434990e-01 14 74827372 74828032 661 + 1.587 1.581 -0.019
ENSG00000119596 E029 547.9188428 0.0013119031 2.059082e-20 1.382797e-18 14 74829213 74829343 131 + 2.603 2.785 0.604
ENSG00000119596 E030 4.5673080 0.0035861373 1.319182e-01 2.367875e-01 14 74834898 74835264 367 + 0.873 0.638 -0.950
ENSG00000119596 E031 591.3696694 0.0046793639 4.219020e-13 1.098466e-11 14 74835265 74835447 183 + 2.604 2.832 0.759
ENSG00000119596 E032 405.9650623 0.0063181142 8.923409e-12 1.874183e-10 14 74835775 74835908 134 + 2.418 2.677 0.865
ENSG00000119596 E033 297.9852012 0.0017857824 2.451563e-21 1.827155e-19 14 74835909 74837318 1410 + 2.290 2.540 0.835
ENSG00000119596 E034 0.9577154 0.0216427047 7.877020e-01 8.639917e-01 14 74844024 74844260 237 + 0.330 0.264 -0.448
ENSG00000119596 E035 418.1368033 0.0011472494 1.273821e-05 8.259628e-05 14 74855217 74859435 4219 + 2.563 2.632 0.228