ENSG00000119559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585675 ENSG00000119559 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf25 protein_coding protein_coding 62.23214 113.1573 27.73881 6.08741 1.09175 -2.027959 14.825203 28.746905 4.3906757 1.7027291 0.3267317 -2.7081115 0.22541667 0.25393333 0.15790000 -0.09603333 1.565139e-08 3.142096e-28 FALSE TRUE
ENST00000586564 ENSG00000119559 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf25 protein_coding protein_coding 62.23214 113.1573 27.73881 6.08741 1.09175 -2.027959 22.593617 51.791160 8.0537797 0.1875143 0.4315106 -2.6834563 0.31658750 0.46043333 0.29140000 -0.16903333 1.206290e-03 3.142096e-28 FALSE TRUE
ENST00000588427 ENSG00000119559 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf25 protein_coding protein_coding 62.23214 113.1573 27.73881 6.08741 1.09175 -2.027959 9.433072 9.631151 8.6760088 0.8551239 0.2118709 -0.1505119 0.18887500 0.08483333 0.31410000 0.22926667 3.142096e-28 3.142096e-28 FALSE FALSE
ENST00000592872 ENSG00000119559 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf25 protein_coding protein_coding 62.23214 113.1573 27.73881 6.08741 1.09175 -2.027959 5.225938 10.651205 0.6838302 2.6399267 0.6838302 -3.9416442 0.07434583 0.09223333 0.02416667 -0.06806667 1.302354e-01 3.142096e-28 FALSE TRUE
ENST00000651077 ENSG00000119559 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf25 protein_coding protein_coding 62.23214 113.1573 27.73881 6.08741 1.09175 -2.027959 2.762969 3.791046 1.2030288 1.0262893 0.3292226 -1.6477828 0.05106667 0.03280000 0.04303333 0.01023333 7.542290e-01 3.142096e-28 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119559 E001 260.619022 0.0003808970 2.429430e-138 2.001079e-134 19 1461143 1461824 682 - 2.702 2.095 -2.024
ENSG00000119559 E002 4.824146 0.0036471582 6.733608e-01 7.790680e-01 19 1473201 1473203 3 - 0.687 0.618 -0.294
ENSG00000119559 E003 449.249845 0.0001284304 3.171444e-04 1.449262e-03 19 1473204 1474154 951 - 2.391 2.485 0.314
ENSG00000119559 E004 65.539046 0.0025213681 7.322792e-02 1.486840e-01 19 1474155 1474167 13 - 1.524 1.657 0.453
ENSG00000119559 E005 66.418296 0.0020740169 5.628205e-02 1.202082e-01 19 1474168 1474171 4 - 1.524 1.663 0.474
ENSG00000119559 E006 64.506760 0.0004236083 6.982657e-02 1.430890e-01 19 1474172 1474173 2 - 1.524 1.651 0.431
ENSG00000119559 E007 67.534437 0.0003823585 4.270891e-02 9.601143e-02 19 1474174 1474175 2 - 1.534 1.673 0.472
ENSG00000119559 E008 78.757646 0.0003506989 8.637568e-03 2.537901e-02 19 1474176 1474185 10 - 1.572 1.741 0.574
ENSG00000119559 E009 767.800956 0.0007383164 2.590440e-08 2.955086e-07 19 1474186 1474478 293 - 2.594 2.723 0.430
ENSG00000119559 E010 1564.861470 0.0005265650 8.758813e-12 1.841655e-10 19 1474479 1475054 576 - 2.926 3.030 0.346
ENSG00000119559 E011 442.145744 0.0001315895 3.542521e-06 2.609636e-05 19 1475055 1475145 91 - 2.358 2.481 0.409
ENSG00000119559 E012 375.311229 0.0001777703 2.871454e-04 1.327734e-03 19 1475146 1475239 94 - 2.302 2.407 0.351
ENSG00000119559 E013 203.637933 0.0010278011 1.644737e-02 4.372035e-02 19 1475240 1475258 19 - 2.044 2.146 0.339
ENSG00000119559 E014 44.689718 0.0005026406 2.118491e-05 1.306111e-04 19 1475259 1475514 256 - 1.709 1.439 -0.924
ENSG00000119559 E015 19.945349 0.0010664981 4.009170e-05 2.310202e-04 19 1475515 1475903 389 - 1.448 1.083 -1.284
ENSG00000119559 E016 23.904812 0.0008755539 4.441884e-09 5.841733e-08 19 1475904 1476294 391 - 1.598 1.138 -1.600
ENSG00000119559 E017 18.179219 0.0010307111 8.249092e-05 4.398069e-04 19 1476295 1476485 191 - 1.410 1.047 -1.285
ENSG00000119559 E018 8.994481 0.0127168224 1.709790e-04 8.393091e-04 19 1478413 1478434 22 - 1.216 0.743 -1.767
ENSG00000119559 E019 18.627529 0.0009913721 1.036618e-10 1.824622e-09 19 1478435 1478580 146 - 1.553 1.002 -1.942
ENSG00000119559 E020 8.713675 0.0023596495 8.124821e-06 5.509227e-05 19 1478581 1478653 73 - 1.236 0.709 -1.979
ENSG00000119559 E021 12.870641 0.0194782922 1.394146e-05 8.958272e-05 19 1478654 1478773 120 - 1.369 0.861 -1.838
ENSG00000119559 E022 310.510030 0.0007378028 3.097631e-03 1.055329e-02 19 1478774 1478905 132 - 2.384 2.303 -0.271
ENSG00000119559 E023 13.101383 0.0014148808 9.478174e-03 2.748399e-02 19 1478906 1479113 208 - 1.216 0.932 -1.034
ENSG00000119559 E024 9.097153 0.0018762989 2.737240e-02 6.675015e-02 19 1479114 1479139 26 - 1.073 0.793 -1.053
ENSG00000119559 E025 11.450201 0.0015983333 2.392373e-02 5.964468e-02 19 1479140 1479162 23 - 1.150 0.888 -0.967
ENSG00000119559 E026 91.067801 0.0003420345 1.376357e-02 3.768342e-02 19 1479163 1479219 57 - 1.885 1.767 -0.398