ENSG00000119537

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000591902 ENSG00000119537 HEK293_OSMI2_2hA HEK293_TMG_2hB KDSR protein_coding protein_coding 18.14833 13.59804 23.48734 0.3146178 0.4792447 0.7880382 2.295096 0.3186060 5.014219 0.1096505 0.84442282 3.9344684 0.11074583 0.02353333 0.21246667 0.1889333 2.912054e-05 8.621772e-15 FALSE TRUE
ENST00000644624 ENSG00000119537 HEK293_OSMI2_2hA HEK293_TMG_2hB KDSR protein_coding nonsense_mediated_decay 18.14833 13.59804 23.48734 0.3146178 0.4792447 0.7880382 3.121753 3.5102050 0.000000 0.8423288 0.00000000 -8.4595156 0.18541250 0.26096667 0.00000000 -0.2609667 8.621772e-15 8.621772e-15 FALSE TRUE
ENST00000645214 ENSG00000119537 HEK293_OSMI2_2hA HEK293_TMG_2hB KDSR protein_coding protein_coding 18.14833 13.59804 23.48734 0.3146178 0.4792447 0.7880382 3.113897 1.9338958 5.041775 0.2491297 0.30131136 1.3778394 0.15981667 0.14250000 0.21490000 0.0724000 1.312754e-01 8.621772e-15 FALSE TRUE
ENST00000646205 ENSG00000119537 HEK293_OSMI2_2hA HEK293_TMG_2hB KDSR protein_coding nonsense_mediated_decay 18.14833 13.59804 23.48734 0.3146178 0.4792447 0.7880382 1.000357 0.8408367 1.656407 0.3843360 0.09840446 0.9697867 0.05537917 0.06103333 0.07043333 0.0094000 7.897624e-01 8.621772e-15 FALSE TRUE
MSTRG.15884.2 ENSG00000119537 HEK293_OSMI2_2hA HEK293_TMG_2hB KDSR protein_coding   18.14833 13.59804 23.48734 0.3146178 0.4792447 0.7880382 7.449044 6.3473650 10.540579 0.8674046 0.51657207 0.7308214 0.42364167 0.46440000 0.44980000 -0.0146000 9.538682e-01 8.621772e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119537 E001 255.7956330 0.0073845990 2.721990e-04 1.266580e-03 18 63327726 63330824 3099 - 2.476 2.310 -0.552
ENSG00000119537 E002 47.4612674 0.0005429112 4.820768e-10 7.565902e-09 18 63330825 63330841 17 - 1.517 1.828 1.056
ENSG00000119537 E003 41.8323321 0.0006539880 9.972594e-07 8.275781e-06 18 63330842 63330843 2 - 1.499 1.756 0.875
ENSG00000119537 E004 311.6795748 0.0011596265 7.661835e-22 5.985615e-20 18 63330844 63331382 539 - 2.382 2.602 0.736
ENSG00000119537 E005 83.2005123 0.0004796682 9.836522e-08 1.000107e-06 18 63331383 63331403 21 - 1.822 2.022 0.672
ENSG00000119537 E006 210.4861061 0.0001918986 1.267426e-05 8.224638e-05 18 63331404 63331642 239 - 2.278 2.375 0.323
ENSG00000119537 E007 81.5452747 0.0003240512 7.831734e-02 1.567762e-01 18 63331643 63331650 8 - 1.889 1.950 0.204
ENSG00000119537 E008 172.3856388 0.0003639234 1.683717e-02 4.457113e-02 18 63331651 63331901 251 - 2.213 2.270 0.190
ENSG00000119537 E009 108.2289579 0.0003257422 5.902271e-01 7.131219e-01 18 63335257 63335358 102 - 2.051 2.025 -0.087
ENSG00000119537 E010 1.9563045 0.0074429603 9.075109e-01 9.452921e-01 18 63335359 63336023 665 - 0.459 0.474 0.074
ENSG00000119537 E011 136.3002751 0.0010293007 1.787322e-04 8.724402e-04 18 63338800 63338883 84 - 2.192 2.059 -0.446
ENSG00000119537 E012 0.6287620 0.0181194289 6.912287e-01 7.927404e-01 18 63344342 63344409 68 - 0.186 0.253 0.557
ENSG00000119537 E013 132.0622772 0.0002652467 2.418535e-02 6.019077e-02 18 63344410 63344493 84 - 2.157 2.079 -0.261
ENSG00000119537 E014 0.3686942 0.0313011938 7.652579e-01 8.480746e-01 18 63344494 63346457 1964 - 0.103 0.145 0.561
ENSG00000119537 E015 0.0000000       18 63346458 63346616 159 -      
ENSG00000119537 E016 136.4982634 0.0003055430 1.412611e-02 3.851183e-02 18 63350888 63351014 127 - 2.173 2.090 -0.279
ENSG00000119537 E017 101.6272197 0.0046053290 5.387509e-01 6.701392e-01 18 63351015 63351077 63 - 2.026 1.987 -0.133
ENSG00000119537 E018 61.6299313 0.0144677541 6.488568e-01 7.602683e-01 18 63351078 63351079 2 - 1.811 1.769 -0.143
ENSG00000119537 E019 64.8771841 0.0089900957 6.687493e-01 7.756856e-01 18 63355204 63355218 15 - 1.831 1.794 -0.125
ENSG00000119537 E020 120.1149757 0.0052189695 1.299215e-01 2.340529e-01 18 63355219 63355299 81 - 2.115 2.033 -0.275
ENSG00000119537 E021 0.4804688 0.0222754901 8.269853e-01 8.911652e-01 18 63355316 63355497 182 - 0.187 0.145 -0.441
ENSG00000119537 E022 100.2798495 0.0017449679 5.317025e-03 1.679529e-02 18 63355498 63355563 66 - 2.052 1.931 -0.408
ENSG00000119537 E023 0.4815130 0.0205144111 3.585574e-01 5.029711e-01 18 63359525 63359735 211 - 0.103 0.253 1.555
ENSG00000119537 E024 89.3848854 0.0003822005 1.716957e-04 8.424346e-04 18 63359736 63359792 57 - 2.014 1.860 -0.515
ENSG00000119537 E025 80.2943638 0.0003779600 2.502375e-04 1.176200e-03 18 63362779 63362842 64 - 1.970 1.813 -0.527
ENSG00000119537 E026 55.8535623 0.0005805760 3.563334e-04 1.604695e-03 18 63362843 63362868 26 - 1.826 1.644 -0.616
ENSG00000119537 E027 8.7527614 0.0019031656 2.290688e-01 3.613145e-01 18 63365962 63366249 288 - 1.049 0.909 -0.520
ENSG00000119537 E028 5.5272135 0.0030452099 7.373176e-01 8.275477e-01 18 63366250 63366308 59 - 0.804 0.840 0.143
ENSG00000119537 E029 9.1455661 0.0264378887 9.517113e-01 9.737463e-01 18 63366405 63366674 270 - 1.005 1.004 -0.005
ENSG00000119537 E030 71.2651755 0.0030158140 3.820097e-07 3.457579e-06 18 63367011 63367228 218 - 1.957 1.689 -0.904