ENSG00000119522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373624 ENSG00000119522 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1A protein_coding protein_coding 14.9894 21.17163 13.0266 0.9577403 0.1095197 -0.7002461 6.0801017 9.0230784 4.1148485 0.4957960 0.2826093 -1.1308766 0.3952542 0.42930000 0.3155667 -0.11373333 0.1703233226 0.0001453872 FALSE TRUE
ENST00000475421 ENSG00000119522 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1A protein_coding processed_transcript 14.9894 21.17163 13.0266 0.9577403 0.1095197 -0.7002461 2.6960577 5.7030354 1.6071250 0.4309834 0.1512662 -1.8208263 0.1613958 0.27033333 0.1234333 -0.14690000 0.0001453872 0.0001453872 FALSE FALSE
MSTRG.33350.15 ENSG00000119522 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1A protein_coding   14.9894 21.17163 13.0266 0.9577403 0.1095197 -0.7002461 0.7682344 0.6259084 0.8977461 0.1875948 0.3795905 0.5134699 0.0562375 0.02886667 0.0685000 0.03963333 0.6914776625 0.0001453872 FALSE TRUE
MSTRG.33350.8 ENSG00000119522 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1A protein_coding   14.9894 21.17163 13.0266 0.9577403 0.1095197 -0.7002461 3.8361482 3.8516713 4.9237255 0.7735241 0.4575652 0.3534521 0.2695625 0.17940000 0.3786000 0.19920000 0.0111257960 0.0001453872 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119522 E001 1.3597311 0.0096765512 1.572062e-02 4.210693e-02 9 123379654 123379657 4 - 0.000 0.472 13.128
ENSG00000119522 E002 77.2465081 0.0019856795 6.877221e-16 2.655123e-14 9 123379658 123379880 223 - 1.516 1.962 1.510
ENSG00000119522 E003 332.4952191 0.0038283756 5.890629e-10 9.121063e-09 9 123379881 123380820 940 - 2.325 2.554 0.762
ENSG00000119522 E004 124.9412740 0.0067589805 4.189968e-01 5.622565e-01 9 123380821 123381033 213 - 2.030 2.084 0.180
ENSG00000119522 E005 135.5043367 0.0052562222 4.328318e-02 9.708007e-02 9 123381034 123381435 402 - 2.029 2.136 0.359
ENSG00000119522 E006 126.9714418 0.0071723993 1.118434e-03 4.365092e-03 9 123381436 123382219 784 - 1.942 2.126 0.620
ENSG00000119522 E007 100.4568509 0.0077768258 5.991261e-02 1.264584e-01 9 123382220 123382625 406 - 1.890 2.010 0.403
ENSG00000119522 E008 81.3925638 0.0007333176 5.008245e-01 6.370330e-01 9 123383655 123383913 259 - 1.857 1.899 0.141
ENSG00000119522 E009 6.2196087 0.0413596581 5.454559e-01 6.757940e-01 9 123387730 123387858 129 - 0.759 0.868 0.430
ENSG00000119522 E010 0.2966881 0.0272477047 8.468146e-02   9 123400099 123400169 71 - 0.270 0.000 -13.018
ENSG00000119522 E011 0.8544736 0.0183793058 8.433820e-01 9.024711e-01 9 123400170 123400231 62 - 0.270 0.240 -0.221
ENSG00000119522 E012 7.0417512 0.0025162636 8.387368e-01 8.992120e-01 9 123400232 123401547 1316 - 0.847 0.884 0.143
ENSG00000119522 E013 26.0186296 0.0014511740 5.657466e-02 1.207161e-01 9 123401548 123401704 157 - 1.300 1.455 0.540
ENSG00000119522 E014 80.1692252 0.0087286507 9.802376e-03 2.827521e-02 9 123401705 123401912 208 - 1.755 1.935 0.605
ENSG00000119522 E015 100.5690330 0.0018697445 1.223678e-01 2.233232e-01 9 123403402 123403474 73 - 1.927 2.007 0.268
ENSG00000119522 E016 61.2977765 0.0010274956 1.421314e-01 2.509377e-01 9 123403475 123403490 16 - 1.710 1.797 0.293
ENSG00000119522 E017 0.0000000       9 123403491 123403573 83 -      
ENSG00000119522 E018 0.2965864 0.1835700143 4.675916e-01   9 123411293 123411775 483 - 0.000 0.171 11.103
ENSG00000119522 E019 1.8026215 0.0081063772 5.884550e-03 1.830799e-02 9 123411776 123411829 54 - 0.000 0.539 13.453
ENSG00000119522 E020 0.5149111 0.0207435639 9.541017e-01 9.752456e-01 9 123413271 123414588 1318 - 0.155 0.174 0.195
ENSG00000119522 E021 0.0000000       9 123437647 123437832 186 -      
ENSG00000119522 E022 1.0934354 0.2637439532 4.333023e-01 5.757034e-01 9 123439727 123440189 463 - 0.155 0.354 1.550
ENSG00000119522 E023 130.1781521 0.0003487428 9.559779e-02 1.837849e-01 9 123440360 123440491 132 - 2.044 2.114 0.232
ENSG00000119522 E024 99.3220245 0.0023404122 5.136248e-01 6.484126e-01 9 123450693 123450749 57 - 1.985 1.972 -0.044
ENSG00000119522 E025 103.2700323 0.0021541869 3.754198e-01 5.198532e-01 9 123452276 123452347 72 - 2.007 1.985 -0.075
ENSG00000119522 E026 73.6277079 0.0020857028 7.772824e-01 8.566747e-01 9 123454739 123454779 41 - 1.847 1.848 0.004
ENSG00000119522 E027 0.5911836 0.0624432214 2.244390e-01 3.557356e-01 9 123456847 123456931 85 - 0.000 0.241 11.724
ENSG00000119522 E028 105.4425886 0.0011847270 6.065198e-02 1.277272e-01 9 123457348 123457435 88 - 2.039 1.982 -0.193
ENSG00000119522 E029 101.6361104 0.0002991546 4.840448e-03 1.548660e-02 9 123457793 123457897 105 - 2.041 1.953 -0.293
ENSG00000119522 E030 0.3697384 0.0252010123 4.101430e-01 5.537566e-01 9 123461914 123462023 110 - 0.000 0.174 11.132
ENSG00000119522 E031 108.9569735 0.0012713940 4.497509e-03 1.453585e-02 9 123557570 123557695 126 - 2.074 1.980 -0.314
ENSG00000119522 E032 5.3200350 0.0305513001 1.957140e-01 3.208528e-01 9 123569443 123569544 102 - 0.896 0.714 -0.721
ENSG00000119522 E033 5.1758047 0.0783768629 8.907652e-01 9.342225e-01 9 123569545 123569595 51 - 0.789 0.767 -0.087
ENSG00000119522 E034 97.9102594 0.0020719477 2.628344e-03 9.154170e-03 9 123583169 123583270 102 - 2.041 1.930 -0.373
ENSG00000119522 E035 60.9340768 0.0066472236 5.212660e-02 1.129470e-01 9 123609436 123609481 46 - 1.833 1.735 -0.332
ENSG00000119522 E036 55.7152103 0.0004506882 2.242480e-01 3.555072e-01 9 123630376 123630395 20 - 1.759 1.713 -0.153
ENSG00000119522 E037 76.5449983 0.0004967251 1.151723e-02 3.238978e-02 9 123630396 123630476 81 - 1.924 1.833 -0.306
ENSG00000119522 E038 97.9726019 0.0015050064 1.008663e-02 2.897471e-02 9 123652013 123652123 111 - 2.029 1.940 -0.297
ENSG00000119522 E039 0.0000000       9 123652124 123652291 168 -      
ENSG00000119522 E040 75.9233608 0.0019335293 6.755403e-02 1.392879e-01 9 123667026 123667079 54 - 1.906 1.837 -0.232
ENSG00000119522 E041 86.1957668 0.0053716561 1.653241e-01 2.821026e-01 9 123671291 123671371 81 - 1.953 1.897 -0.188
ENSG00000119522 E042 95.3734969 0.0002931419 1.741797e-04 8.534289e-04 9 123676720 123676789 70 - 2.037 1.914 -0.416
ENSG00000119522 E043 123.7064736 0.0013768395 4.793863e-03 1.535779e-02 9 123757703 123757822 120 - 2.123 2.033 -0.299
ENSG00000119522 E044 78.0721738 0.0098293652 5.403118e-03 1.702348e-02 9 123769514 123769563 50 - 1.967 1.810 -0.530
ENSG00000119522 E045 74.1252567 0.0032479834 3.285167e-06 2.438544e-05 9 123792587 123792630 44 - 1.977 1.764 -0.718
ENSG00000119522 E046 0.0000000       9 123798261 123798515 255 -      
ENSG00000119522 E047 72.8804036 0.0065974272 1.729514e-02 4.559567e-02 9 123878951 123879021 71 - 1.916 1.795 -0.407
ENSG00000119522 E048 2.5226504 0.3420837752 4.147364e-01 5.581405e-01 9 123928595 123928727 133 - 0.690 0.428 -1.216
ENSG00000119522 E049 46.3036932 0.0090060883 4.898245e-03 1.564668e-02 9 123929889 123930152 264 - 1.759 1.577 -0.616