ENSG00000119509

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262456 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding protein_coding 5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 0.8690326 0.58139211 1.4550149 0.19416881 0.03964672 1.3087284 0.15931250 0.18393333 0.21516667 0.031233333 8.169535e-01 1.251966e-05 FALSE  
ENST00000262457 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding protein_coding 5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 2.4463451 1.73106159 2.3188859 0.17785908 0.31459094 0.4196727 0.49997083 0.57390000 0.33916667 -0.234733333 1.035532e-01 1.251966e-05 FALSE  
ENST00000460636 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding processed_transcript 5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 0.3923681 0.18998804 0.8151757 0.06101664 0.35405804 2.0447876 0.06949167 0.06060000 0.11503333 0.054433333 7.770494e-01 1.251966e-05 FALSE  
MSTRG.33154.3 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding   5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 0.2501709 0.08835611 0.5752438 0.04440157 0.31051019 2.5729513 0.04454583 0.02796667 0.09040000 0.062433333 6.246538e-01 1.251966e-05 FALSE  
MSTRG.33154.7 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding   5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 0.3190408 0.00000000 0.4599369 0.00000000 0.04504250 5.5543951 0.06036667 0.00000000 0.06773333 0.067733333 1.251966e-05 1.251966e-05 TRUE  
MSTRG.33154.9 ENSG00000119509 HEK293_OSMI2_2hA HEK293_TMG_2hB INVS protein_coding   5.127959 3.074793 6.787421 0.1898168 0.361728 1.139814 0.2639355 0.18939510 0.3794529 0.17055303 0.20445881 0.9658187 0.05773333 0.05556667 0.05720000 0.001633333 9.429961e-01 1.251966e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119509 E001 0.5996172 0.3546178792 7.126695e-01 0.8093291254 9 100099243 100099250 8 + 0.177 0.260 0.700
ENSG00000119509 E002 1.4381962 0.0133093395 8.557674e-02 0.1683288514 9 100099251 100099260 10 + 0.243 0.548 1.753
ENSG00000119509 E003 1.8757906 0.0079821312 3.951104e-01 0.5389491254 9 100099261 100099271 11 + 0.398 0.548 0.754
ENSG00000119509 E004 1.8757906 0.0079821312 3.951104e-01 0.5389491254 9 100099272 100099274 3 + 0.398 0.548 0.754
ENSG00000119509 E005 2.4690651 0.0146236025 3.420416e-01 0.4860358282 9 100099275 100099287 13 + 0.478 0.641 0.750
ENSG00000119509 E006 3.4215837 0.0184818662 4.968479e-01 0.6334422438 9 100099288 100099302 15 + 0.603 0.717 0.487
ENSG00000119509 E007 17.2226773 0.0140414281 8.636695e-01 0.9160928149 9 100099303 100099416 114 + 1.262 1.252 -0.035
ENSG00000119509 E008 4.5340753 0.0051261140 5.352958e-02 0.1154264022 9 100101301 100102017 717 + 0.830 0.549 -1.182
ENSG00000119509 E009 17.6458542 0.0010799095 6.072925e-02 0.1278614545 9 100104498 100104538 41 + 1.323 1.175 -0.522
ENSG00000119509 E010 26.7249253 0.0007840684 1.097714e-01 0.2052229115 9 100104539 100104627 89 + 1.478 1.377 -0.348
ENSG00000119509 E011 41.2477839 0.0005524073 7.051419e-01 0.8035599654 9 100126383 100126549 167 + 1.627 1.615 -0.041
ENSG00000119509 E012 8.4809237 0.0055515701 4.729444e-05 0.0002680565 9 100129676 100130903 1228 + 1.123 0.598 -2.053
ENSG00000119509 E013 3.2495210 0.0047224167 6.743696e-02 0.1390937519 9 100131870 100131954 85 + 0.721 0.430 -1.332
ENSG00000119509 E014 4.4224657 0.0553993516 3.926918e-01 0.5366082070 9 100214925 100215040 116 + 0.779 0.643 -0.560
ENSG00000119509 E015 7.3550238 0.0945365008 2.644802e-01 0.4024482540 9 100215401 100215488 88 + 0.978 0.814 -0.623
ENSG00000119509 E016 44.5330438 0.0005325471 1.550812e-01 0.2685159775 9 100226062 100226235 174 + 1.677 1.610 -0.229
ENSG00000119509 E017 41.3458430 0.0005714831 3.655253e-04 0.0016407847 9 100229660 100229827 168 + 1.691 1.498 -0.659
ENSG00000119509 E018 43.9427623 0.0184634346 1.966776e-01 0.3220951938 9 100240060 100240240 181 + 1.687 1.586 -0.343
ENSG00000119509 E019 33.9335468 0.0008394998 8.851314e-01 0.9305638159 9 100242570 100242679 110 + 1.542 1.542 0.000
ENSG00000119509 E020 39.5784862 0.0005449558 9.797411e-01 0.9913994961 9 100246616 100246787 172 + 1.600 1.610 0.034
ENSG00000119509 E021 37.1769614 0.0005564640 8.348981e-01 0.8966544491 9 100252283 100252438 156 + 1.581 1.577 -0.011
ENSG00000119509 E022 44.0823156 0.0005569285 2.193131e-01 0.3495440626 9 100252907 100253136 230 + 1.675 1.619 -0.191
ENSG00000119509 E023 30.3747169 0.0072837223 8.327104e-01 0.8951828287 9 100264822 100264928 107 + 1.481 1.504 0.076
ENSG00000119509 E024 50.7270836 0.0005335383 8.576126e-01 0.9120731306 9 100272864 100273076 213 + 1.710 1.710 -0.001
ENSG00000119509 E025 62.0577653 0.0007285949 3.347886e-01 0.4785252279 9 100284320 100284603 284 + 1.809 1.773 -0.119
ENSG00000119509 E026 31.0097301 0.0139317393 8.235716e-01 0.8888385958 9 100292326 100292374 49 + 1.503 1.488 -0.051
ENSG00000119509 E027 37.6155221 0.0008258256 5.704337e-01 0.6969228797 9 100292375 100292436 62 + 1.592 1.567 -0.083
ENSG00000119509 E028 63.0978567 0.0083191024 5.776586e-01 0.7028882984 9 100292437 100292873 437 + 1.786 1.826 0.137
ENSG00000119509 E029 19.2879662 0.0036294585 3.025553e-01 0.4444373734 9 100292874 100292946 73 + 1.262 1.353 0.319
ENSG00000119509 E030 37.7400726 0.0020115100 8.573600e-02 0.1685668555 9 100292947 100293043 97 + 1.539 1.648 0.374
ENSG00000119509 E031 57.9633014 0.0131778127 2.835777e-03 0.0097813248 9 100296917 100297146 230 + 1.663 1.878 0.724
ENSG00000119509 E032 37.2410056 0.0176761105 1.625536e-03 0.0060427932 9 100297936 100298010 75 + 1.444 1.715 0.922
ENSG00000119509 E033 113.5003528 0.0004140547 6.673390e-02 0.1379662501 9 100300568 100302175 1608 + 2.023 2.091 0.227