ENSG00000119487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350766 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding protein_coding 53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 7.776214 7.716527 10.689883 1.1162927 0.8052393 0.4697031 0.15074583 0.16103333 0.1846333 0.023600000 6.228867e-01 4.537856e-25 FALSE TRUE
ENST00000373498 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding protein_coding 53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 13.934078 12.087087 19.246004 1.7191105 0.8120187 0.6706487 0.26124583 0.24956667 0.3334667 0.083900000 8.653637e-04 4.537856e-25 FALSE TRUE
ENST00000420643 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding protein_coding 53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 3.707670 1.764993 2.015286 0.8830079 1.0305836 0.1903124 0.06354583 0.03333333 0.0344000 0.001066667 1.000000e+00 4.537856e-25 FALSE TRUE
ENST00000444226 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding protein_coding 53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 2.557040 1.652511 0.000000 0.8289953 0.0000000 -7.3772197 0.05257083 0.03093333 0.0000000 -0.030933333 1.051383e-01 4.537856e-25 FALSE FALSE
ENST00000496658 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding processed_transcript 53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 3.040760 10.335680 0.000000 3.6823730 0.0000000 -10.0148128 0.06424167 0.20306667 0.0000000 -0.203066667 4.537856e-25 4.537856e-25   FALSE
MSTRG.33390.12 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding   53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 5.286803 2.533755 6.455452 0.7934206 0.7397723 1.3457912 0.09572083 0.05243333 0.1115000 0.059066667 8.475588e-02 4.537856e-25 FALSE TRUE
MSTRG.33390.13 ENSG00000119487 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAP1 protein_coding   53.46233 48.46306 57.74517 6.979655 1.89523 0.252767 9.662536 5.922641 11.977976 0.5100130 0.9260309 1.0148418 0.17285417 0.12933333 0.2082333 0.078900000 2.050350e-01 4.537856e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119487 E001 0.0000000       9 125437393 125437393 1 -      
ENSG00000119487 E002 576.5502069 0.0031716086 8.383918e-01 8.989745e-01 9 125437394 125438468 1075 - 2.762 2.766 0.014
ENSG00000119487 E003 263.4827779 0.0001696446 1.925700e-02 4.989237e-02 9 125438469 125438625 157 - 2.401 2.451 0.169
ENSG00000119487 E004 137.1628327 0.0002735441 1.219761e-07 1.218905e-06 9 125438626 125438628 3 - 2.056 2.218 0.540
ENSG00000119487 E005 153.0336376 0.0002849812 5.221840e-06 3.699420e-05 9 125438629 125438654 26 - 2.121 2.253 0.441
ENSG00000119487 E006 160.7126206 0.0032586641 4.701513e-03 1.509973e-02 9 125438655 125438706 52 - 2.155 2.262 0.358
ENSG00000119487 E007 327.0810398 0.0025196789 2.817315e-04 1.305479e-03 9 125438707 125438812 106 - 2.462 2.569 0.357
ENSG00000119487 E008 510.7292762 0.0013333935 2.967042e-06 2.222496e-05 9 125438813 125439012 200 - 2.657 2.762 0.349
ENSG00000119487 E009 376.1606455 0.0001735774 1.211943e-04 6.194661e-04 9 125444501 125444598 98 - 2.546 2.616 0.236
ENSG00000119487 E010 0.1482932 0.0411597534 4.122162e-01   9 125447325 125447487 163 - 0.000 0.132 11.087
ENSG00000119487 E011 0.0000000       9 125451058 125451101 44 -      
ENSG00000119487 E012 425.4474414 0.0001449904 2.178306e-01 3.477957e-01 9 125467972 125468109 138 - 2.624 2.644 0.069
ENSG00000119487 E013 1.8540948 0.0950237127 6.116882e-01 7.307649e-01 9 125471083 125471237 155 - 0.490 0.387 -0.541
ENSG00000119487 E014 3.3160224 0.0049492278 8.800457e-02 1.720859e-01 9 125471238 125471905 668 - 0.490 0.749 1.141
ENSG00000119487 E015 1.7058162 0.0079049217 5.805238e-02 1.233012e-01 9 125478080 125478182 103 - 0.567 0.233 -1.921
ENSG00000119487 E016 418.7257684 0.0001956863 3.456756e-01 4.897961e-01 9 125484443 125484583 141 - 2.636 2.618 -0.059
ENSG00000119487 E017 1.8392339 0.0093759016 1.455436e-01 2.556090e-01 9 125505944 125506309 366 - 0.567 0.315 -1.337
ENSG00000119487 E018 176.6638192 0.0002143669 4.101501e-01 5.537622e-01 9 125506310 125506417 108 - 2.264 2.241 -0.076
ENSG00000119487 E019 1.6188433 0.0085543268 3.717031e-01 5.161704e-01 9 125521468 125521517 50 - 0.341 0.495 0.832
ENSG00000119487 E020 10.9887560 0.0016074284 7.528225e-02 1.519821e-01 9 125521518 125521644 127 - 0.985 1.161 0.638
ENSG00000119487 E021 17.9927711 0.0010241643 1.675092e-02 4.438897e-02 9 125521645 125521765 121 - 1.177 1.368 0.670
ENSG00000119487 E022 384.2576267 0.0001645253 5.004191e-01 6.366713e-01 9 125543059 125543168 110 - 2.585 2.596 0.038
ENSG00000119487 E023 0.5117019 0.0274801045 6.127190e-02 1.287821e-01 9 125559114 125559632 519 - 0.000 0.315 12.674
ENSG00000119487 E024 386.2937615 0.0001843259 6.555508e-01 7.654227e-01 9 125559633 125559782 150 - 2.598 2.589 -0.030
ENSG00000119487 E025 178.3308949 0.0008035826 4.889399e-01 6.264461e-01 9 125559783 125559809 27 - 2.269 2.247 -0.074
ENSG00000119487 E026 2.7250529 0.0098963418 4.006121e-01 5.442904e-01 9 125565366 125565737 372 - 0.490 0.623 0.613
ENSG00000119487 E027 406.9623464 0.0001209900 1.275288e-02 3.533087e-02 9 125585555 125585727 173 - 2.637 2.592 -0.148
ENSG00000119487 E028 0.6255398 0.0185402302 2.420039e-01 3.765542e-01 9 125595510 125595646 137 - 0.113 0.314 1.831
ENSG00000119487 E029 0.2903454 0.2930648491 3.385168e-01   9 125599835 125599927 93 - 0.203 0.000 -11.865
ENSG00000119487 E030 0.0000000       9 125650364 125650461 98 -      
ENSG00000119487 E031 0.2924217 0.0290785164 2.586010e-01   9 125652117 125652257 141 - 0.203 0.000 -11.869
ENSG00000119487 E032 171.8324890 0.0002086945 3.330666e-02 7.840290e-02 9 125657651 125657668 18 - 2.271 2.213 -0.194
ENSG00000119487 E033 348.7927426 0.0001791282 7.066288e-04 2.922416e-03 9 125657669 125657799 131 - 2.579 2.512 -0.222
ENSG00000119487 E034 278.6361102 0.0011247358 7.522470e-04 3.087459e-03 9 125669818 125669886 69 - 2.494 2.402 -0.307
ENSG00000119487 E035 221.5994039 0.0008894070 2.159700e-04 1.032474e-03 9 125669887 125669907 21 - 2.401 2.297 -0.345
ENSG00000119487 E036 286.2353139 0.0017653881 1.466643e-03 5.528825e-03 9 125672316 125672399 84 - 2.507 2.411 -0.319
ENSG00000119487 E037 392.8738762 0.0035263840 4.330330e-05 2.476732e-04 9 125672400 125672643 244 - 2.663 2.519 -0.481
ENSG00000119487 E038 0.2924217 0.0290785164 2.586010e-01   9 125696217 125696404 188 - 0.203 0.000 -11.869
ENSG00000119487 E039 178.2574382 0.0042983634 3.606623e-03 1.202908e-02 9 125706971 125707234 264 - 2.314 2.184 -0.433