ENSG00000119471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398803 ENSG00000119471 HEK293_OSMI2_2hA HEK293_TMG_2hB HSDL2 protein_coding protein_coding 16.12125 4.90998 24.64131 0.3905021 0.4595541 2.32494 0.5248863 0.8627270 0.0000000 0.1462929 0.0000000 -6.4474586 0.06255833 0.1754333 0.00000000 -0.1754333 6.728907e-23 6.728907e-23 FALSE TRUE
ENST00000398805 ENSG00000119471 HEK293_OSMI2_2hA HEK293_TMG_2hB HSDL2 protein_coding protein_coding 16.12125 4.90998 24.64131 0.3905021 0.4595541 2.32494 10.0103061 3.2570112 15.2953945 0.1108103 0.2111555 2.2279969 0.67360417 0.6685000 0.62130000 -0.0472000 7.047690e-01 6.728907e-23 FALSE TRUE
MSTRG.33242.1 ENSG00000119471 HEK293_OSMI2_2hA HEK293_TMG_2hB HSDL2 protein_coding   16.12125 4.90998 24.64131 0.3905021 0.4595541 2.32494 0.4306808 0.6350787 0.5866655 0.2467170 0.3149350 -0.1125528 0.05886250 0.1236000 0.02336667 -0.1002333 2.441946e-01 6.728907e-23 FALSE TRUE
MSTRG.33242.2 ENSG00000119471 HEK293_OSMI2_2hA HEK293_TMG_2hB HSDL2 protein_coding   16.12125 4.90998 24.64131 0.3905021 0.4595541 2.32494 3.7772427 0.0000000 6.9410771 0.0000000 0.8533727 9.4410927 0.14920833 0.0000000 0.28086667 0.2808667 5.479856e-18 6.728907e-23 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119471 E001 1.1856066 0.0105788193 6.082138e-01 7.280189e-01 9 112380079 112380079 1 + 0.318 0.227 -0.659
ENSG00000119471 E002 8.5800129 0.0026919856 1.497274e-01 2.613071e-01 9 112380080 112380103 24 + 0.941 0.763 -0.687
ENSG00000119471 E003 9.0249942 0.0047516780 2.157818e-01 3.453423e-01 9 112380104 112380107 4 + 0.956 0.811 -0.552
ENSG00000119471 E004 14.7333895 0.0012205192 6.223174e-02 1.303974e-01 9 112380108 112380120 13 + 1.150 0.965 -0.675
ENSG00000119471 E005 15.0321539 0.0012764380 5.081228e-02 1.106222e-01 9 112380121 112380121 1 + 1.160 0.965 -0.708
ENSG00000119471 E006 71.2361584 0.0048016357 8.784164e-02 1.718436e-01 9 112380122 112380180 59 + 1.788 1.714 -0.252
ENSG00000119471 E007 111.4127763 0.0016965684 1.033792e-04 5.376915e-04 9 112403995 112404158 164 + 1.994 1.842 -0.511
ENSG00000119471 E008 87.6827512 0.0002882044 2.764098e-02 6.729509e-02 9 112405624 112405722 99 + 1.879 1.807 -0.243
ENSG00000119471 E009 103.6111621 0.0003057398 5.583866e-04 2.378841e-03 9 112408907 112409021 115 + 1.959 1.838 -0.409
ENSG00000119471 E010 0.5848434 0.0240660447 4.438826e-01 5.854618e-01 9 112414002 112414036 35 + 0.209 0.000 -10.473
ENSG00000119471 E011 98.9183906 0.0003176169 9.138511e-06 6.129885e-05 9 112416841 112416944 104 + 1.948 1.773 -0.591
ENSG00000119471 E012 82.0235578 0.0003687164 5.977942e-02 1.262390e-01 9 112418860 112418958 99 + 1.847 1.788 -0.202
ENSG00000119471 E013 101.0294886 0.0031585907 9.599607e-01 9.788456e-01 9 112438431 112438625 195 + 1.919 1.944 0.086
ENSG00000119471 E014 0.5806908 0.8010173084 1.000000e+00 1.000000e+00 9 112438743 112438812 70 + 0.207 0.000 -9.202
ENSG00000119471 E015 69.2826944 0.0141075838 9.919589e-01 9.990836e-01 9 112441699 112441770 72 + 1.758 1.775 0.056
ENSG00000119471 E016 125.9815788 0.0004212268 6.801912e-01 7.841407e-01 9 112454013 112454162 150 + 2.015 2.030 0.051
ENSG00000119471 E017 151.5479764 0.0002827769 7.450052e-02 1.507396e-01 9 112459449 112459577 129 + 2.104 2.073 -0.105
ENSG00000119471 E018 396.3720089 0.0002149610 3.234368e-01 4.667676e-01 9 112470432 112471646 1215 + 2.503 2.554 0.169
ENSG00000119471 E019 155.5870202 0.0017961390 1.214958e-07 1.214554e-06 9 112471647 112472071 425 + 2.057 2.278 0.741
ENSG00000119471 E020 131.2084599 0.0275845028 2.583715e-04 1.210019e-03 9 112472072 112472405 334 + 1.936 2.288 1.180
ENSG00000119471 E021 0.0000000       9 112475856 112475900 45 +