ENSG00000119431

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238379 ENSG00000119431 HEK293_OSMI2_2hA HEK293_TMG_2hB HDHD3 protein_coding protein_coding 33.73107 61.42518 18.371 2.729831 0.3064799 -1.740849 7.771406 10.71011 6.096483 0.6931107 0.4959195 -0.8119062 0.2664167 0.1745667 0.3312667 0.15670000 1.635954e-05 1.635954e-05 FALSE TRUE
ENST00000374180 ENSG00000119431 HEK293_OSMI2_2hA HEK293_TMG_2hB HDHD3 protein_coding protein_coding 33.73107 61.42518 18.371 2.729831 0.3064799 -1.740849 18.548148 38.63707 7.539170 1.4933067 0.6347516 -2.3559692 0.5082375 0.6293333 0.4109667 -0.21836667 1.119077e-04 1.635954e-05 FALSE TRUE
ENST00000485934 ENSG00000119431 HEK293_OSMI2_2hA HEK293_TMG_2hB HDHD3 protein_coding processed_transcript 33.73107 61.42518 18.371 2.729831 0.3064799 -1.740849 7.369142 12.07799 4.735352 1.0584891 0.3586724 -1.3489878 0.2238000 0.1961000 0.2577667 0.06166667 1.627904e-01 1.635954e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119431 E001 1.773452 0.2374518250 9.537832e-01 9.750488e-01 9 113373419 113373421 3 - 0.353 0.373 0.118
ENSG00000119431 E002 379.139055 0.0002109747 1.508827e-11 3.051918e-10 9 113373422 113373756 335 - 2.330 2.490 0.534
ENSG00000119431 E003 393.260325 0.0001810988 1.049310e-03 4.130073e-03 9 113373757 113373887 131 - 2.422 2.493 0.238
ENSG00000119431 E004 365.322951 0.0004444937 3.683325e-01 5.127531e-01 9 113373888 113373989 102 - 2.433 2.453 0.066
ENSG00000119431 E005 673.377669 0.0002819887 4.805569e-02 1.057278e-01 9 113373990 113374383 394 - 2.689 2.720 0.104
ENSG00000119431 E006 406.214591 0.0002119627 7.117970e-01 8.086859e-01 9 113374384 113374529 146 - 2.503 2.493 -0.033
ENSG00000119431 E007 238.588251 0.0016382562 8.562078e-02 1.683875e-01 9 113375453 113375526 74 - 2.311 2.253 -0.191
ENSG00000119431 E008 98.525122 0.0003443137 2.448263e-02 6.081957e-02 9 113375527 113375567 41 - 1.961 1.864 -0.328
ENSG00000119431 E009 74.154549 0.0015457687 2.203322e-09 3.063131e-08 9 113375568 113375680 113 - 1.984 1.698 -0.965
ENSG00000119431 E010 127.209544 0.0002525188 1.026379e-21 7.897820e-20 9 113375681 113376175 495 - 2.240 1.913 -1.095
ENSG00000119431 E011 217.661457 0.0046047739 5.327232e-01 6.650378e-01 9 113376729 113376986 258 - 2.246 2.220 -0.088