ENSG00000119414

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373547 ENSG00000119414 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6C protein_coding protein_coding 55.82252 54.71345 61.14518 3.083506 0.8275686 0.1603155 15.179205 14.896485 19.620023 2.0865592 0.9212762 0.39712173 0.26747917 0.27000000 0.32093333 0.05093333 0.42926574 0.00164898 FALSE TRUE
MSTRG.33378.4 ENSG00000119414 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6C protein_coding   55.82252 54.71345 61.14518 3.083506 0.8275686 0.1603155 33.922062 35.858578 33.853976 1.1674825 0.6697943 -0.08296921 0.61348750 0.65713333 0.55356667 -0.10356667 0.00164898 0.00164898 FALSE TRUE
MSTRG.33378.5 ENSG00000119414 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6C protein_coding   55.82252 54.71345 61.14518 3.083506 0.8275686 0.1603155 3.365337 1.350427 5.123212 0.4157476 1.1267980 1.91580173 0.05995417 0.02506667 0.08396667 0.05890000 0.02023692 0.00164898   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119414 E001 0.3299976 0.0274424043 1.978457e-01   9 125146573 125146573 1 - 0.000 0.216 9.234
ENSG00000119414 E002 1013.8942880 0.0090922147 6.907561e-01 7.923566e-01 9 125146574 125149383 2810 - 3.017 2.995 -0.074
ENSG00000119414 E003 1252.9177386 0.0001957209 1.504596e-53 1.131116e-50 9 125149384 125149921 538 - 3.009 3.162 0.508
ENSG00000119414 E004 10.7027773 0.0345983125 1.404334e-04 7.054328e-04 9 125150688 125150766 79 - 1.279 0.743 -1.990
ENSG00000119414 E005 864.9786092 0.0003559275 9.798826e-01 9.914643e-01 9 125153533 125153742 210 - 2.944 2.933 -0.036
ENSG00000119414 E006 479.3312320 0.0001441642 3.725585e-02 8.596215e-02 9 125153906 125153953 48 - 2.706 2.662 -0.145
ENSG00000119414 E007 423.2637007 0.0003666118 1.083800e-01 2.031429e-01 9 125153954 125153985 32 - 2.649 2.608 -0.136
ENSG00000119414 E008 677.4840484 0.0013438340 3.166365e-02 7.519473e-02 9 125158241 125158382 142 - 2.862 2.803 -0.197
ENSG00000119414 E009 412.9651441 0.0024753997 2.386731e-02 5.953299e-02 9 125160841 125160906 66 - 2.658 2.577 -0.269
ENSG00000119414 E010 476.1088999 0.0013685651 1.498830e-07 1.471466e-06 9 125171085 125171180 96 - 2.747 2.612 -0.449
ENSG00000119414 E011 5.5939305 0.0031410790 8.696400e-02 1.705348e-01 9 125171909 125172001 93 - 0.693 0.908 0.852
ENSG00000119414 E012 4.5641850 0.0036326751 9.872713e-01 9.960946e-01 9 125188919 125188947 29 - 0.747 0.742 -0.022
ENSG00000119414 E013 5.2263582 0.0030303440 9.850175e-01 9.946539e-01 9 125189562 125189643 82 - 0.796 0.790 -0.022
ENSG00000119414 E014 319.1097961 0.0026254106 7.992350e-06 5.428923e-05 9 125189644 125189939 296 - 2.581 2.428 -0.512