ENSG00000119402

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000608872 ENSG00000119402 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW2 protein_coding protein_coding 20.25411 16.31266 23.94074 1.804896 0.3809972 0.5531938 1.305840 1.6698001 1.461808 0.2914169 0.1325558 -0.1907003 0.06697917 0.10090000 0.06093333 -0.03996667 2.838890e-02 3.892126e-15 FALSE TRUE
MSTRG.33298.12 ENSG00000119402 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW2 protein_coding   20.25411 16.31266 23.94074 1.804896 0.3809972 0.5531938 1.233279 0.7347661 1.548778 0.2513717 0.1956468 1.0655565 0.05882917 0.04810000 0.06473333 0.01663333 7.010509e-01 3.892126e-15 FALSE TRUE
MSTRG.33298.13 ENSG00000119402 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW2 protein_coding   20.25411 16.31266 23.94074 1.804896 0.3809972 0.5531938 8.642210 9.5672578 8.449681 1.2361401 0.2585051 -0.1790093 0.43827500 0.58376667 0.35286667 -0.23090000 4.682937e-13 3.892126e-15 FALSE TRUE
MSTRG.33298.7 ENSG00000119402 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW2 protein_coding   20.25411 16.31266 23.94074 1.804896 0.3809972 0.5531938 1.984319 1.7483699 2.117057 0.3213259 0.3827161 0.2746201 0.09993750 0.10620000 0.08853333 -0.01766667 7.360058e-01 3.892126e-15 FALSE TRUE
MSTRG.33298.8 ENSG00000119402 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW2 protein_coding   20.25411 16.31266 23.94074 1.804896 0.3809972 0.5531938 4.353529 1.0806062 6.861057 0.1082346 0.3366476 2.6554018 0.20154583 0.06773333 0.28653333 0.21880000 3.892126e-15 3.892126e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119402 E001 2.8098608 0.0937213183 9.795071e-01 9.912325e-01 9 120751978 120753059 1082 - 0.577 0.569 -0.035
ENSG00000119402 E002 0.1451727 0.0432793145 6.701215e-01   9 120753060 120753114 55 - 0.106 0.000 -9.679
ENSG00000119402 E003 0.7363589 0.0155883616 3.972442e-02 9.051263e-02 9 120753115 120753311 197 - 0.377 0.000 -12.001
ENSG00000119402 E004 30.4726520 0.0006702512 1.114183e-05 7.323274e-05 9 120756974 120757719 746 - 1.354 1.634 0.962
ENSG00000119402 E005 249.7436566 0.0035941208 1.904421e-05 1.187072e-04 9 120757720 120759686 1967 - 2.324 2.480 0.519
ENSG00000119402 E006 582.8088791 0.0020718324 4.597096e-02 1.019784e-01 9 120759687 120761756 2070 - 2.789 2.744 -0.148
ENSG00000119402 E007 150.5485123 0.0026194699 4.381760e-12 9.664820e-11 9 120761757 120762431 675 - 2.286 2.020 -0.889
ENSG00000119402 E008 214.0025927 0.0004006201 2.460486e-38 7.654050e-36 9 120762432 120763463 1032 - 2.461 2.122 -1.132
ENSG00000119402 E009 297.4728376 0.0001820685 1.329845e-14 4.301437e-13 9 120763464 120764511 1048 - 2.543 2.388 -0.517
ENSG00000119402 E010 332.0493801 0.0002137641 7.335035e-14 2.125421e-12 9 120764512 120764847 336 - 2.453 2.602 0.496
ENSG00000119402 E011 230.0417202 0.0017385942 3.094919e-07 2.855099e-06 9 120771348 120771517 170 - 2.290 2.444 0.516
ENSG00000119402 E012 151.9526490 0.0004896061 1.358814e-06 1.096675e-05 9 120772754 120772840 87 - 2.114 2.260 0.489
ENSG00000119402 E013 216.1050359 0.0014458138 1.111426e-02 3.143851e-02 9 120776093 120776226 134 - 2.303 2.378 0.249
ENSG00000119402 E014 15.4061013 0.0143008122 1.981961e-01 3.239492e-01 9 120776227 120776655 429 - 1.155 1.291 0.481
ENSG00000119402 E015 9.9088640 0.0022992284 9.431307e-01 9.683402e-01 9 120776931 120777021 91 - 1.029 1.039 0.039
ENSG00000119402 E016 243.1455084 0.0001820567 1.402351e-01 2.483395e-01 9 120778351 120778545 195 - 2.373 2.411 0.125
ENSG00000119402 E017 338.7846154 0.0002127080 7.586014e-01 8.431571e-01 9 120787769 120788186 418 - 2.535 2.533 -0.007
ENSG00000119402 E018 64.6604130 0.0032948744 5.743322e-01 7.001523e-01 9 120788187 120788278 92 - 1.831 1.801 -0.099
ENSG00000119402 E019 15.1750317 0.0106051287 1.593243e-01 2.742138e-01 9 120792887 120793015 129 - 1.266 1.123 -0.505
ENSG00000119402 E020 10.5041792 0.0018565286 2.300004e-01 3.624641e-01 9 120793016 120793148 133 - 1.111 0.991 -0.435
ENSG00000119402 E021 60.0558899 0.0112275426 3.098995e-01 4.522484e-01 9 120793149 120793257 109 - 1.755 1.817 0.210
ENSG00000119402 E022 6.4183191 0.0542412601 6.603471e-01 7.690248e-01 9 120793258 120793353 96 - 0.834 0.900 0.253
ENSG00000119402 E023 11.1912915 0.0122794853 5.173001e-01 6.517163e-01 9 120793354 120793359 6 - 1.051 1.122 0.259
ENSG00000119402 E024 22.6231611 0.0119814690 8.098740e-01 8.793394e-01 9 120793360 120793441 82 - 1.364 1.386 0.074