ENSG00000119392

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309971 ENSG00000119392 HEK293_OSMI2_2hA HEK293_TMG_2hB GLE1 protein_coding protein_coding 32.56463 31.50211 33.68449 2.965538 0.2490566 0.09660639 6.296481 11.249618 3.091206 2.428495 0.3980332 -1.86025683 0.1978833 0.3583000 0.09183333 -0.26646667 0.0001599920 0.000159992 FALSE TRUE
ENST00000372770 ENSG00000119392 HEK293_OSMI2_2hA HEK293_TMG_2hB GLE1 protein_coding protein_coding 32.56463 31.50211 33.68449 2.965538 0.2490566 0.09660639 11.020809 5.481973 15.931054 1.559215 0.2251765 1.53735056 0.3330750 0.1752333 0.47290000 0.29766667 0.0008695829 0.000159992 FALSE TRUE
ENST00000683288 ENSG00000119392 HEK293_OSMI2_2hA HEK293_TMG_2hB GLE1 protein_coding nonsense_mediated_decay 32.56463 31.50211 33.68449 2.965538 0.2490566 0.09660639 12.797657 12.863502 12.102596 1.881882 0.5482276 -0.08789648 0.3936625 0.4047333 0.35920000 -0.04553333 0.6036335188 0.000159992 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119392 E001 0.2944980 0.3359695763 2.225809e-01   9 128504655 128504696 42 + 0.229 0.000 -12.363
ENSG00000119392 E002 0.4762024 0.1834634373 5.004715e-01 6.367250e-01 9 128504697 128504699 3 + 0.229 0.116 -1.177
ENSG00000119392 E003 0.6244956 0.0347906572 8.175144e-01 8.846231e-01 9 128504700 128504701 2 + 0.229 0.207 -0.183
ENSG00000119392 E004 3.5291555 0.0048044859 4.465782e-03 1.444500e-02 9 128504702 128504718 17 + 0.838 0.452 -1.684
ENSG00000119392 E005 6.1495972 0.0086765176 1.752770e-03 6.449088e-03 9 128504719 128504725 7 + 1.029 0.668 -1.406
ENSG00000119392 E006 8.9559210 0.0311522506 1.653763e-02 4.392268e-02 9 128504726 128504730 5 + 1.140 0.866 -1.015
ENSG00000119392 E007 17.5605150 0.0010393144 1.727584e-05 1.087219e-04 9 128504731 128504736 6 + 1.420 1.121 -1.050
ENSG00000119392 E008 55.7381166 0.0004334622 2.394347e-06 1.831181e-05 9 128504737 128504767 31 + 1.845 1.670 -0.590
ENSG00000119392 E009 162.8852958 0.0002386870 1.194028e-09 1.743660e-08 9 128504768 128504904 137 + 2.282 2.161 -0.407
ENSG00000119392 E010 89.0649058 0.0005236240 7.834416e-03 2.336589e-02 9 128507216 128507340 125 + 1.987 1.932 -0.183
ENSG00000119392 E011 181.3071514 0.0002012446 5.326858e-11 9.843756e-10 9 128508876 128508959 84 + 2.329 2.203 -0.420
ENSG00000119392 E012 319.9905905 0.0001368512 8.654513e-23 7.503760e-21 9 128508960 128509097 138 + 2.585 2.438 -0.489
ENSG00000119392 E013 327.2009358 0.0001569059 1.122041e-17 5.471488e-16 9 128515529 128515639 111 + 2.582 2.461 -0.404
ENSG00000119392 E014 6.7227266 0.0032319660 1.381076e-01 2.454392e-01 9 128515640 128516414 775 + 0.741 0.966 0.873
ENSG00000119392 E015 4.1087109 0.0205700314 1.070974e-01 2.012507e-01 9 128520148 128522667 2520 + 0.816 0.608 -0.859
ENSG00000119392 E016 392.3113086 0.0005071743 8.736146e-08 8.969416e-07 9 128522668 128522816 149 + 2.630 2.568 -0.206
ENSG00000119392 E017 0.8491631 0.0161344712 4.872986e-01 6.249772e-01 9 128522981 128523002 22 + 0.310 0.207 -0.764
ENSG00000119392 E018 1.4737724 0.0095760313 5.015844e-01 6.377213e-01 9 128523003 128523279 277 + 0.437 0.347 -0.503
ENSG00000119392 E019 238.3103101 0.0003065915 1.782508e-01 2.989579e-01 9 128523280 128523340 61 + 2.371 2.385 0.047
ENSG00000119392 E020 0.9588482 0.0130492711 2.740553e-01 4.131570e-01 9 128523341 128523591 251 + 0.378 0.207 -1.181
ENSG00000119392 E021 379.1988202 0.0012436476 9.295819e-01 9.596597e-01 9 128523592 128523846 255 + 2.554 2.595 0.135
ENSG00000119392 E022 116.8603251 0.0002767173 6.401624e-01 7.534548e-01 9 128525192 128525196 5 + 2.036 2.099 0.209
ENSG00000119392 E023 326.9039528 0.0002689649 2.130844e-01 3.421788e-01 9 128525197 128525423 227 + 2.472 2.544 0.239
ENSG00000119392 E024 0.0000000       9 128525424 128525776 353 +      
ENSG00000119392 E025 219.5636718 0.0002456813 2.935918e-01 4.346729e-01 9 128527179 128527291 113 + 2.299 2.371 0.241
ENSG00000119392 E026 207.7879841 0.0028252277 6.617087e-01 7.701397e-01 9 128527456 128527525 70 + 2.302 2.325 0.078
ENSG00000119392 E027 0.5975289 0.0286754657 2.266535e-02 5.705853e-02 9 128528789 128529099 311 + 0.378 0.000 -13.426
ENSG00000119392 E028 1.6357821 0.1437347788 8.460044e-01 9.042608e-01 9 128532665 128532691 27 + 0.378 0.450 0.386
ENSG00000119392 E029 296.5998050 0.0045162369 8.018637e-01 8.737579e-01 9 128533513 128533655 143 + 2.453 2.480 0.090
ENSG00000119392 E030 363.3571362 0.0013965261 4.733451e-01 6.122949e-01 9 128533761 128533951 191 + 2.545 2.568 0.076
ENSG00000119392 E031 6.9179011 0.0590147812 9.453185e-01 9.696773e-01 9 128536071 128536354 284 + 0.881 0.892 0.042
ENSG00000119392 E032 316.0928006 0.0003823545 9.331306e-01 9.618496e-01 9 128536355 128536484 130 + 2.472 2.519 0.157
ENSG00000119392 E033 299.2319559 0.0001654387 5.775491e-01 7.027844e-01 9 128537986 128538090 105 + 2.457 2.492 0.118
ENSG00000119392 E034 247.6379209 0.0001767677 3.226117e-01 4.659259e-01 9 128539616 128539698 83 + 2.355 2.425 0.232
ENSG00000119392 E035 6.7384428 0.0024974475 1.555077e-03 5.813953e-03 9 128539699 128539877 179 + 0.577 1.032 1.818
ENSG00000119392 E036 233.9851575 0.0002090878 4.450968e-01 5.866467e-01 9 128540275 128540338 64 + 2.333 2.399 0.217
ENSG00000119392 E037 5.6762456 0.0187458462 4.220753e-01 5.652385e-01 9 128540339 128541101 763 + 0.741 0.900 0.626
ENSG00000119392 E038 1616.9653987 0.0038068379 3.656714e-11 6.937942e-10 9 128541102 128543874 2773 + 3.073 3.280 0.688