ENSG00000119335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322030 ENSG00000119335 HEK293_OSMI2_2hA HEK293_TMG_2hB SET protein_coding protein_coding 354.1129 267.1433 538.397 31.29612 21.28563 1.011029 126.30612 70.434496 222.47851 1.829673 3.518950 1.6591719 0.34476250 0.269500000 0.4140000 0.14450000 2.910948e-03 6.046051e-08 FALSE TRUE
ENST00000372686 ENSG00000119335 HEK293_OSMI2_2hA HEK293_TMG_2hB SET protein_coding protein_coding 354.1129 267.1433 538.397 31.29612 21.28563 1.011029 113.74037 146.301282 107.41624 28.172739 17.259598 -0.4456946 0.36754583 0.538766667 0.1977667 -0.34100000 5.997407e-07 6.046051e-08 FALSE TRUE
ENST00000477806 ENSG00000119335 HEK293_OSMI2_2hA HEK293_TMG_2hB SET protein_coding processed_transcript 354.1129 267.1433 538.397 31.29612 21.28563 1.011029 35.09162 0.871657 72.87116 0.554288 1.672993 6.3691846 0.07699583 0.003433333 0.1356000 0.13216667 6.046051e-08 6.046051e-08   FALSE
ENST00000686840 ENSG00000119335 HEK293_OSMI2_2hA HEK293_TMG_2hB SET protein_coding protein_coding 354.1129 267.1433 538.397 31.29612 21.28563 1.011029 64.53946 42.022088 113.88278 1.103110 6.221648 1.4381133 0.16926667 0.160600000 0.2123333 0.05173333 2.269473e-01 6.046051e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119335 E001 0.000000e+00       9 128683104 128683328 225 +      
ENSG00000119335 E002 0.000000e+00       9 128683329 128683377 49 +      
ENSG00000119335 E003 0.000000e+00       9 128683378 128683423 46 +      
ENSG00000119335 E004 7.363589e-01 0.0155730306 6.553078e-02 1.359237e-01 9 128683424 128683436 13 + 0.340 0.000 -11.113
ENSG00000119335 E005 3.991074e+00 0.0040696794 6.086061e-01 7.282953e-01 9 128683437 128683446 10 + 0.702 0.660 -0.174
ENSG00000119335 E006 3.030308e-01 0.3932638324 5.165961e-01   9 128683447 128683513 67 + 0.169 0.000 -9.791
ENSG00000119335 E007 1.314858e+01 0.0026366797 5.094050e-03 1.618781e-02 9 128683655 128683779 125 + 1.221 0.977 -0.883
ENSG00000119335 E008 6.325862e+01 0.0015209463 9.465885e-05 4.969472e-04 9 128683780 128683829 50 + 1.852 1.696 -0.528
ENSG00000119335 E009 5.969168e+01 0.0031433359 4.766748e-04 2.070827e-03 9 128683830 128683830 1 + 1.827 1.672 -0.524
ENSG00000119335 E010 4.306141e+02 0.0037849420 1.229840e-04 6.275642e-04 9 128683831 128684007 177 + 2.663 2.560 -0.340
ENSG00000119335 E011 2.924217e-01 0.0273868000 3.993125e-01   9 128684008 128684011 4 + 0.169 0.000 -9.783
ENSG00000119335 E012 4.720498e-01 0.2111344510 1.000000e+00 1.000000e+00 9 128685083 128685213 131 + 0.168 0.161 -0.080
ENSG00000119335 E013 1.211031e+01 0.0014702027 7.727328e-05 4.151548e-04 9 128689222 128689229 8 + 1.221 0.833 -1.431
ENSG00000119335 E014 2.777065e+01 0.0006878123 1.536196e-09 2.200422e-08 9 128689230 128689234 5 + 1.571 1.158 -1.438
ENSG00000119335 E015 4.962243e+02 0.0052459336 8.117727e-15 2.706581e-13 9 128689235 128689537 303 + 2.776 2.494 -0.938
ENSG00000119335 E016 1.104076e+03 0.0019533071 6.492777e-08 6.839619e-07 9 128689538 128689655 118 + 3.069 2.972 -0.322
ENSG00000119335 E017 6.194966e+00 0.0026709983 5.258826e-02 1.137683e-01 9 128689975 128690026 52 + 0.922 0.701 -0.871
ENSG00000119335 E018 3.264371e+00 0.0060419894 4.604401e-03 1.483234e-02 9 128690250 128690280 31 + 0.741 0.277 -2.334
ENSG00000119335 E019 3.597591e+00 0.0077899554 1.223932e-02 3.410859e-02 9 128690281 128690284 4 + 0.759 0.369 -1.822
ENSG00000119335 E020 8.654923e+00 0.0020360400 1.335174e-02 3.673960e-02 9 128690285 128690353 69 + 1.058 0.803 -0.962
ENSG00000119335 E021 1.093155e+01 0.0154224307 4.045926e-02 9.186765e-02 9 128690354 128690439 86 + 1.140 0.933 -0.758
ENSG00000119335 E022 2.015496e+01 0.0025481871 4.561247e-04 1.990910e-03 9 128690440 128690544 105 + 1.401 1.144 -0.903
ENSG00000119335 E023 3.222423e+01 0.0016225403 9.427273e-03 2.734895e-02 9 128690545 128690727 183 + 1.560 1.430 -0.449
ENSG00000119335 E024 4.416401e+01 0.0023942584 5.373520e-01 6.689252e-01 9 128690728 128691169 442 + 1.645 1.650 0.017
ENSG00000119335 E025 1.165391e+03 0.0008105411 5.023110e-09 6.554260e-08 9 128691170 128691175 6 + 3.082 3.016 -0.219
ENSG00000119335 E026 1.730224e+03 0.0004639589 2.756334e-16 1.123933e-14 9 128691176 128691227 52 + 3.257 3.183 -0.243
ENSG00000119335 E027 3.339521e+01 0.0006364135 1.172424e-05 7.668033e-05 9 128691241 128691857 617 + 1.606 1.360 -0.847
ENSG00000119335 E028 3.091341e+03 0.0012345103 3.956232e-07 3.569880e-06 9 128691858 128692000 143 + 3.502 3.445 -0.187
ENSG00000119335 E029 1.051158e+01 0.0016004509 6.535691e-01 7.639988e-01 9 128692351 128692661 311 + 1.058 1.052 -0.023
ENSG00000119335 E030 3.116829e+03 0.0014295726 9.828362e-02 1.879167e-01 9 128692662 128692765 104 + 3.483 3.485 0.005
ENSG00000119335 E031 3.492990e+03 0.0022333197 1.580668e-01 2.725444e-01 9 128692868 128692981 114 + 3.533 3.533 -0.002
ENSG00000119335 E032 6.154516e+03 0.0006077846 3.757330e-07 3.405324e-06 9 128693638 128693808 171 + 3.789 3.764 -0.083
ENSG00000119335 E033 5.383421e+03 0.0001305254 2.199855e-11 4.334435e-10 9 128693896 128694001 106 + 3.725 3.718 -0.023
ENSG00000119335 E034 3.136379e+03 0.0002994485 4.709444e-02 1.039933e-01 9 128694002 128694042 41 + 3.464 3.524 0.199
ENSG00000119335 E035 3.444492e+01 0.0006048555 5.063613e-01 6.420214e-01 9 128694043 128694640 598 + 1.546 1.549 0.009
ENSG00000119335 E036 2.000008e+03 0.0000686997 5.959554e-09 7.676228e-08 9 128694641 128694643 3 + 3.256 3.349 0.311
ENSG00000119335 E037 2.044880e+03 0.0023991530 6.762535e-03 2.060675e-02 9 128694644 128694650 7 + 3.257 3.362 0.348
ENSG00000119335 E038 1.363720e+04 0.0033237245 3.283783e-07 3.013480e-06 9 128694651 128696400 1750 + 4.062 4.207 0.481