ENSG00000119326

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325551 ENSG00000119326 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNAL1 protein_coding protein_coding 28.49282 9.071021 51.34208 1.281363 1.599605 2.499496 26.765839 6.558354 50.32434 0.6269101 1.368717 2.937939 0.8593417 0.7542000 0.9804333 0.2262333 0.006985992 0.006985992 FALSE TRUE
ENST00000374594 ENSG00000119326 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNAL1 protein_coding protein_coding 28.49282 9.071021 51.34208 1.281363 1.599605 2.499496 1.151921 2.185072 0.00000 1.6933161 0.000000 -7.778125 0.1159167 0.2071333 0.0000000 -0.2071333 0.058924835 0.006985992 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119326 E001 0.2987644 0.0274828355 1.000000e+00   9 108942569 108942576 8 - 0.104 0.000 -8.429
ENSG00000119326 E002 0.4470576 0.0216338723 4.134286e-01 5.569193e-01 9 108942577 108942578 2 - 0.104 0.250 1.523
ENSG00000119326 E003 3.3998734 0.0137777563 2.361602e-03 8.342937e-03 9 108942579 108942602 24 - 0.397 0.906 2.241
ENSG00000119326 E004 200.4463330 0.0123288058 7.679524e-05 4.129088e-04 9 108942603 108942834 232 - 2.126 2.393 0.890
ENSG00000119326 E005 4.9414887 0.0035588503 4.892392e-03 1.563089e-02 9 108942835 108942871 37 - 0.554 0.982 1.738
ENSG00000119326 E006 192.6257955 0.0164055320 1.321712e-02 3.641677e-02 9 108942961 108943044 84 - 2.125 2.330 0.683
ENSG00000119326 E007 218.8805739 0.0005684687 7.051047e-11 1.276201e-09 9 108943703 108943816 114 - 2.177 2.394 0.722
ENSG00000119326 E008 143.6961574 0.0002338217 1.187161e-06 9.703762e-06 9 108943962 108944018 57 - 2.000 2.194 0.650
ENSG00000119326 E009 114.2949678 0.0008203710 2.979453e-04 1.371204e-03 9 108948186 108948234 49 - 1.906 2.078 0.579
ENSG00000119326 E010 214.0928365 0.0002731856 1.456467e-04 7.284144e-04 9 108952209 108952360 152 - 2.186 2.321 0.452
ENSG00000119326 E011 91.8930668 0.0002880241 8.305744e-03 2.455943e-02 9 108952361 108952363 3 - 1.821 1.962 0.473
ENSG00000119326 E012 184.0703571 0.0004687241 5.301318e-03 1.675121e-02 9 108952444 108952494 51 - 2.126 2.239 0.379
ENSG00000119326 E013 171.0879223 0.0002349060 7.066523e-02 1.444435e-01 9 108955790 108955827 38 - 2.101 2.183 0.276
ENSG00000119326 E014 0.2924217 0.0271466354 1.000000e+00   9 108963498 108963555 58 - 0.104 0.000 -8.419
ENSG00000119326 E015 277.6485092 0.0001580700 1.089255e-01 2.039455e-01 9 108965378 108965528 151 - 2.312 2.376 0.212
ENSG00000119326 E016 203.8387678 0.0017224941 7.466045e-01 8.343073e-01 9 108970402 108970494 93 - 2.189 2.195 0.022
ENSG00000119326 E017 213.5545166 0.0002111682 3.821977e-01 5.264260e-01 9 108972675 108972833 159 - 2.211 2.203 -0.028
ENSG00000119326 E018 198.6103147 0.0002120631 9.003237e-04 3.614914e-03 9 108976962 108977048 87 - 2.194 2.097 -0.324
ENSG00000119326 E019 0.1451727 0.0429131670 1.000000e+00   9 108977049 108977420 372 - 0.055 0.000 -7.419
ENSG00000119326 E020 270.9397468 0.0008246801 2.729722e-05 1.639911e-04 9 108979281 108979481 201 - 2.331 2.214 -0.393
ENSG00000119326 E021 236.9283824 0.0007591586 4.496935e-06 3.235590e-05 9 108983145 108983315 171 - 2.277 2.136 -0.471
ENSG00000119326 E022 193.5844388 0.0001861290 1.602071e-09 2.286654e-08 9 108984347 108984436 90 - 2.198 1.990 -0.695
ENSG00000119326 E023 216.8814933 0.0001989411 2.112812e-11 4.170306e-10 9 108990726 108990845 120 - 2.248 2.027 -0.740
ENSG00000119326 E024 0.0000000       9 108991896 108992067 172 -      
ENSG00000119326 E025 254.6762020 0.0001834001 1.847470e-14 5.852804e-13 9 108992632 108992819 188 - 2.320 2.084 -0.789
ENSG00000119326 E026 189.1149434 0.0002210330 2.181161e-10 3.627551e-09 9 108999067 108999256 190 - 2.191 1.965 -0.755
ENSG00000119326 E027 125.8036429 0.0036597402 1.872454e-03 6.830415e-03 9 109013302 109013522 221 - 2.004 1.855 -0.503