ENSG00000119318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358015 ENSG00000119318 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23B protein_coding protein_coding 58.2002 41.26359 90.14298 4.225256 0.6207917 1.127156 52.038983 28.74946 81.3609952 2.697690 2.68615424 1.500478 0.8891625 0.7175667 0.9028333 0.1852667 4.014434e-01 5.342781e-12 FALSE TRUE
ENST00000416373 ENSG00000119318 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23B protein_coding protein_coding 58.2002 41.26359 90.14298 4.225256 0.6207917 1.127156 2.992136 12.38618 0.1470332 6.223784 0.07826758 -6.302682 0.0724750 0.2791333 0.0016000 -0.2775333 8.752108e-05 5.342781e-12 FALSE TRUE
ENST00000419616 ENSG00000119318 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23B protein_coding protein_coding 58.2002 41.26359 90.14298 4.225256 0.6207917 1.127156 3.056149 0.00000 8.4233292 0.000000 2.99416382 9.719958 0.0360000 0.0000000 0.0932000 0.0932000 5.342781e-12 5.342781e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119318 E001 0.9620705 1.219891e-02 3.371448e-01 4.810075e-01 9 107282929 107283136 208 + 0.327 0.168 -1.257
ENSG00000119318 E002 54.7133103 1.175753e-02 1.401126e-02 3.825212e-02 9 107283137 107283278 142 + 1.778 1.629 -0.507
ENSG00000119318 E003 146.1110830 1.815625e-02 2.223943e-03 7.917602e-03 9 107283279 107283309 31 + 2.213 2.016 -0.660
ENSG00000119318 E004 259.5258599 3.632654e-02 4.270898e-03 1.390197e-02 9 107283310 107283526 217 + 2.474 2.231 -0.810
ENSG00000119318 E005 334.1439447 6.152330e-03 6.869921e-09 8.730703e-08 9 107283527 107283695 169 + 2.579 2.357 -0.738
ENSG00000119318 E006 0.2924217 2.728810e-02 4.487986e-01   9 107284053 107284187 135 + 0.161 0.000 -9.303
ENSG00000119318 E007 0.1451727 4.353739e-02 1.000000e+00   9 107284695 107284913 219 + 0.088 0.000 -8.303
ENSG00000119318 E008 366.2006503 2.540788e-03 5.241809e-06 3.712318e-05 9 107300141 107300222 82 + 2.586 2.480 -0.354
ENSG00000119318 E009 470.5643799 1.449632e-04 6.689023e-06 4.628082e-05 9 107302035 107302114 80 + 2.673 2.637 -0.123
ENSG00000119318 E010 856.9989498 1.067409e-04 3.121401e-11 5.991288e-10 9 107306379 107306541 163 + 2.936 2.892 -0.147
ENSG00000119318 E011 853.4762204 1.084613e-04 9.750237e-12 2.035206e-10 9 107306542 107306647 106 + 2.935 2.888 -0.155
ENSG00000119318 E012 643.9181977 1.302119e-04 6.804782e-10 1.041397e-08 9 107311682 107311737 56 + 2.814 2.763 -0.170
ENSG00000119318 E013 873.9626273 8.990457e-05 4.923745e-04 2.131114e-03 9 107318752 107318879 128 + 2.929 2.927 -0.006
ENSG00000119318 E014 853.8995673 1.231760e-04 1.158724e-02 3.255475e-02 9 107321983 107322118 136 + 2.915 2.924 0.031
ENSG00000119318 E015 884.3862522 9.547773e-04 5.079156e-03 1.614671e-02 9 107323890 107324017 128 + 2.938 2.924 -0.044
ENSG00000119318 E016 1269.2480533 8.405876e-05 6.508647e-02 1.351725e-01 9 107324834 107325004 171 + 3.067 3.129 0.206
ENSG00000119318 E017 3322.3738873 2.085511e-03 2.907155e-19 1.706699e-17 9 107329543 107331668 2126 + 3.427 3.616 0.628
ENSG00000119318 E018 134.0576016 5.328328e-03 8.000132e-09 1.004308e-07 9 107331669 107332192 524 + 1.974 2.295 1.075