ENSG00000119314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000210227 ENSG00000119314 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP3 protein_coding protein_coding 10.19785 3.1274 19.38935 0.3670383 0.3053166 2.628367 0.4929232 0.000000000 1.108614 0.000000000 0.2588875 6.805568 0.02775833 0.0000000 0.05703333 0.05703333 5.095003e-04 3.00149e-05 FALSE FALSE
ENST00000374257 ENSG00000119314 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP3 protein_coding protein_coding 10.19785 3.1274 19.38935 0.3670383 0.3053166 2.628367 8.0469580 2.992463981 14.314655 0.417262772 0.4334960 2.254282 0.85225000 0.9520667 0.73810000 -0.21396667 3.001490e-05 3.00149e-05 FALSE TRUE
MSTRG.33236.7 ENSG00000119314 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP3 protein_coding   10.19785 3.1274 19.38935 0.3670383 0.3053166 2.628367 0.4581164 0.009166294 1.212270 0.009166294 0.1102908 5.994847 0.02936667 0.0035000 0.06240000 0.05890000 9.084887e-05 3.00149e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119314 E001 0.1451727 0.0433314839 1.000000e+00   9 112217716 112218434 719 - 0.055 0.001 -5.896
ENSG00000119314 E002 438.6078596 0.0082898409 6.366692e-19 3.590803e-17 9 112218435 112220087 1653 - 2.414 2.838 1.412
ENSG00000119314 E003 121.5845523 0.0054951928 6.304181e-01 7.455977e-01 9 112220088 112220373 286 - 1.949 2.050 0.341
ENSG00000119314 E004 463.4554785 0.0002330384 2.443965e-01 3.793479e-01 9 112220374 112222244 1871 - 2.529 2.626 0.325
ENSG00000119314 E005 39.0839194 0.0006031834 1.446086e-02 3.927130e-02 9 112222245 112222354 110 - 1.434 1.668 0.800
ENSG00000119314 E006 117.8581439 0.0003163025 6.388461e-01 7.524032e-01 9 112222355 112222660 306 - 1.945 2.000 0.183
ENSG00000119314 E007 232.3956952 0.0008345146 2.538193e-01 3.904295e-01 9 112222661 112223983 1323 - 2.241 2.277 0.122
ENSG00000119314 E008 75.7349456 0.0003566028 4.294887e-02 9.645016e-02 9 112224133 112224210 78 - 1.772 1.736 -0.122
ENSG00000119314 E009 118.6962897 0.0003100903 1.658474e-03 6.149192e-03 9 112227411 112227627 217 - 1.969 1.905 -0.216
ENSG00000119314 E010 70.1096767 0.0007006584 2.596844e-03 9.056448e-03 9 112228380 112228472 93 - 1.749 1.645 -0.353
ENSG00000119314 E011 49.0223373 0.0089030025 1.449408e-01 2.547558e-01 9 112231380 112231413 34 - 1.590 1.540 -0.171
ENSG00000119314 E012 82.3276907 0.0056502151 2.241402e-03 7.971218e-03 9 112232099 112232238 140 - 1.821 1.689 -0.449
ENSG00000119314 E013 61.3917860 0.0004060888 5.569009e-06 3.921615e-05 9 112234820 112234897 78 - 1.707 1.478 -0.780
ENSG00000119314 E014 68.5330539 0.0004101224 4.336297e-05 2.479621e-04 9 112250929 112251103 175 - 1.747 1.570 -0.604
ENSG00000119314 E015 53.3341973 0.0033846679 4.751303e-05 2.691586e-04 9 112252678 112252788 111 - 1.648 1.404 -0.834
ENSG00000119314 E016 48.1017653 0.0008726733 1.319413e-05 8.522295e-05 9 112262435 112262504 70 - 1.608 1.346 -0.898
ENSG00000119314 E017 60.2608572 0.0004278815 4.140417e-07 3.722956e-06 9 112262505 112262599 95 - 1.704 1.430 -0.937
ENSG00000119314 E018 72.6680631 0.0003382716 7.231948e-08 7.545689e-07 9 112268049 112268195 147 - 1.783 1.521 -0.889
ENSG00000119314 E019 37.7922007 0.0005264065 8.642986e-04 3.488480e-03 9 112275844 112275909 66 - 1.500 1.298 -0.700
ENSG00000119314 E020 51.1954344 0.0015926483 4.039651e-07 3.639952e-06 9 112275910 112276013 104 - 1.641 1.314 -1.123
ENSG00000119314 E021 18.5564590 0.0020028017 1.076966e-02 3.061505e-02 9 112297832 112297840 9 - 1.211 0.984 -0.820
ENSG00000119314 E022 66.1865829 0.0201817350 1.344860e-03 5.126144e-03 9 112297841 112297916 76 - 1.741 1.490 -0.855
ENSG00000119314 E023 2.0856738 0.0878648181 3.527939e-01 4.970494e-01 9 112330441 112330474 34 - 0.439 0.252 -1.153
ENSG00000119314 E024 2.2282185 0.0075757216 3.718601e-02 8.582402e-02 9 112332784 112333029 246 - 0.480 0.000 -12.036
ENSG00000119314 E025 54.9040111 0.0617488381 2.229848e-02 5.629264e-02 9 112333470 112333664 195 - 1.663 1.395 -0.920