ENSG00000119280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366663 ENSG00000119280 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf198 protein_coding protein_coding 24.17136 33.15098 20.89697 1.011619 0.1160714 -0.6655024 17.696381 19.44019 20.69204 4.177498 0.1796014 0.08998801 0.7517542 0.5803 0.9901667 0.4098667 3.436487e-07 7.542437e-14 FALSE TRUE
ENST00000470540 ENSG00000119280 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf198 protein_coding protein_coding 24.17136 33.15098 20.89697 1.011619 0.1160714 -0.6655024 6.311923 13.64703 0.00000 3.200961 0.0000000 -10.41542821 0.2414875 0.4177 0.0000000 -0.4177000 7.542437e-14 7.542437e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119280 E001 0.1482932 0.0412098906 8.042319e-01   1 230837119 230837119 1 - 0.000 0.100 9.520
ENSG00000119280 E002 302.6694593 0.0032177569 2.645671e-27 3.509904e-25 1 230837120 230837376 257 - 2.131 2.567 1.456
ENSG00000119280 E003 295.6291615 0.0039590916 8.874214e-27 1.123792e-24 1 230837377 230837497 121 - 2.098 2.561 1.544
ENSG00000119280 E004 1297.9520089 0.0024869015 2.667335e-10 4.372781e-09 1 230837498 230838697 1200 - 2.971 3.143 0.570
ENSG00000119280 E005 714.6667894 0.0002384718 2.346551e-13 6.332578e-12 1 230838698 230839468 771 - 2.870 2.809 -0.202
ENSG00000119280 E006 205.5380292 0.0006921687 7.883399e-02 1.576527e-01 1 230839469 230839620 152 - 2.294 2.286 -0.027
ENSG00000119280 E007 330.4294735 0.0001900590 2.548311e-03 8.907357e-03 1 230839621 230839908 288 - 2.511 2.491 -0.066
ENSG00000119280 E008 381.8740784 0.0003051239 7.955758e-10 1.201820e-08 1 230843354 230843670 317 - 2.609 2.532 -0.257
ENSG00000119280 E009 252.0248827 0.0002828265 5.577619e-10 8.667568e-09 1 230843671 230843836 166 - 2.444 2.341 -0.343
ENSG00000119280 E010 109.3023052 0.0003074555 1.079047e-05 7.115038e-05 1 230843837 230843857 21 - 2.088 1.977 -0.372
ENSG00000119280 E011 108.1657325 0.0008017650 6.487627e-07 5.610104e-06 1 230843858 230843896 39 - 2.098 1.959 -0.469
ENSG00000119280 E012 96.4567295 0.0053269773 2.184738e-04 1.042917e-03 1 230855668 230855718 51 - 2.052 1.908 -0.484
ENSG00000119280 E013 0.1472490 0.0424490092 2.868027e-01   1 230855719 230855877 159 - 0.149 0.000 -12.920
ENSG00000119280 E014 0.2214452 0.0396898461 8.023144e-01   1 230855878 230856134 257 - 0.000 0.100 11.489
ENSG00000119280 E015 186.6292993 0.0111930812 2.303559e-04 1.093110e-03 1 230868180 230868390 211 - 2.350 2.186 -0.549
ENSG00000119280 E016 84.5291543 0.0083325956 4.876731e-04 2.113083e-03 1 230868391 230868402 12 - 2.007 1.846 -0.542
ENSG00000119280 E017 99.9140609 0.0130045649 7.624027e-04 3.123187e-03 1 230868403 230868442 40 - 2.087 1.912 -0.587
ENSG00000119280 E018 99.1505395 0.0146506233 4.865426e-04 2.108715e-03 1 230868443 230868811 369 - 2.094 1.901 -0.647
ENSG00000119280 E019 3.3653282 0.0120124570 7.530558e-01 8.391121e-01 1 230868812 230868915 104 - 0.631 0.613 -0.077
ENSG00000119280 E020 0.2214452 0.0396898461 8.023144e-01   1 230868916 230868918 3 - 0.000 0.100 11.489
ENSG00000119280 E021 0.3729606 0.0290017337 6.881052e-01 7.902908e-01 1 230868919 230869047 129 - 0.149 0.100 -0.660
ENSG00000119280 E022 1.1167064 0.0124980894 6.418699e-02 1.336752e-01 1 230869048 230869481 434 - 0.484 0.181 -1.984
ENSG00000119280 E023 0.0000000       1 230869482 230869589 108 -