ENSG00000119203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238112 ENSG00000119203 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF3 protein_coding protein_coding 44.92694 34.19282 62.97493 0.4972833 2.062372 0.8808915 41.72306 32.92767 56.50539 0.3098948 2.214185 0.7789052 0.9321917 0.9633333 0.8969 -0.06643333 0.02351755 0.02229242 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119203 E001 25.739791 0.0311054071 2.676267e-01 4.059468e-01 2 9423651 9423653 3 + 1.473 1.351 -0.423
ENSG00000119203 E002 214.161619 0.0082879966 5.299498e-05 2.967440e-04 2 9423654 9423823 170 + 2.413 2.206 -0.690
ENSG00000119203 E003 2.797051 0.0055355400 9.631191e-02 1.848464e-01 2 9423824 9423883 60 + 0.681 0.409 -1.282
ENSG00000119203 E004 2.807650 0.0054791952 3.749212e-04 1.677041e-03 2 9423884 9424052 169 + 0.770 0.143 -3.645
ENSG00000119203 E005 1.260733 0.0101213724 8.366418e-01 8.978501e-01 2 9424053 9424960 908 + 0.372 0.337 -0.213
ENSG00000119203 E006 207.493447 0.0025156487 8.590251e-12 1.809023e-10 2 9428765 9428828 64 + 2.411 2.170 -0.806
ENSG00000119203 E007 217.632385 0.0026202223 5.799913e-07 5.069325e-06 2 9429923 9430020 98 + 2.409 2.234 -0.583
ENSG00000119203 E008 260.874027 0.0084225889 1.780485e-03 6.537602e-03 2 9430752 9430880 129 + 2.480 2.324 -0.519
ENSG00000119203 E009 343.310867 0.0064639138 2.283450e-04 1.084736e-03 2 9432511 9432688 178 + 2.600 2.442 -0.528
ENSG00000119203 E010 260.367052 0.0007308975 4.805867e-07 4.265035e-06 2 9433871 9433960 90 + 2.469 2.341 -0.427
ENSG00000119203 E011 339.435281 0.0001487100 1.102520e-08 1.348902e-07 2 9436211 9436361 151 + 2.578 2.466 -0.374
ENSG00000119203 E012 430.357130 0.0001492418 9.880224e-05 5.162531e-04 2 9440491 9440666 176 + 2.663 2.595 -0.225
ENSG00000119203 E013 5.046361 0.0052174653 3.424354e-04 1.550066e-03 2 9441730 9441817 88 + 0.948 0.408 -2.333
ENSG00000119203 E014 447.017133 0.0001403331 1.112350e-01 2.073698e-01 2 9441818 9441976 159 + 2.662 2.635 -0.088
ENSG00000119203 E015 473.275066 0.0001173812 5.095067e-01 6.448360e-01 2 9443515 9443661 147 + 2.669 2.681 0.039
ENSG00000119203 E016 450.396779 0.0002020809 2.484599e-01 3.841131e-01 2 9448198 9448350 153 + 2.644 2.664 0.069
ENSG00000119203 E017 344.822550 0.0001438793 5.890975e-04 2.493590e-03 2 9452913 9453021 109 + 2.506 2.573 0.223
ENSG00000119203 E018 288.350769 0.0001472819 1.363264e-12 3.267125e-11 2 9455659 9455757 99 + 2.385 2.535 0.498
ENSG00000119203 E019 215.409071 0.0002232268 3.421689e-08 3.811093e-07 2 9456933 9456976 44 + 2.265 2.401 0.455
ENSG00000119203 E020 239.357722 0.0005117360 2.731234e-06 2.063423e-05 2 9456977 9457027 51 + 2.322 2.439 0.391
ENSG00000119203 E021 361.925467 0.0023027774 5.908679e-05 3.269508e-04 2 9459531 9459618 88 + 2.501 2.619 0.394
ENSG00000119203 E022 353.645155 0.0045567866 3.939128e-03 1.297092e-02 2 9467707 9467776 70 + 2.496 2.605 0.365
ENSG00000119203 E023 4.802431 0.2447818628 9.447089e-01 9.693039e-01 2 9467777 9467975 199 + 0.770 0.737 -0.131
ENSG00000119203 E024 388.204402 0.0062182285 1.696669e-04 8.335812e-04 2 9471343 9471439 97 + 2.510 2.669 0.529
ENSG00000119203 E025 304.885686 0.0052233115 6.030836e-06 4.215488e-05 2 9472916 9473101 186 + 2.392 2.576 0.614