ENSG00000119185

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359712 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding protein_coding 53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 3.444388 3.357204 2.726329 0.5396916 0.3763192 -0.2993097 0.06787083 0.06383333 0.04396667 -0.01986667 2.319870e-01 2.001668e-07 FALSE  
ENST00000464228 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding nonsense_mediated_decay 53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 9.495789 13.608954 8.384401 3.8814609 1.0054596 -0.6981166 0.17244167 0.24710000 0.13490000 -0.11220000 6.844101e-02 2.001668e-07    
ENST00000497031 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding processed_transcript 53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 2.582817 5.512342 1.334055 1.6406518 0.8372823 -2.0386880 0.04439167 0.10023333 0.02096667 -0.07926667 2.865773e-01 2.001668e-07 FALSE  
MSTRG.17920.14 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding   53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 5.573052 2.647615 8.144867 0.1689052 0.1867271 1.6175293 0.10170833 0.05183333 0.13183333 0.08000000 2.001668e-07 2.001668e-07 TRUE  
MSTRG.17920.15 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding   53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 5.646936 7.968593 7.053865 1.0837106 1.5528801 -0.1756765 0.10591250 0.15356667 0.11536667 -0.03820000 6.029844e-01 2.001668e-07 TRUE  
MSTRG.17920.17 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding   53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 5.989111 4.794343 8.524804 0.6061115 0.6570679 0.8290189 0.10945000 0.09236667 0.13800000 0.04563333 9.432382e-02 2.001668e-07 TRUE  
MSTRG.17920.27 ENSG00000119185 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1BP1 protein_coding   53.92564 53.02855 61.92887 8.887399 1.790604 0.2238039 3.354560 3.730190 5.073743 0.7948475 0.4893747 0.4427796 0.05750833 0.07073333 0.08203333 0.01130000 7.628944e-01 2.001668e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119185 E001 5.954877 0.0372533751 7.730383e-01 0.8535050728 2 9403475 9405683 2209 - 0.866 0.807 -0.229
ENSG00000119185 E002 0.000000       2 9405684 9405693 10 -      
ENSG00000119185 E003 13.202374 0.0336233589 5.661064e-01 0.6931200371 2 9405694 9406003 310 - 1.196 1.098 -0.347
ENSG00000119185 E004 5.983823 0.0027236590 1.546160e-01 0.2678916216 2 9406004 9406008 5 - 0.938 0.760 -0.691
ENSG00000119185 E005 6.281543 0.0027365308 4.317829e-02 0.0968723379 2 9406009 9406013 5 - 0.986 0.736 -0.967
ENSG00000119185 E006 8.094967 0.0020905683 1.182419e-02 0.0331114698 2 9406014 9406046 33 - 1.092 0.806 -1.074
ENSG00000119185 E007 2.905240 0.3401096974 8.837521e-02 0.1726378439 2 9406047 9406106 60 - 0.781 0.303 -2.322
ENSG00000119185 E008 2.304491 0.0102438150 2.551530e-04 0.0011966917 2 9406107 9406113 7 - 0.754 0.120 -3.880
ENSG00000119185 E009 18.983125 0.0999004270 5.149353e-02 0.1118034108 2 9406114 9406158 45 - 1.473 1.078 -1.386
ENSG00000119185 E010 11.281563 0.0863378379 1.053871e-01 0.1986891445 2 9406159 9406326 168 - 1.223 0.927 -1.074
ENSG00000119185 E011 1.333774 0.4791668040 3.640421e-02 0.0843505389 2 9406327 9406348 22 - 0.603 0.000 -12.389
ENSG00000119185 E012 1.182259 0.6294565921 8.739787e-02 0.1711929032 2 9406349 9406382 34 - 0.565 0.000 -12.216
ENSG00000119185 E013 13.931798 0.0621369545 9.262698e-03 0.0269404074 2 9406383 9406393 11 - 1.362 0.921 -1.584
ENSG00000119185 E014 13.927532 0.0536507161 5.829687e-03 0.0181623589 2 9406394 9406449 56 - 1.362 0.921 -1.585
ENSG00000119185 E015 13.992052 0.0289723483 3.038115e-04 0.0013948281 2 9406450 9406494 45 - 1.374 0.903 -1.697
ENSG00000119185 E016 17.615291 0.0761310353 1.676070e-01 0.2850761468 2 9406495 9406561 67 - 1.381 1.144 -0.834
ENSG00000119185 E017 7.793070 0.0046189965 2.162336e-03 0.0077276042 2 9406562 9406647 86 - 1.103 0.736 -1.394
ENSG00000119185 E018 5.508743 0.0068568095 3.306575e-03 0.0111671414 2 9406648 9406659 12 - 0.986 0.586 -1.604
ENSG00000119185 E019 7.645439 0.0021586717 8.698944e-01 0.9203094448 2 9406660 9406660 1 - 0.955 0.935 -0.075
ENSG00000119185 E020 8.267858 0.0020052746 8.647909e-01 0.9168557558 2 9406661 9406666 6 - 0.986 0.966 -0.075
ENSG00000119185 E021 189.172520 0.0021202837 3.758036e-04 0.0016805908 2 9406667 9406813 147 - 2.215 2.334 0.398
ENSG00000119185 E022 360.213576 0.0015177740 9.468425e-05 0.0004970529 2 9406814 9406905 92 - 2.505 2.602 0.323
ENSG00000119185 E023 22.792644 0.0008305555 2.191560e-02 0.0555017403 2 9406906 9407029 124 - 1.287 1.451 0.570
ENSG00000119185 E024 35.445976 0.0018685105 2.687723e-01 0.4072535938 2 9407030 9407429 400 - 1.528 1.591 0.216
ENSG00000119185 E025 12.894474 0.0020941731 5.944842e-01 0.7167064300 2 9407430 9407448 19 - 1.177 1.126 -0.182
ENSG00000119185 E026 346.128604 0.0003423501 6.196453e-02 0.1299216614 2 9407449 9407542 94 - 2.527 2.563 0.118
ENSG00000119185 E027 245.298651 0.0002224605 4.249552e-01 0.5679069029 2 9407543 9407571 29 - 2.390 2.406 0.054
ENSG00000119185 E028 215.055484 0.0006346815 6.917794e-01 0.7931790279 2 9407572 9407598 27 - 2.349 2.337 -0.041
ENSG00000119185 E029 2.577680 0.0067772280 2.844674e-01 0.4247069748 2 9408002 9408112 111 - 0.637 0.463 -0.810
ENSG00000119185 E030 291.467468 0.0001678967 2.861893e-01 0.4265930562 2 9408113 9408151 39 - 2.462 2.481 0.066
ENSG00000119185 E031 297.525900 0.0002093398 3.424422e-02 0.0802248653 2 9408152 9408205 54 - 2.458 2.499 0.138
ENSG00000119185 E032 3.807090 0.0041511136 6.020500e-01 0.7230805516 2 9408206 9408404 199 - 0.728 0.652 -0.316
ENSG00000119185 E033 2.433551 0.0061675242 7.339216e-01 0.8250363606 2 9412068 9412268 201 - 0.565 0.508 -0.266
ENSG00000119185 E034 270.481900 0.0002172777 1.039872e-01 0.1965701408 2 9412269 9412296 28 - 2.421 2.454 0.110
ENSG00000119185 E035 219.471680 0.0002302389 9.327154e-02 0.1802363632 2 9412297 9412303 7 - 2.328 2.367 0.128
ENSG00000119185 E036 330.424391 0.0001619640 4.424293e-01 0.5840492496 2 9412304 9412359 56 - 2.536 2.519 -0.057
ENSG00000119185 E037 333.215588 0.0004240454 3.403946e-01 0.4843566667 2 9412360 9412405 46 - 2.541 2.517 -0.083
ENSG00000119185 E038 2.903893 0.1221893695 9.000480e-02 0.1751439561 2 9412406 9412717 312 - 0.755 0.408 -1.588
ENSG00000119185 E039 339.069981 0.0013684369 1.324242e-03 0.0050574262 2 9414178 9414256 79 - 2.582 2.489 -0.308
ENSG00000119185 E040 379.363453 0.0010852144 1.656160e-03 0.0061414529 2 9418626 9418732 107 - 2.627 2.544 -0.276
ENSG00000119185 E041 39.191385 0.0005392459 8.153585e-02 0.1619526777 2 9419990 9420100 111 - 1.663 1.566 -0.332
ENSG00000119185 E042 3.651435 0.0043142946 7.513924e-01 0.8378450358 2 9420101 9420294 194 - 0.699 0.652 -0.200
ENSG00000119185 E043 92.131736 0.0139912533 2.050874e-02 0.0525611246 2 9422479 9422660 182 - 1.886 2.027 0.471
ENSG00000119185 E044 72.453883 0.0089222506 3.018026e-01 0.4436274232 2 9422661 9422801 141 - 1.839 1.893 0.182
ENSG00000119185 E045 83.435744 0.0003322335 2.945615e-02 0.0708889746 2 9422802 9422965 164 - 1.887 1.969 0.276
ENSG00000119185 E046 64.727843 0.0003997265 8.101402e-02 0.1611290338 2 9422966 9423277 312 - 1.781 1.855 0.250
ENSG00000119185 E047 1.249092 0.0390275811 9.384320e-01 0.9653522272 2 9423278 9423372 95 - 0.368 0.355 -0.078
ENSG00000119185 E048 205.603898 0.0032543606 7.668120e-03 0.0229473077 2 9423373 9423543 171 - 2.375 2.266 -0.362