ENSG00000119042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260926 ENSG00000119042 HEK293_OSMI2_2hA HEK293_TMG_2hB SATB2 protein_coding protein_coding 5.39426 4.029343 5.361272 0.225783 0.1920694 0.4111433 1.8323938 1.9279825 0.6038532 0.41381788 0.3273114 -1.658590 0.35374167 0.4773333 0.11726667 -0.36006667 2.275563e-01 8.051245e-08 FALSE TRUE
ENST00000417098 ENSG00000119042 HEK293_OSMI2_2hA HEK293_TMG_2hB SATB2 protein_coding protein_coding 5.39426 4.029343 5.361272 0.225783 0.1920694 0.4111433 2.5477671 1.2285693 3.4629637 0.08433077 0.1056735 1.487493 0.45105417 0.3088000 0.64616667 0.33736667 8.051245e-08 8.051245e-08 FALSE TRUE
ENST00000428695 ENSG00000119042 HEK293_OSMI2_2hA HEK293_TMG_2hB SATB2 protein_coding protein_coding 5.39426 4.029343 5.361272 0.225783 0.1920694 0.4111433 0.2184079 0.0000000 0.6477862 0.00000000 0.2239650 6.039547 0.03882500 0.0000000 0.12126667 0.12126667 2.101749e-05 8.051245e-08 FALSE TRUE
ENST00000457245 ENSG00000119042 HEK293_OSMI2_2hA HEK293_TMG_2hB SATB2 protein_coding protein_coding 5.39426 4.029343 5.361272 0.225783 0.1920694 0.4111433 0.2921852 0.0000000 0.5018556 0.00000000 0.5018556 5.677665 0.04373333 0.0000000 0.08823333 0.08823333 8.777641e-01 8.051245e-08 FALSE TRUE
ENST00000614512 ENSG00000119042 HEK293_OSMI2_2hA HEK293_TMG_2hB SATB2 protein_coding protein_coding 5.39426 4.029343 5.361272 0.225783 0.1920694 0.4111433 0.2844486 0.6934679 0.0000000 0.46990806 0.0000000 -6.136413 0.06889167 0.1707333 0.00000000 -0.17073333 1.459890e-01 8.051245e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000119042 E001 0.0000000       2 199269500 199269504 5 -      
ENSG00000119042 E002 0.2214452 0.0379477975 3.980846e-01   2 199269505 199269507 3 - 0.000 0.146 9.344
ENSG00000119042 E003 344.4372763 0.0058670340 5.124221e-20 3.260895e-18 2 199269508 199271974 2467 - 2.341 2.695 1.179
ENSG00000119042 E004 42.1400174 0.0071303886 7.236327e-01 8.174150e-01 2 199271975 199272149 175 - 1.581 1.682 0.345
ENSG00000119042 E005 66.7284108 0.0004380109 6.011939e-02 1.268065e-01 2 199272150 199272446 297 - 1.823 1.823 0.001
ENSG00000119042 E006 48.0941695 0.0005024453 1.944609e-03 7.054641e-03 2 199272447 199272672 226 - 1.722 1.646 -0.256
ENSG00000119042 E007 27.8293958 0.0063395619 5.015152e-01 6.376676e-01 2 199308760 199308859 100 - 1.442 1.472 0.102
ENSG00000119042 E008 27.6130249 0.0006894940 2.247680e-01 3.561557e-01 2 199308860 199308957 98 - 1.454 1.454 -0.002
ENSG00000119042 E009 38.9242680 0.0005555161 4.139340e-04 1.827896e-03 2 199323803 199323958 156 - 1.645 1.526 -0.406
ENSG00000119042 E010 40.7345701 0.0005601878 3.126744e-03 1.063813e-02 2 199328698 199328910 213 - 1.656 1.575 -0.276
ENSG00000119042 E011 0.3299976 0.0274424043 1.486682e-01   2 199328911 199329035 125 - 0.000 0.254 12.560
ENSG00000119042 E012 0.4783925 0.0222358717 6.979585e-01 7.979997e-01 2 199346866 199348700 1835 - 0.186 0.145 -0.424
ENSG00000119042 E013 70.2988471 0.0004315579 1.713714e-05 1.079315e-04 2 199348701 199349173 473 - 1.892 1.794 -0.332
ENSG00000119042 E014 12.6523749 0.0060374264 2.132373e-02 5.426737e-02 2 199368605 199368609 5 - 1.195 1.039 -0.562
ENSG00000119042 E015 27.7926813 0.0007948418 4.338370e-07 3.884724e-06 2 199368610 199368707 98 - 1.552 1.285 -0.922
ENSG00000119042 E016 0.0000000       2 199368708 199368943 236 -      
ENSG00000119042 E017 27.8318093 0.0059500564 9.241707e-04 3.699788e-03 2 199380364 199380487 124 - 1.518 1.346 -0.595
ENSG00000119042 E018 27.6781357 0.0009400899 4.613574e-02 1.022853e-01 2 199381694 199381820 127 - 1.470 1.416 -0.187
ENSG00000119042 E019 1.1071269 0.2478775996 3.812096e-01 5.255082e-01 2 199395831 199397006 1176 - 0.185 0.421 1.621
ENSG00000119042 E020 2.6957812 0.0057543069 3.623877e-01 5.067859e-01 2 199397530 199397840 311 - 0.457 0.661 0.939
ENSG00000119042 E021 2.2433390 0.0067018917 3.590126e-01 5.033515e-01 2 199419565 199419653 89 - 0.415 0.621 0.990
ENSG00000119042 E022 0.0000000       2 199423686 199423915 230 -      
ENSG00000119042 E023 40.4563804 0.0035576806 2.719770e-01 4.107953e-01 2 199433338 199433514 177 - 1.607 1.619 0.042
ENSG00000119042 E024 34.0773151 0.0108268353 7.719889e-02 1.550016e-01 2 199455869 199456052 184 - 1.568 1.510 -0.195
ENSG00000119042 E025 21.8742761 0.0094245353 7.896385e-03 2.351747e-02 2 199456053 199456096 44 - 1.420 1.267 -0.535
ENSG00000119042 E026 62.0585273 0.0004233659 5.304553e-08 5.687541e-07 2 199457339 199458745 1407 - 1.862 1.698 -0.553
ENSG00000119042 E027 0.0000000       2 199460452 199460532 81 -      
ENSG00000119042 E028 0.0000000       2 199464836 199464920 85 -      
ENSG00000119042 E029 0.0000000       2 199464921 199465167 247 -      
ENSG00000119042 E030 0.0000000       2 199471014 199471266 253 -